2AAZ

Cryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate

Summary for 2AAZ

• Entry DOI: 10.2210/pdb2aaz/pdb
• Related: 2A9W
• Descriptor: Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total)
• Functional Keywords: methyl transferase, nucleotide biosynthesis, transferase
• Biological source: Filobasidiella neoformans
• Total number of polymer chains: 16
• Total formula weight: 583342.30

Authors

Finer-Moore, J.S.,Anderson, A.C.,O'Neil, R.H.,Costi, M.P.,Ferrari, S.,Krucinski, J.,Stroud, R.M. (deposition date: 2005-07-14, release date: 2005-12-06, Last modification date: 2018-02-14)

• Primary citation: Finer-Moore, J.S.,Anderson, A.C.,O'Neil, R.H.,Costi, M.P.,Ferrari, S.,Krucinski, J.,Stroud, R.M.; The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition.; Acta Crystallogr.,Sect.D, 61:1320-1334, 2005; PubMed: 16204883; DOI: 10.1107/S0907444905022638

Experimental method

X-RAY DIFFRACTION (2.08 Å)