2AAZ
Cryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate
Summary for 2AAZ
Entry DOI | 10.2210/pdb2aaz/pdb |
Related | 2A9W |
Descriptor | Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total) |
Functional Keywords | methyl transferase, nucleotide biosynthesis, transferase |
Biological source | Filobasidiella neoformans |
Total number of polymer chains | 16 |
Total formula weight | 583342.30 |
Authors | Finer-Moore, J.S.,Anderson, A.C.,O'Neil, R.H.,Costi, M.P.,Ferrari, S.,Krucinski, J.,Stroud, R.M. (deposition date: 2005-07-14, release date: 2005-12-06, Last modification date: 2018-02-14) |
Primary citation | Finer-Moore, J.S.,Anderson, A.C.,O'Neil, R.H.,Costi, M.P.,Ferrari, S.,Krucinski, J.,Stroud, R.M. The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. Acta Crystallogr.,Sect.D, 61:1320-1334, 2005 Cited by PubMed: 16204883DOI: 10.1107/S0907444905022638 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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