6BMR
Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP244
Summary for 6BMR
Entry DOI | 10.2210/pdb6bmr/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, 4-[(2-chlorophenyl)methyl]-1-(2-hydroxy-3-methoxyphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | shp2, ptpn11, protein tyrosine phosphatase, phosphatase, allosteric inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q06124 |
Total number of polymer chains | 2 |
Total formula weight | 122387.65 |
Authors | |
Primary citation | Fodor, M.,Price, E.,Wang, P.,Lu, H.,Argintaru, A.,Chen, Z.,Glick, M.,Hao, H.X.,Kato, M.,Koenig, R.,LaRochelle, J.R.,Liu, G.,McNeill, E.,Majumdar, D.,Nishiguchi, G.A.,Perez, L.B.,Paris, G.,Quinn, C.M.,Ramsey, T.,Sendzik, M.,Shultz, M.D.,Williams, S.L.,Stams, T.,Blacklow, S.C.,Acker, M.G.,LaMarche, M.J. Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem. Biol., 13:647-656, 2018 Cited by PubMed: 29304282DOI: 10.1021/acschembio.7b00980 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.205 Å) |
Structure validation
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