6C7Y
Crystal structure of inhibitory protein SOCS1 in complex with JAK1 kinase domain
Summary for 6C7Y
Entry DOI | 10.2210/pdb6c7y/pdb |
Related | 6C5X |
Descriptor | Tyrosine-protein kinase JAK1, Suppressor of cytokine signaling 1, ADENOSINE-5'-DIPHOSPHATE, ... (7 entities in total) |
Functional Keywords | kinase, kinase inhibitor, signaling protein, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 46822.74 |
Authors | Liau, N.P.D.,Laktyushin, A.,Lucet, I.S.,Murphy, J.M.,Yao, S.,Callaghan, K.,Nicola, N.A.,Kershaw, N.J.,Babon, J.J. (deposition date: 2018-01-23, release date: 2018-05-02, Last modification date: 2023-11-15) |
Primary citation | Liau, N.P.D.,Laktyushin, A.,Lucet, I.S.,Murphy, J.M.,Yao, S.,Whitlock, E.,Callaghan, K.,Nicola, N.A.,Kershaw, N.J.,Babon, J.J. The molecular basis of JAK/STAT inhibition by SOCS1. Nat Commun, 9:1558-1558, 2018 Cited by PubMed: 29674694DOI: 10.1038/s41467-018-04013-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.499 Å) |
Structure validation
Download full validation report