6C7Y

Crystal structure of inhibitory protein SOCS1 in complex with JAK1 kinase domain

Summary for 6C7Y

• Entry DOI: 10.2210/pdb6c7y/pdb
• Related: 6C5X
• Descriptor: Tyrosine-protein kinase JAK1, Suppressor of cytokine signaling 1, ADENOSINE-5'-DIPHOSPHATE, ... (7 entities in total)
• Functional Keywords: kinase, kinase inhibitor, signaling protein, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 46822.74

Authors

Liau, N.P.D.,Laktyushin, A.,Lucet, I.S.,Murphy, J.M.,Yao, S.,Callaghan, K.,Nicola, N.A.,Kershaw, N.J.,Babon, J.J. (deposition date: 2018-01-23, release date: 2018-05-02, Last modification date: 2023-11-15)

• Primary citation: Liau, N.P.D.,Laktyushin, A.,Lucet, I.S.,Murphy, J.M.,Yao, S.,Whitlock, E.,Callaghan, K.,Nicola, N.A.,Kershaw, N.J.,Babon, J.J.; The molecular basis of JAK/STAT inhibition by SOCS1.; Nat Commun, 9:1558-1558, 2018; PubMed: 29674694; DOI: 10.1038/s41467-018-04013-1

Experimental method

X-RAY DIFFRACTION (2.499 Å)