6BMY

Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitors SHP099 and SHP844

Summary for 6BMY

• Entry DOI: 10.2210/pdb6bmy/pdb
• Related: 6BMR 6BMU 6BMV 6BMW 6BMX
• Descriptor: Tyrosine-protein phosphatase non-receptor type 11, 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, 1-(3-chloro-4-{[1-(2-hydroxy-3-methoxyphenyl)-5-oxo[1,2,4]triazolo[4,3-a]quinazolin-4(5H)-yl]methyl}benzene-1-carbonyl)-L-proline, ... (6 entities in total)
• Functional Keywords: shp2, ptpn11, protein tyrosine phosphatase, phosphatase, allosteric inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q06124
• Total number of polymer chains: 2
• Total formula weight: 123086.63

Authors

Stams, T.,Fodor, M. (deposition date: 2017-11-15, release date: 2018-01-17, Last modification date: 2023-10-04)

• Primary citation: Fodor, M.,Price, E.,Wang, P.,Lu, H.,Argintaru, A.,Chen, Z.,Glick, M.,Hao, H.X.,Kato, M.,Koenig, R.,LaRochelle, J.R.,Liu, G.,McNeill, E.,Majumdar, D.,Nishiguchi, G.A.,Perez, L.B.,Paris, G.,Quinn, C.M.,Ramsey, T.,Sendzik, M.,Shultz, M.D.,Williams, S.L.,Stams, T.,Blacklow, S.C.,Acker, M.G.,LaMarche, M.J.; Dual Allosteric Inhibition of SHP2 Phosphatase.; ACS Chem. Biol., 13:647-656, 2018; PubMed: 29304282; DOI: 10.1021/acschembio.7b00980

Experimental method

X-RAY DIFFRACTION (2.09 Å)