3QJ7

Crystal Structure of the Mycobacterium tuberculosis Thymidylate synthase (ThyA) bound to dUMP

Summary for 3QJ7

• Entry DOI: 10.2210/pdb3qj7/pdb
• Descriptor: Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, SPERMINE, ... (4 entities in total)
• Functional Keywords: thymidilate synthase, structural genomics, tb structural genomics consortium, tbsgc, transferase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 4
• Total formula weight: 121322.70

Authors

Reddy, M.C.M.,Bruning, J.B.,Harshbarger, W.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2011-01-28, release date: 2011-06-15, Last modification date: 2023-09-13)

• Primary citation: Reddy, M.C.M.,Bruning, J.B.,Harshbarger, W.,Sacchettini, J.C.; Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: insights into the selectivity and mode of inhibition; To be Published,

Experimental method

X-RAY DIFFRACTION (2.504 Å)