2AA9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2aa9 by Molmil](/molmil-images/mine/2aa9) | EPSP synthase liganded with shikimate | 分子名称: | (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, 3-phosphoshikimate 1-carboxyvinyltransferase, FORMIC ACID | 著者 | Priestman, M.A, Healy, M.L, Funke, T, Becker, A, Schonbrunn, E. | 登録日 | 2005-07-13 | 公開日 | 2006-02-14 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Molecular basis for the glyphosate-insensitivity of the reaction of 5-enolpyruvylshikimate 3-phosphate synthase with shikimate. Febs Lett., 579, 2005
|
|
1QK1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1qk1 by Molmil](/molmil-images/mine/1qk1) | CRYSTAL STRUCTURE OF HUMAN UBIQUITOUS MITOCHONDRIAL CREATINE KINASE | 分子名称: | CREATINE KINASE, UBIQUITOUS MITOCHONDRIAL, PHOSPHATE ION | 著者 | Eder, M, Schlattner, U, Fritz-Wolf, K, Wallimann, T, Kabsch, W. | 登録日 | 1999-07-08 | 公開日 | 2000-04-11 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal Structure of Human Ubiquitous Mitochondrial Creatine Kinase Proteins: Struct.,Funct., Genet., 39, 2000
|
|
1QLV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1qlv by Molmil](/molmil-images/mine/1qlv) | |
2QGN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2qgn by Molmil](/molmil-images/mine/2qgn) | Crystal structure of tRNA isopentenylpyrophosphate transferase (BH2366) from Bacillus halodurans, Northeast Structural Genomics Consortium target BhR41. | 分子名称: | SULFATE ION, tRNA delta(2)-isopentenylpyrophosphate transferase | 著者 | Forouhar, F, Neely, H, Abashidze, M, Seetharaman, J, Shastry, R, Janjua, H, Cunningham, K, Ma, L.-C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2007-06-29 | 公開日 | 2007-07-17 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of tRNA isopentenylpyrophosphate transferase (BH2366) from Bacillus halodurans. To be Published
|
|
2AAZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2aaz by Molmil](/molmil-images/mine/2aaz) | Cryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate | 分子名称: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase | 著者 | Finer-Moore, J.S, Anderson, A.C, O'Neil, R.H, Costi, M.P, Ferrari, S, Krucinski, J, Stroud, R.M. | 登録日 | 2005-07-14 | 公開日 | 2005-12-06 | 最終更新日 | 2018-02-14 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. Acta Crystallogr.,Sect.D, 61, 2005
|
|
2QH1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2qh1 by Molmil](/molmil-images/mine/2qh1) | Structure of TA289, a CBS-rubredoxin-like protein, in its Fe+2-bound state | 分子名称: | FE (II) ION, Hypothetical protein Ta0289 | 著者 | Singer, A.U, Proudfoot, M, Brown, G, Xu, L, Savchenko, A, Yakunin, A.F, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2007-06-29 | 公開日 | 2008-02-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Biochemical and structural characterization of a novel family of cystathionine beta-synthase domain proteins fused to a Zn ribbon-like domain. J.Mol.Biol., 375, 2008
|
|
1QOV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1qov by Molmil](/molmil-images/mine/1qov) | PHOTOSYNTHETIC REACTION CENTER MUTANT WITH ALA M260 REPLACED WITH TRP (CHAIN M, A260W) | 分子名称: | BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, CARDIOLIPIN, ... | 著者 | McAuley, K.E, Fyfe, P.K, Ridge, J.P, Isaacs, N.W, Cogdell, R.J, Jones, M.R. | 登録日 | 1999-11-17 | 公開日 | 1999-12-13 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Details of an Interaction between Cardiolipin and an Integral Membrane Protein Proc.Natl.Acad.Sci.USA, 96, 1999
|
|
2QIA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2qia by Molmil](/molmil-images/mine/2qia) | |
2QIR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2qir by Molmil](/molmil-images/mine/2qir) | Crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A and kanamycin | 分子名称: | (1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL 2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE, Aminoglycoside 6-N-acetyltransferase type Ib11, COENZYME A | 著者 | Maurice, F, Broutin, I, Podglajen, I, Benas, P, Collatz, E, Dardel, F. | 登録日 | 2007-07-05 | 公開日 | 2008-04-08 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance. Embo Rep., 9, 2008
|
|
4FOG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4fog by Molmil](/molmil-images/mine/4fog) | Crystal Structure of Mtb ThyA in Complex with 5-Fluoro-dUMP and 5-methyltetrahydrofolic acid | 分子名称: | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, Thymidylate synthase | 著者 | Reddy, M.C.M, Bruning, J.B, Harshbarger, W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2012-06-20 | 公開日 | 2013-08-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: Insights into the selectivity and mode of inhibition To be Published
|
|
4FOX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4fox by Molmil](/molmil-images/mine/4fox) | Crystal Structure of Mtb ThyA in complex with dUMP and Raltitrexed | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, Thymidylate synthase | 著者 | Reddy, M.C.M, Bruning, J.B, Sacchettini, J.C, Harshbarger, W, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2012-06-21 | 公開日 | 2013-08-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: Insights into the selectivity and mode of inhibition To be Published
|
|
2QFT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2qft by Molmil](/molmil-images/mine/2qft) | |
3PH7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ph7 by Molmil](/molmil-images/mine/3ph7) | Crystal structure of Plasmodium vivax putative polyprenyl pyrophosphate synthase in complex with geranylgeranyl diphosphate | 分子名称: | Farnesyl pyrophosphate synthase, GERANYLGERANYL DIPHOSPHATE | 著者 | Wernimont, A.K, Dunford, J, Lew, J, Zhao, Y, Kozieradzki, I, Cossar, D, Schapiro, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Hui, R, Artz, J.D, Structural Genomics Consortium (SGC) | 登録日 | 2010-11-03 | 公開日 | 2010-11-17 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites. J.Biol.Chem., 286, 2011
|
|
2AAY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2aay by Molmil](/molmil-images/mine/2aay) | EPSP synthase liganded with shikimate and glyphosate | 分子名称: | (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, 3-phosphoshikimate 1-carboxyvinyltransferase, FORMIC ACID, ... | 著者 | Priestman, M.A, Healy, M.L, Funke, T, Becker, A. | 登録日 | 2005-07-14 | 公開日 | 2006-02-14 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Molecular basis for the glyphosate-insensitivity of the reaction of 5-enolpyruvylshikimate 3-phosphate synthase with shikimate. Febs Lett., 579, 2005
|
|
2AE6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ae6 by Molmil](/molmil-images/mine/2ae6) | Crystal Structure of Acetyltransferase of GNAT family from Enterococcus faecalis V583 | 分子名称: | ETHANOL, GLYCEROL, MAGNESIUM ION, ... | 著者 | Kim, Y, Hatzos, C, Moy, S, Collart, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2005-07-21 | 公開日 | 2005-09-06 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Crystal Structure of Acetyltransferase of GNAT family from Enterococcus faecalis V583 To be Published
|
|
4G22
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4g22 by Molmil](/molmil-images/mine/4g22) | |
3QJ7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3qj7 by Molmil](/molmil-images/mine/3qj7) | Crystal Structure of the Mycobacterium tuberculosis Thymidylate synthase (ThyA) bound to dUMP | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, SPERMINE, Thymidylate synthase | 著者 | Reddy, M.C.M, Bruning, J.B, Harshbarger, W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2011-01-28 | 公開日 | 2011-06-15 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.504 Å) | 主引用文献 | Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: insights into the selectivity and mode of inhibition To be Published
|
|
2ABQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2abq by Molmil](/molmil-images/mine/2abq) | |
1YHK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yhk by Molmil](/molmil-images/mine/1yhk) | Trypanosoma cruzi farnesyl diphosphate synthase | 分子名称: | SULFATE ION, farnesyl pyrophosphate synthase | 著者 | Gabelli, S.B, McLellan, J.S, Montalvetti, A, Oldfield, E, Docampo, R, Amzel, L.M. | 登録日 | 2005-01-09 | 公開日 | 2005-12-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design. Proteins, 62, 2005
|
|
1Y7R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1y7r by Molmil](/molmil-images/mine/1y7r) | 1.7 A Crystal Structure of Protein of Unknown Function SA2161 from Meticillin-Resistant Staphylococcus aureus, Probable Acetyltransferase | 分子名称: | PHOSPHATE ION, hypothetical protein SA2161 | 著者 | Qiu, Y, Zhang, R, Collart, F, Holzle, D, Joachimiak, A, Kossiakoff, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2004-12-09 | 公開日 | 2005-01-25 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | 1.7A Crystal Structure of Hypothetical Protein SA2161 from Meticillin-Resistant Staphylococcus aureus To be Published
|
|
3QGT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3qgt by Molmil](/molmil-images/mine/3qgt) | Crystal structure of Wild-type PfDHFR-TS COMPLEXED WITH NADPH, dUMP AND PYRIMETHAMINE | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, Bifunctional dihydrofolate reductase-thymidylate synthase, ... | 著者 | Chitnumsub, P, Yuthavong, Y. | 登録日 | 2011-01-24 | 公開日 | 2011-06-29 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Trypanosomal dihydrofolate reductase reveals natural antifolate resistance Acs Chem.Biol., 6, 2011
|
|
2OPM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2opm by Molmil](/molmil-images/mine/2opm) | Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461 | 分子名称: | 3-FLUORO-1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)PYRIDINIUM, Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10)], MAGNESIUM ION, ... | 著者 | Cao, R, Gao, Y.G, Robinson, H, Goddard, A. | 登録日 | 2007-01-29 | 公開日 | 2007-12-11 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J.Am.Chem.Soc., 131, 2009
|
|
2OZH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ozh by Molmil](/molmil-images/mine/2ozh) | |
1ZPR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1zpr by Molmil](/molmil-images/mine/1zpr) | E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | 分子名称: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | 著者 | Sage, C.R, Stout, T.J, Rutenber, E.E, Stroud, R.M. | 登録日 | 1996-10-15 | 公開日 | 1997-07-07 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q. Biochemistry, 35, 1996
|
|
4G2O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4g2o by Molmil](/molmil-images/mine/4g2o) | |