6BMY
Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitors SHP099 and SHP844
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 526 | 60335.0 | 2 | UniProt (Q06124) Pfam (PF00017) Pfam (PF00102) | Homo sapiens (Human) | Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,Shp2,SH-PTP3 |
| 2 | C, F (A, B) | 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine | non-polymer | 352.3 | 2 | Chemie (5OD) | |||
| 3 | D, G (A, B) | 1-(3-chloro-4-{[1-(2-hydroxy-3-methoxyphenyl)-5-oxo[1,2,4]triazolo[4,3-a]quinazolin-4(5H)-yl]methyl}benzene-1-carbonyl)-L-proline | non-polymer | 574.0 | 2 | Chemie (DYV) | |||
| 4 | E, H, I, J (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 5 | K, L (B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | M, N (A, B) | water | water | 18.0 | 476 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 525 (UniProt: Q06124)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 120670.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2416.6 | |
| All* | Total formula weight | 123086.6 |
