4GL9
 
 | | Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain | | 分子名称: | 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Interleukin-6 receptor subunit beta, PHOSPHATE ION, ... | | 著者 | Kershaw, N.J, Murphy, J.M, Laktyushin, A, Nicola, N.A, Babon, J.J. | | 登録日 | 2012-08-14 | | 公開日 | 2013-03-06 | | 最終更新日 | 2018-06-13 | | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | | 主引用文献 | SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition.
Nat.Struct.Mol.Biol., 20, 2013
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6WCZ
 | | CryoEM structure of full-length ZIKV NS5-hSTAT2 complex | | 分子名称: | Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION | | 著者 | Boxiao, W, Stephanie, T, Kang, Z, Maria, T.S, Jian, F, Jiuwei, L, Linfeng, G, Wendan, R, Yanxiang, C, Ethan, C.V, HeaJin, H, Matthew, J.E, Sean, E.O, Adolfo, G.S, Hong, Z, Rong, H, Jikui, S. | | 登録日 | 2020-03-31 | | 公開日 | 2020-07-08 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural basis for STAT2 suppression by flavivirus NS5.
Nat.Struct.Mol.Biol., 27, 2020
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8H36
 | | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a dimeric complex | | 分子名称: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | 登録日 | 2022-10-08 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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7ZNN
 | | Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and full-length rat STAT2 | | 分子名称: | B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ... | | 著者 | Lauer, S, Spahn, C.M.T, Schwefel, D. | | 登録日 | 2022-04-21 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-03-15 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor.
Embo J., 42, 2023
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8H37
 | | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a tetrameric complex | | 分子名称: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | | 著者 | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | 登録日 | 2022-10-08 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (7.52 Å) | | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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1WQU
 | | Solution structure of the human FES SH2 domain | | 分子名称: | Proto-oncogene tyrosine-protein kinase FES/FPS | | 著者 | Scott, A, Pantoja-Uceda, D, Koshiba, S, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Tanaka, A, Sugano, S, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2004-10-02 | | 公開日 | 2005-06-14 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes
J.Biomol.NMR, 31, 2005
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2YSX
 | | Solution structure of the human SHIP SH2 domain | | 分子名称: | Signaling inositol polyphosphate phosphatase SHIP II | | 著者 | Kasai, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-04-04 | | 公開日 | 2008-04-08 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the human SHIP SH2 domain
To be Published
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2CR4
 | | Solution structure of the SH2 domain of human SH3BP2 protein | | 分子名称: | SH3 domain-binding protein 2 | | 著者 | Hatta, R, Tomizawa, T, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2005-05-20 | | 公開日 | 2005-11-20 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the SH2 domain of human SH3BP2 protein
To be Published
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2L6K
 | | Solution Structure of a Nonphosphorylated Peptide Recognizing Domain | | 分子名称: | Tensin-like C1 domain-containing phosphatase | | 著者 | Dai, K, Liao, S, Zhang, J, Zhang, X, Tu, X. | | 登録日 | 2010-11-22 | | 公開日 | 2011-10-12 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of Tensin2 SH2 domain and its phosphotyrosine-independent interaction with DLC-1
Plos One, 6, 2011
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1X0N
 | | NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor | | 分子名称: | 4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONIC ACID, Growth factor receptor-bound protein 2 | | 著者 | Ogura, K, Shiga, T, Yuzawa, S, Yokochi, M, Burke, T.R, Inagaki, F. | | 登録日 | 2005-03-24 | | 公開日 | 2005-04-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor
To be Published
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2RMX
 | | Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A | | 分子名称: | NKG2-A/NKG2-B type II integral membrane protein, Tyrosine-protein phosphatase non-receptor type 6 | | 著者 | Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-11-30 | | 公開日 | 2008-12-02 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for the recognition of the two NKG2A immunoreceptor tyrosine-based inhibitory motifs (ITIMs) by the C-terminal SH2 domain of protein tyrosine phosphatase SHP-1
To be Published
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6AMW
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2LNW
 | | Identification and structural basis for a novel interaction between Vav2 and Arap3 | | 分子名称: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3, Guanine nucleotide exchange factor VAV2 | | 著者 | Wu, B, Zhang, J, Wu, J, Shi, Y. | | 登録日 | 2012-01-05 | | 公開日 | 2012-11-21 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Identification and structural basis for a novel interaction between Vav2 and Arap3.
J.Struct.Biol., 180, 2012
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2LQW
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1FHS
 | | THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY DOMAIN-2 OF THE GROWTH FACTOR RECEPTOR BOUND PROTEIN-2, NMR, 18 STRUCTURES | | 分子名称: | GROWTH FACTOR RECEPTOR BOUND PROTEIN-2 | | 著者 | Senior, M.M, Frederick, A.F, Black, S, Perkins, L.M, Wilson, O, Snow, M.E, Wang, Y.-S. | | 登録日 | 1997-06-12 | | 公開日 | 1998-06-17 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The three-dimensional solution structure of the Src homology domain-2 of the growth factor receptor-bound protein-2.
J.Biomol.NMR, 11, 1998
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2LCT
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2RSY
 | | Solution structure of the SH2 domain of Csk in complex with a phosphopeptide from Cbp | | 分子名称: | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Tyrosine-protein kinase CSK | | 著者 | Tanaka, H, Akagi, K, Oneyama, C, Tanaka, M, Sasaki, Y, Kanou, T, Lee, Y, Yokogawa, D, Debenecker, M, Nakagawa, A, Okada, M, Ikegami, T. | | 登録日 | 2012-09-10 | | 公開日 | 2013-04-10 | | 最終更新日 | 2019-12-25 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains.
J.Biol.Chem., 288, 2013
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2LNX
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6R5G
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2RVF
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1BFJ
 | | SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, MINIMIZED AVERAGE STRUCTURE | | 分子名称: | P85 ALPHA | | 著者 | Siegal, G, Davis, B, Kristensen, S.M, Sankar, A, Linacre, J, Stein, R.C, Panayotou, G, Waterfield, M.D, Driscoll, P.C. | | 登録日 | 1997-11-18 | | 公開日 | 1998-02-25 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase.
J.Mol.Biol., 276, 1998
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1PIC
 | | PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, NMR, MINIMIZED MEAN STRUCTURE | | 分子名称: | BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR, PHOSPHATIDYLINOSITOL 3-KINASE | | 著者 | Breeze, A.L, Kara, B.V, Barratt, D.G, Anderson, M, Smith, J.C, Luke, R.W, Best, J.R, Cartlidge, S.A. | | 登録日 | 1997-06-23 | | 公開日 | 1997-09-17 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase.
EMBO J., 15, 1996
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1AOU
 | | NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, 22 STRUCTURES | | 分子名称: | FYN PROTEIN-TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE | | 著者 | Mulhern, T.D, Shaw, G.L, Morton, C.J, Day, A.J, Campbell, I.D. | | 登録日 | 1997-07-10 | | 公開日 | 1998-01-14 | | 最終更新日 | 2021-11-03 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.
Structure, 5, 1997
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1MW4
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1BFI
 | | SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, 30 STRUCTURES | | 分子名称: | P85 ALPHA | | 著者 | Siegal, G, Davis, B, Kristensen, S.M, Sankar, A, Linacre, J, Stein, R.C, Panayotou, G, Waterfield, M.D, Driscoll, P.C. | | 登録日 | 1997-11-18 | | 公開日 | 1998-02-25 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase.
J.Mol.Biol., 276, 1998
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