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1ZPR

E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)

Summary for 1ZPR
Entry DOI10.2210/pdb1zpr/pdb
DescriptorTHYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total)
Functional Keywordstransferase, active site mutant, reaction intermediate
Biological sourceEscherichia coli
Cellular locationCytoplasm: P0A884
Total number of polymer chains2
Total formula weight62688.66
Authors
Sage, C.R.,Stout, T.J.,Rutenber, E.E.,Stroud, R.M. (deposition date: 1996-10-15, release date: 1997-07-07, Last modification date: 2021-11-03)
Primary citationSage, C.R.,Rutenber, E.E.,Stout, T.J.,Stroud, R.M.
An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q.
Biochemistry, 35:16270-16281, 1996
Cited by
PubMed: 8973201
DOI: 10.1021/bi961269r
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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