2OPM

Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461

Summary for 2OPM

Entry DOI	10.2210/pdb2opm/pdb
Related	2OPN
Descriptor	Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10)], PHOSPHATE ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	protein-bisphosphonate complex, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	43578.75
Authors	Cao, R.,Gao, Y.G.,Robinson, H.,Goddard, A. (deposition date: 2007-01-29, release date: 2007-12-11, Last modification date: 2023-08-30)
Primary citation	Zhang, Y.,Cao, R.,Yin, F.,Hudock, M.P.,Guo, R.T.,Krysiak, K.,Mukherjee, S.,Gao, Y.G.,Robinson, H.,Song, Y.,No, J.H.,Bergan, K.,Leon, A.,Cass, L.,Goddard, A.,Chang, T.K.,Lin, F.Y.,Van Beek, E.,Papapoulos, S.,Wang, A.H.,Kubo, T.,Ochi, M.,Mukkamala, D.,Oldfield, E. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J.Am.Chem.Soc., 131:5153-5162, 2009 Cited by PubMed: 19309137 DOI: 10.1021/ja808285e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation