6CRF
Crystal Structure of Shp2 E76K GOF Mutant in the Open Conformation
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 526 | 60305.1 | 2 | UniProt (Q06124) Pfam (PF00017) Pfam (PF00102) In PDB | Homo sapiens (Human) | Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,Shp2,SH-PTP3 |
2 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
3 | water | water | 18.0 | 208 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 525 (UniProt: Q06124)
PDB | External Database | Details |
---|---|---|
Gly 0 | - | expression tag |
Lys 76 | Glu 76 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 120610.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 92.1 | |
All* | Total formula weight | 120702.2 |