2OPM
Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10)] | polymer | 374 | 43013.8 | 1 | UniProt (P14324) Pfam (PF00348) In PDB | Homo sapiens (human) | |
| 2 | A | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | A | 3-FLUORO-1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)PYRIDINIUM | non-polymer | 302.1 | 1 | Chemie (NI9) | |||
| 5 | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A: 15 - 367 (UniProt: P14324)
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | cloning artifact |
| Ser -5 | - | cloning artifact |
| Ser -4 | - | cloning artifact |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
| His 2 | - | expression tag |
| Ser 3 | - | cloning artifact |
| Ser 4 | - | cloning artifact |
| Gly 5 | - | cloning artifact |
| Arg 6 | - | cloning artifact |
| Glu 7 | - | cloning artifact |
| Asn 8 | - | cloning artifact |
| Leu 9 | - | cloning artifact |
| Tyr 10 | - | cloning artifact |
| Phe 11 | - | cloning artifact |
| Gln 12 | - | cloning artifact |
| Gly 13 | - | cloning artifact |
| His 14 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 43013.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 565.0 | |
| All* | Total formula weight | 43578.8 |
