6CRF

Crystal Structure of Shp2 E76K GOF Mutant in the Open Conformation

Summary for 6CRF

Entry DOI	10.2210/pdb6crf/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 11, GLYCEROL (3 entities in total)
Functional Keywords	shp2, ptpn11, protein tyrosine phosphatase, e76k, gain of function mutant, open conformation, phosphatase, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	120702.24
Authors	Stams, T.,Fodor, M. (deposition date: 2018-03-17, release date: 2018-11-07, Last modification date: 2023-10-04)
Primary citation	LaRochelle, J.R.,Fodor, M.,Vemulapalli, V.,Mohseni, M.,Wang, P.,Stams, T.,LaMarche, M.J.,Chopra, R.,Acker, M.G.,Blacklow, S.C. Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nat Commun, 9:4508-4508, 2018 Cited by PubMed: 30375388 DOI: 10.1038/s41467-018-06823-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.62 Å)

Structure validation