6C7Y
Crystal structure of inhibitory protein SOCS1 in complex with JAK1 kinase domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase JAK1 | polymer | 286 | 32938.7 | 1 | UniProt (P23458) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 1, JAK-1 |
| 2 | B | Suppressor of cytokine signaling 1 | polymer | 117 | 13163.0 | 1 | UniProt (B6RCQ2) Pfam (PF00017) In PDB | Gallus gallus (Chicken) | |
| 3 | A | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 6 | B | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 7 | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A: 869 - 1153 (UniProt: P23458)
| PDB | External Database | Details |
|---|---|---|
| Ala 868 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46101.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 721.1 | |
| All* | Total formula weight | 46822.7 |
