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3UF4
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Crystal structure of a SH3 and SH2 domains of FYN protein (Proto-concogene Tyrosine-protein kinase Fyn) from Mus musculus at 1.98 A resolution
分子名称: CHLORIDE ION, GLYCEROL, SODIUM ION, ...
著者Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL)
登録日2011-10-31
公開日2011-12-07
最終更新日2023-02-01
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Crystal structure of a SH3 and SH2 domains of FYN protein (Proto-concogene Tyrosine-protein kinase Fyn) from Mus musculus at 1.98 A resolution
To be published
3VS2
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BU of 3vs2 by Molmil
Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
分子名称: 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ...
著者Kuratani, M, Tomabechi, Y, Niwa, H, Parker, J.L, Handa, N, Yokoyama, S.
登録日2012-04-21
公開日2013-05-01
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.609 Å)
主引用文献A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo
Sci Transl Med, 5, 2013
2ABL
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BU of 2abl by Molmil
SH3-SH2 DOMAIN FRAGMENT OF HUMAN BCR-ABL TYROSINE KINASE
分子名称: ABL TYROSINE KINASE
著者Nam, H.-J, Frederick, C.A.
登録日1996-11-17
公開日1997-09-04
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Intramolecular interactions of the regulatory domains of the Bcr-Abl kinase reveal a novel control mechanism.
Structure, 4, 1996
2C0T
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BU of 2c0t by Molmil
Src family kinase Hck with bound inhibitor A-641359
分子名称: CALCIUM ION, N-(4-{4-AMINO-1-[1-(TETRAHYDRO-2H-PYRAN-4-YL)PIPERIDIN-4-YL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE, TYROSINE-PROTEIN KINASE HCK
著者Borhani, D.W, Burchat, A, Calderwood, D.J, Hirst, G.C, Li, B, Loew, A.
登録日2005-09-07
公開日2006-09-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Discovery of A-770041, a Src-Family Selective Orally Active Lck Inhibitor that Prevents Organ Allograft Rejection.
Bioorg.Med.Chem.Lett., 16, 2006
1GRI
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BU of 1gri by Molmil
GRB2
分子名称: GROWTH FACTOR BOUND PROTEIN 2
著者Maignan, S, Arnoux, B, Ducruix, A.
登録日1995-02-28
公開日1996-03-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal structure of the mammalian Grb2 adaptor.
Science, 268, 1995
1G83
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BU of 1g83 by Molmil
CRYSTAL STRUCTURE OF FYN SH3-SH2
分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN
著者Arold, S.T, Ulmer, T.S, Mulhern, T.D, Werner, J.M, Ladbury, J.E, Campbell, I.D, Noble, M.E.M.
登録日2000-11-16
公開日2001-05-30
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases.
J.Biol.Chem., 276, 2001
1YVL
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BU of 1yvl by Molmil
Structure of Unphosphorylated STAT1
分子名称: 5-residue peptide, GOLD ION, Signal transducer and activator of transcription 1-alpha/beta
著者Mao, X, Ren, Z, Parker, G.N, Sondermann, H, Pastorello, M.A, Wang, W, McMurray, J.S, Demeler, B, Darnell Jr, J.E, Chen, X.
登録日2005-02-16
公開日2005-03-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural bases of unphosphorylated STAT1 association and receptor binding.
Mol.Cell, 17, 2005
2C0O
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BU of 2c0o by Molmil
Src family kinase Hck with bound inhibitor A-770041
分子名称: CALCIUM ION, N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEXYL]-4-AMINO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE, TYROSINE-PROTEIN KINASE HCK
著者Borhani, D.W, Burchat, A, Calderwood, D.J, Hirst, G.C, Li, B, Loew, A.
登録日2005-09-06
公開日2006-09-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Discovery of A-770041, a Src-Family Selective Orally Active Lck Inhibitor that Prevents Organ Allograft Rejection.
Bioorg.Med.Chem.Lett., 16, 2006
2C0I
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BU of 2c0i by Molmil
Src family kinase Hck with bound inhibitor A-420983
分子名称: CALCIUM ION, N-(4-{4-AMINO-1-[4-(4-METHYLPIPERAZIN-1-YL)-TRANS-CYCLOHEXYL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE, TYROSINE-PROTEIN KINASE HCK
著者Borhani, D.W, Burchat, A, Calderwood, D.J, Hirst, G.C, Li, B, Loew, A.
登録日2005-09-03
公開日2006-09-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of A-770041, a Src-Family Selective Orally Active Lck Inhibitor that Prevents Organ Allograft Rejection.
Bioorg.Med.Chem.Lett., 16, 2006
1FMK
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BU of 1fmk by Molmil
CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC
分子名称: TYROSINE-PROTEIN KINASE SRC
著者Xu, W, Harrison, S.C, Eck, M.J.
登録日1997-01-24
公開日1997-08-20
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Three-dimensional structure of the tyrosine kinase c-Src.
Nature, 385, 1997
2C9W
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BU of 2c9w by Molmil
CRYSTAL STRUCTURE OF SOCS-2 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 1.9A RESOLUTION
分子名称: NICKEL (II) ION, SULFATE ION, SUPPRESSOR OF CYTOKINE SIGNALING 2, ...
著者Debreczeni, J.E, Bullock, A, Amos, A, Savitsky, P, Barr, A, Burgess, N, Sundstrom, M, Weigelt, J, Arrowsmith, C, Edwards, A, Knapp, S.
登録日2005-12-14
公開日2006-02-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.
Proc. Natl. Acad. Sci. U.S.A., 103, 2006
2B3O
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BU of 2b3o by Molmil
Crystal structure of human tyrosine phosphatase SHP-1
分子名称: Tyrosine-protein phosphatase, non-receptor type 6
著者Yang, J, Liu, L, He, D, Song, X, Liang, X, Zhao, Z.J, Zhou, G.W.
登録日2005-09-20
公開日2005-10-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of human protein-tyrosine phosphatase SHP-1.
J.Biol.Chem., 278, 2003
2K79
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BU of 2k79 by Molmil
Solution Structure of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase
分子名称: SH2 domain of Tyrosine-protein kinase ITK/TSK, SH3 domain of Tyrosine-protein kinase ITK/TSK
著者Andreotti, A.H, Severin, A.J, Fulton, D.B.
登録日2008-08-08
公開日2009-03-10
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain.
J.Mol.Biol., 387, 2009
2K7A
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BU of 2k7a by Molmil
Ensemble Structures of the binary complex between the SH3 and SH2 domain of interleukin-2 tyrosine kinase.
分子名称: SH2 domain of Tyrosine-protein kinase ITK/TSK, SH3 domain of Tyrosine-protein kinase ITK/TSK
著者Andreotti, A.H, Severin, A.J, Fulton, D.B.
登録日2008-08-08
公開日2009-03-10
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain.
J.Mol.Biol., 387, 2009
2LQW
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BU of 2lqw by Molmil
Solution structure of phosphorylated CRKL
分子名称: Crk-like protein
著者Jankowski, W, Saleh, T, Kalodimos, C.
登録日2012-03-16
公開日2012-05-16
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII.
Nat.Chem.Biol., 8, 2012
2IZV
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BU of 2izv by Molmil
CRYSTAL STRUCTURE OF SOCS-4 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 2.55A RESOLUTION
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, SODIUM ION, ...
著者Debreczeni, J.E, Bullock, A, Papagrigoriou, E, Turnbull, A, Pike, A.C.W, Gorrec, F, von Delft, F, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, Knapp, S.
登録日2006-07-26
公開日2006-08-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation.
Structure, 15, 2007
2LQN
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BU of 2lqn by Molmil
Solution structure of CRKL
分子名称: Crk-like protein
著者Jankowski, W, Saleh, T, Kalodimos, C.
登録日2012-03-09
公開日2012-05-16
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII.
Nat.Chem.Biol., 8, 2012
1OPL
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BU of 1opl by Molmil
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
分子名称: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, MYRISTIC ACID, proto-oncogene tyrosine-protein kinase
著者Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J.
登録日2003-03-06
公開日2003-04-08
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.42 Å)
主引用文献Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
1TCE
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BU of 1tce by Molmil
SOLUTION NMR STRUCTURE OF THE SHC SH2 DOMAIN COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDE FROM THE T-CELL RECEPTOR, MINIMIZED AVERAGE STRUCTURE
分子名称: PHOSPHOPEPTIDE OF THE ZETA CHAIN OF T CELL RECEPTOR, SHC
著者Zhou, M.-M, Meadows, R.P, Logan, T.M, Yoon, H.S, Wade, W.R, Ravichandran, K.S, Burakoff, S.J, Feisk, S.W.
登録日1996-03-27
公開日1997-05-15
最終更新日2022-03-02
実験手法SOLUTION NMR
主引用文献Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor.
Proc.Natl.Acad.Sci.USA, 92, 1995
1QCF
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BU of 1qcf by Molmil
CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR
分子名称: 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, Tyrosine-protein kinase HCK
著者Schindler, T, Sicheri, F, Pico, A, Gazit, A, Levitzki, A, Kuriyan, J.
登録日1999-05-04
公開日1999-06-08
最終更新日2022-12-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor.
Mol.Cell, 3, 1999
1RQQ
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BU of 1rqq by Molmil
Crystal Structure of the Insulin Receptor Kinase in Complex with the SH2 Domain of APS
分子名称: BISUBSTRATE INHIBITOR, Insulin receptor, MANGANESE (II) ION, ...
著者Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R.
登録日2003-12-06
公開日2003-12-30
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.
Mol.Cell, 12, 2003
5SXD
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BU of 5sxd by Molmil
Crystal Structure of PI3Kalpha in complex with fragment 22
分子名称: 2-methoxybenzoic acid, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Gabelli, S.B, Vogelstein, B, Miller, M.S, Amzel, L.M.
登録日2016-08-09
公開日2017-02-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design.
Bioorg. Med. Chem., 25, 2017
5SW8
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Crystal structure of PI3Kalpha in complex with fragments 7 and 11
分子名称: 2-CHLOROBENZENESULFONAMIDE, 2H-indazol-5-amine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Gabelli, S.B, Vogelstein, B, Miller, M.S, Amzel, L.M.
登録日2016-08-08
公開日2017-02-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design.
Bioorg. Med. Chem., 25, 2017
5SWP
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Crystal Structure of PI3Kalpha in complex with fragments 6 and 24
分子名称: 2-methylcyclohexane-1,3-dione, CHLORIDE ION, Phosphatidylinositol 3-kinase regulatory subunit alpha, ...
著者Gabelli, S.B, Vogelstein, B, Miller, M.S, Amzel, L.M.
登録日2016-08-08
公開日2017-02-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.41 Å)
主引用文献Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design.
Bioorg. Med. Chem., 25, 2017
5SXB
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Crystal Structure of PI3Kalpha in complex with fragment 23
分子名称: ISATOIC ANHYDRIDE, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Gabelli, S.B, Vogelstein, B, Miller, M.S, Amzel, L.M.
登録日2016-08-09
公開日2017-02-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design.
Bioorg. Med. Chem., 25, 2017

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