2AAZ
Cryptococcus neoformans thymidylate synthase complexed with substrate and an antifolate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| A | 0032259 | biological_process | methylation |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| B | 0032259 | biological_process | methylation |
| C | 0004799 | molecular_function | thymidylate synthase activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005829 | cellular_component | cytosol |
| C | 0006231 | biological_process | dTMP biosynthetic process |
| C | 0006235 | biological_process | dTTP biosynthetic process |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0009165 | biological_process | nucleotide biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| C | 0032259 | biological_process | methylation |
| D | 0004799 | molecular_function | thymidylate synthase activity |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005829 | cellular_component | cytosol |
| D | 0006231 | biological_process | dTMP biosynthetic process |
| D | 0006235 | biological_process | dTTP biosynthetic process |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0009165 | biological_process | nucleotide biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| D | 0032259 | biological_process | methylation |
| E | 0004799 | molecular_function | thymidylate synthase activity |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005829 | cellular_component | cytosol |
| E | 0006231 | biological_process | dTMP biosynthetic process |
| E | 0006235 | biological_process | dTTP biosynthetic process |
| E | 0008168 | molecular_function | methyltransferase activity |
| E | 0009165 | biological_process | nucleotide biosynthetic process |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| E | 0032259 | biological_process | methylation |
| F | 0004799 | molecular_function | thymidylate synthase activity |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005829 | cellular_component | cytosol |
| F | 0006231 | biological_process | dTMP biosynthetic process |
| F | 0006235 | biological_process | dTTP biosynthetic process |
| F | 0008168 | molecular_function | methyltransferase activity |
| F | 0009165 | biological_process | nucleotide biosynthetic process |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| F | 0032259 | biological_process | methylation |
| G | 0004799 | molecular_function | thymidylate synthase activity |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005829 | cellular_component | cytosol |
| G | 0006231 | biological_process | dTMP biosynthetic process |
| G | 0006235 | biological_process | dTTP biosynthetic process |
| G | 0008168 | molecular_function | methyltransferase activity |
| G | 0009165 | biological_process | nucleotide biosynthetic process |
| G | 0016740 | molecular_function | transferase activity |
| G | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| G | 0032259 | biological_process | methylation |
| H | 0004799 | molecular_function | thymidylate synthase activity |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005829 | cellular_component | cytosol |
| H | 0006231 | biological_process | dTMP biosynthetic process |
| H | 0006235 | biological_process | dTTP biosynthetic process |
| H | 0008168 | molecular_function | methyltransferase activity |
| H | 0009165 | biological_process | nucleotide biosynthetic process |
| H | 0016740 | molecular_function | transferase activity |
| H | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| H | 0032259 | biological_process | methylation |
| I | 0004799 | molecular_function | thymidylate synthase activity |
| I | 0005739 | cellular_component | mitochondrion |
| I | 0005829 | cellular_component | cytosol |
| I | 0006231 | biological_process | dTMP biosynthetic process |
| I | 0006235 | biological_process | dTTP biosynthetic process |
| I | 0008168 | molecular_function | methyltransferase activity |
| I | 0009165 | biological_process | nucleotide biosynthetic process |
| I | 0016740 | molecular_function | transferase activity |
| I | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| I | 0032259 | biological_process | methylation |
| J | 0004799 | molecular_function | thymidylate synthase activity |
| J | 0005739 | cellular_component | mitochondrion |
| J | 0005829 | cellular_component | cytosol |
| J | 0006231 | biological_process | dTMP biosynthetic process |
| J | 0006235 | biological_process | dTTP biosynthetic process |
| J | 0008168 | molecular_function | methyltransferase activity |
| J | 0009165 | biological_process | nucleotide biosynthetic process |
| J | 0016740 | molecular_function | transferase activity |
| J | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| J | 0032259 | biological_process | methylation |
| K | 0004799 | molecular_function | thymidylate synthase activity |
| K | 0005739 | cellular_component | mitochondrion |
| K | 0005829 | cellular_component | cytosol |
| K | 0006231 | biological_process | dTMP biosynthetic process |
| K | 0006235 | biological_process | dTTP biosynthetic process |
| K | 0008168 | molecular_function | methyltransferase activity |
| K | 0009165 | biological_process | nucleotide biosynthetic process |
| K | 0016740 | molecular_function | transferase activity |
| K | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| K | 0032259 | biological_process | methylation |
| L | 0004799 | molecular_function | thymidylate synthase activity |
| L | 0005739 | cellular_component | mitochondrion |
| L | 0005829 | cellular_component | cytosol |
| L | 0006231 | biological_process | dTMP biosynthetic process |
| L | 0006235 | biological_process | dTTP biosynthetic process |
| L | 0008168 | molecular_function | methyltransferase activity |
| L | 0009165 | biological_process | nucleotide biosynthetic process |
| L | 0016740 | molecular_function | transferase activity |
| L | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| L | 0032259 | biological_process | methylation |
| M | 0004799 | molecular_function | thymidylate synthase activity |
| M | 0005739 | cellular_component | mitochondrion |
| M | 0005829 | cellular_component | cytosol |
| M | 0006231 | biological_process | dTMP biosynthetic process |
| M | 0006235 | biological_process | dTTP biosynthetic process |
| M | 0008168 | molecular_function | methyltransferase activity |
| M | 0009165 | biological_process | nucleotide biosynthetic process |
| M | 0016740 | molecular_function | transferase activity |
| M | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| M | 0032259 | biological_process | methylation |
| N | 0004799 | molecular_function | thymidylate synthase activity |
| N | 0005739 | cellular_component | mitochondrion |
| N | 0005829 | cellular_component | cytosol |
| N | 0006231 | biological_process | dTMP biosynthetic process |
| N | 0006235 | biological_process | dTTP biosynthetic process |
| N | 0008168 | molecular_function | methyltransferase activity |
| N | 0009165 | biological_process | nucleotide biosynthetic process |
| N | 0016740 | molecular_function | transferase activity |
| N | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| N | 0032259 | biological_process | methylation |
| O | 0004799 | molecular_function | thymidylate synthase activity |
| O | 0005739 | cellular_component | mitochondrion |
| O | 0005829 | cellular_component | cytosol |
| O | 0006231 | biological_process | dTMP biosynthetic process |
| O | 0006235 | biological_process | dTTP biosynthetic process |
| O | 0008168 | molecular_function | methyltransferase activity |
| O | 0009165 | biological_process | nucleotide biosynthetic process |
| O | 0016740 | molecular_function | transferase activity |
| O | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| O | 0032259 | biological_process | methylation |
| P | 0004799 | molecular_function | thymidylate synthase activity |
| P | 0005739 | cellular_component | mitochondrion |
| P | 0005829 | cellular_component | cytosol |
| P | 0006231 | biological_process | dTMP biosynthetic process |
| P | 0006235 | biological_process | dTTP biosynthetic process |
| P | 0008168 | molecular_function | methyltransferase activity |
| P | 0009165 | biological_process | nucleotide biosynthetic process |
| P | 0016740 | molecular_function | transferase activity |
| P | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| P | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE UMP A 350 |
| Chain | Residue |
| A | ARG40 |
| A | HIS257 |
| A | TYR259 |
| A | HOH523 |
| A | HOH555 |
| A | CB32351 |
| B | ARG167 |
| B | ARG168 |
| A | CYS187 |
| A | HIS188 |
| A | GLN215 |
| A | ARG216 |
| A | SER217 |
| A | ASP219 |
| A | GLY223 |
| A | ASN227 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE CB3 A 2351 |
| Chain | Residue |
| A | PHE72 |
| A | GLU79 |
| A | ILE100 |
| A | TRP101 |
| A | ASN104 |
| A | ASP219 |
| A | LEU222 |
| A | GLY223 |
| A | PHE226 |
| A | ASN227 |
| A | TYR259 |
| A | MET315 |
| A | SER316 |
| A | UMP350 |
| A | HOH571 |
| A | HOH574 |
| A | HOH657 |
| A | HOH776 |
| A | HOH876 |
| A | HOH979 |
| A | HOH1400 |
| A | HOH1598 |
| H | ARG70 |
| H | LYS310 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE UMP B 400 |
| Chain | Residue |
| A | ARG167 |
| A | ARG168 |
| B | ARG40 |
| B | TYR127 |
| B | CYS187 |
| B | HIS188 |
| B | GLN215 |
| B | ARG216 |
| B | SER217 |
| B | ASP219 |
| B | ASN227 |
| B | HIS257 |
| B | TYR259 |
| B | HOH603 |
| B | HOH729 |
| B | CB32401 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE CB3 B 2401 |
| Chain | Residue |
| B | PHE72 |
| B | GLU79 |
| B | ILE100 |
| B | TRP101 |
| B | ASN104 |
| B | ASP219 |
| B | LEU222 |
| B | GLY223 |
| B | PHE226 |
| B | ASN227 |
| B | TYR259 |
| B | MET315 |
| B | SER316 |
| B | UMP400 |
| B | HOH545 |
| B | HOH632 |
| B | HOH681 |
| B | HOH993 |
| B | HOH994 |
| B | HOH1079 |
| B | HOH1381 |
| G | ARG70 |
| G | LYS310 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE UMP C 450 |
| Chain | Residue |
| C | ARG40 |
| C | CYS187 |
| C | HIS188 |
| C | GLN215 |
| C | ARG216 |
| C | SER217 |
| C | ASP219 |
| C | GLY223 |
| C | ASN227 |
| C | HIS257 |
| C | TYR259 |
| C | HOH525 |
| C | HOH783 |
| C | CB32451 |
| D | ARG167 |
| D | ARG168 |
| site_id | AC6 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE CB3 C 2451 |
| Chain | Residue |
| C | ASN104 |
| C | ASP219 |
| C | LEU222 |
| C | GLY223 |
| C | PHE226 |
| C | ASN227 |
| C | TYR259 |
| C | MET315 |
| C | SER316 |
| C | UMP450 |
| C | HOH538 |
| C | HOH824 |
| C | HOH967 |
| C | HOH968 |
| C | HOH1001 |
| C | HOH1374 |
| C | HOH1435 |
| C | HOH1437 |
| F | ARG70 |
| F | LYS310 |
| C | PHE72 |
| C | GLU79 |
| C | ILE100 |
| C | TRP101 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE UMP D 500 |
| Chain | Residue |
| C | ARG167 |
| C | ARG168 |
| D | ARG40 |
| D | TYR127 |
| D | CYS187 |
| D | HIS188 |
| D | GLN215 |
| D | ARG216 |
| D | SER217 |
| D | ASP219 |
| D | ASN227 |
| D | HIS257 |
| D | TYR259 |
| D | HOH521 |
| D | HOH915 |
| D | CB32501 |
| site_id | AC8 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE CB3 D 2501 |
| Chain | Residue |
| D | PHE72 |
| D | GLU79 |
| D | ILE100 |
| D | TRP101 |
| D | ASN104 |
| D | ASP219 |
| D | LEU222 |
| D | GLY223 |
| D | PHE226 |
| D | ASN227 |
| D | TYR259 |
| D | MET315 |
| D | SER316 |
| D | UMP500 |
| D | HOH520 |
| D | HOH695 |
| D | HOH752 |
| D | HOH771 |
| D | HOH965 |
| D | HOH992 |
| D | HOH1088 |
| D | HOH1375 |
| E | ARG70 |
| E | LYS310 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE UMP E 550 |
| Chain | Residue |
| E | ARG40 |
| E | TYR127 |
| E | CYS187 |
| E | HIS188 |
| E | GLN215 |
| E | ARG216 |
| E | SER217 |
| E | ASP219 |
| E | GLY223 |
| E | ASN227 |
| E | HIS257 |
| E | TYR259 |
| E | HOH514 |
| E | HOH610 |
| E | CB32551 |
| F | ARG167 |
| F | ARG168 |
| site_id | BC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE CB3 E 2551 |
| Chain | Residue |
| D | ARG70 |
| D | LYS310 |
| D | HOH1502 |
| E | PHE72 |
| E | GLU79 |
| E | ILE100 |
| E | TRP101 |
| E | ASN104 |
| E | ASP219 |
| E | LEU222 |
| E | GLY223 |
| E | PHE226 |
| E | ASN227 |
| E | TYR259 |
| E | MET315 |
| E | SER316 |
| E | UMP550 |
| E | HOH565 |
| E | HOH677 |
| E | HOH802 |
| E | HOH1095 |
| E | HOH1233 |
| E | HOH1294 |
| E | HOH1296 |
| site_id | BC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE UMP F 600 |
| Chain | Residue |
| E | ARG167 |
| E | ARG168 |
| F | ARG40 |
| F | TYR127 |
| F | CYS187 |
| F | HIS188 |
| F | GLN215 |
| F | ARG216 |
| F | SER217 |
| F | ASP219 |
| F | ASN227 |
| F | HIS257 |
| F | TYR259 |
| F | HOH622 |
| F | HOH1055 |
| F | CB32601 |
| site_id | BC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE CB3 F 2601 |
| Chain | Residue |
| C | ARG70 |
| C | LYS310 |
| F | PHE72 |
| F | GLU79 |
| F | ILE100 |
| F | TRP101 |
| F | ASN104 |
| F | ASP219 |
| F | LEU222 |
| F | GLY223 |
| F | PHE226 |
| F | ASN227 |
| F | TYR259 |
| F | MET315 |
| F | SER316 |
| F | UMP600 |
| F | HOH759 |
| F | HOH792 |
| F | HOH1041 |
| F | HOH1043 |
| F | HOH1317 |
| F | HOH1377 |
| F | HOH1498 |
| F | HOH1516 |
| site_id | BC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE UMP G 650 |
| Chain | Residue |
| G | ARG40 |
| G | CYS187 |
| G | HIS188 |
| G | GLN215 |
| G | ARG216 |
| G | SER217 |
| G | ASP219 |
| G | ASN227 |
| G | HIS257 |
| G | TYR259 |
| G | HOH423 |
| G | HOH1150 |
| G | CB32651 |
| H | ARG167 |
| H | ARG168 |
| site_id | BC5 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE CB3 G 2651 |
| Chain | Residue |
| B | ARG70 |
| B | LYS310 |
| G | PHE72 |
| G | GLU79 |
| G | ILE100 |
| G | TRP101 |
| G | ASN104 |
| G | ASP219 |
| G | LEU222 |
| G | GLY223 |
| G | PHE226 |
| G | ASN227 |
| G | TYR259 |
| G | MET315 |
| G | SER316 |
| G | HOH451 |
| G | HOH452 |
| G | HOH499 |
| G | HOH502 |
| G | UMP650 |
| G | HOH1151 |
| G | HOH1342 |
| G | HOH1343 |
| site_id | BC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE UMP H 700 |
| Chain | Residue |
| G | ARG167 |
| G | ARG168 |
| H | ARG40 |
| H | CYS187 |
| H | HIS188 |
| H | GLN215 |
| H | ARG216 |
| H | SER217 |
| H | ASP219 |
| H | ASN227 |
| H | HIS257 |
| H | TYR259 |
| H | HOH477 |
| H | HOH1044 |
| H | CB32701 |
| site_id | BC7 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE CB3 H 2701 |
| Chain | Residue |
| A | ARG70 |
| A | LYS310 |
| H | PHE72 |
| H | GLU79 |
| H | ILE100 |
| H | TRP101 |
| H | ASN104 |
| H | LEU184 |
| H | ASP219 |
| H | LEU222 |
| H | GLY223 |
| H | PHE226 |
| H | ASN227 |
| H | TYR259 |
| H | MET315 |
| H | SER316 |
| H | HOH409 |
| H | HOH479 |
| H | UMP700 |
| H | HOH1236 |
| H | HOH1367 |
| H | HOH1371 |
| H | HOH1372 |
| H | HOH1376 |
| H | HOH1439 |
| site_id | BC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE UMP I 350 |
| Chain | Residue |
| I | ARG40 |
| I | TYR127 |
| I | LEU184 |
| I | CYS187 |
| I | HIS188 |
| I | GLN215 |
| I | ARG216 |
| I | SER217 |
| I | ASP219 |
| I | ASN227 |
| I | HIS257 |
| I | TYR259 |
| J | ARG167 |
| J | ARG168 |
| site_id | BC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE UMP J 400 |
| Chain | Residue |
| I | ARG167 |
| I | ARG168 |
| J | ARG40 |
| J | TYR127 |
| J | CYS187 |
| J | HIS188 |
| J | GLN215 |
| J | ARG216 |
| J | SER217 |
| J | ASP219 |
| J | GLY223 |
| J | ASN227 |
| J | HIS257 |
| J | TYR259 |
| site_id | CC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE UMP K 450 |
| Chain | Residue |
| K | ARG40 |
| K | TYR127 |
| K | CYS187 |
| K | HIS188 |
| K | GLN215 |
| K | ARG216 |
| K | SER217 |
| K | CYS218 |
| K | ASP219 |
| K | ASN227 |
| K | HIS257 |
| K | TYR259 |
| L | ARG167 |
| L | ARG168 |
| site_id | CC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE UMP L 500 |
| Chain | Residue |
| K | ARG167 |
| K | ARG168 |
| L | ARG40 |
| L | TYR127 |
| L | CYS187 |
| L | HIS188 |
| L | GLN215 |
| L | ARG216 |
| L | SER217 |
| L | CYS218 |
| L | ASP219 |
| L | ASN227 |
| L | HIS257 |
| L | TYR259 |
| site_id | CC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE UMP M 550 |
| Chain | Residue |
| M | ARG40 |
| M | TYR127 |
| M | CYS187 |
| M | HIS188 |
| M | GLN215 |
| M | ARG216 |
| M | SER217 |
| M | CYS218 |
| M | ASP219 |
| M | ASN227 |
| M | HIS257 |
| M | TYR259 |
| N | ARG167 |
| N | ARG168 |
| site_id | CC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE UMP N 600 |
| Chain | Residue |
| M | ARG167 |
| M | ARG168 |
| N | ARG40 |
| N | PHE109 |
| N | LEU110 |
| N | GLU111 |
| N | LYS112 |
| N | VAL113 |
| N | GLY114 |
| N | LEU115 |
| N | TYR127 |
| N | CYS187 |
| N | HIS188 |
| N | GLN215 |
| N | ARG216 |
| N | SER217 |
| N | CYS218 |
| N | ASP219 |
| N | ASN227 |
| N | HIS257 |
| N | TYR259 |
| site_id | CC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE UMP O 650 |
| Chain | Residue |
| O | ARG40 |
| O | TYR127 |
| O | CYS187 |
| O | HIS188 |
| O | GLN215 |
| O | ARG216 |
| O | SER217 |
| O | ASP219 |
| O | ASN227 |
| O | HIS257 |
| O | TYR259 |
| P | ARG167 |
| P | ARG168 |
| site_id | CC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE UMP P 700 |
| Chain | Residue |
| O | ARG167 |
| O | ARG168 |
| P | ARG40 |
| P | TYR127 |
| P | CYS187 |
| P | HIS188 |
| P | GLN215 |
| P | ARG216 |
| P | SER217 |
| P | CYS218 |
| P | ASP219 |
| P | ASN227 |
| P | HIS257 |
| P | TYR259 |
Functional Information from PROSITE/UniProt
| site_id | PS00091 |
| Number of Residues | 29 |
| Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriIlsaWNpkdlplma.....LpPCHmfcQFfV |
| Chain | Residue | Details |
| A | ARG167-VAL195 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P0A884 |
| Chain | Residue | Details |
| A | CYS187 | |
| J | CYS187 | |
| K | CYS187 | |
| L | CYS187 | |
| M | CYS187 | |
| N | CYS187 | |
| O | CYS187 | |
| P | CYS187 | |
| B | CYS187 | |
| C | CYS187 | |
| D | CYS187 | |
| E | CYS187 | |
| F | CYS187 | |
| G | CYS187 | |
| H | CYS187 | |
| I | CYS187 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 64 |
| Details | BINDING: in other chain => ECO:0000250|UniProtKB:P0A884 |
| Chain | Residue | Details |
| A | ARG40 | |
| C | ARG216 | |
| C | ASN227 | |
| C | HIS257 | |
| D | ARG40 | |
| D | ARG216 | |
| D | ASN227 | |
| D | HIS257 | |
| E | ARG40 | |
| E | ARG216 | |
| E | ASN227 | |
| A | ARG216 | |
| E | HIS257 | |
| F | ARG40 | |
| F | ARG216 | |
| F | ASN227 | |
| F | HIS257 | |
| G | ARG40 | |
| G | ARG216 | |
| G | ASN227 | |
| G | HIS257 | |
| H | ARG40 | |
| A | ASN227 | |
| H | ARG216 | |
| H | ASN227 | |
| H | HIS257 | |
| I | ARG40 | |
| I | ARG216 | |
| I | ASN227 | |
| I | HIS257 | |
| J | ARG40 | |
| J | ARG216 | |
| J | ASN227 | |
| A | HIS257 | |
| J | HIS257 | |
| K | ARG40 | |
| K | ARG216 | |
| K | ASN227 | |
| K | HIS257 | |
| L | ARG40 | |
| L | ARG216 | |
| L | ASN227 | |
| L | HIS257 | |
| M | ARG40 | |
| B | ARG40 | |
| M | ARG216 | |
| M | ASN227 | |
| M | HIS257 | |
| N | ARG40 | |
| N | ARG216 | |
| N | ASN227 | |
| N | HIS257 | |
| O | ARG40 | |
| O | ARG216 | |
| O | ASN227 | |
| B | ARG216 | |
| O | HIS257 | |
| P | ARG40 | |
| P | ARG216 | |
| P | ASN227 | |
| P | HIS257 | |
| B | ASN227 | |
| B | HIS257 | |
| C | ARG40 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0A884 |
| Chain | Residue | Details |
| A | ARG167 | |
| E | ASP219 | |
| F | ARG167 | |
| F | ASP219 | |
| G | ARG167 | |
| G | ASP219 | |
| H | ARG167 | |
| H | ASP219 | |
| I | ARG167 | |
| I | ASP219 | |
| J | ARG167 | |
| A | ASP219 | |
| J | ASP219 | |
| K | ARG167 | |
| K | ASP219 | |
| L | ARG167 | |
| L | ASP219 | |
| M | ARG167 | |
| M | ASP219 | |
| N | ARG167 | |
| N | ASP219 | |
| O | ARG167 | |
| B | ARG167 | |
| O | ASP219 | |
| P | ARG167 | |
| P | ASP219 | |
| B | ASP219 | |
| C | ARG167 | |
| C | ASP219 | |
| D | ARG167 | |
| D | ASP219 | |
| E | ARG167 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| A | CYS187 | |
| A | HIS257 | |
| A | GLU79 | |
| A | ASP219 | |
| A | ASP255 | |
| A | SER217 |
| site_id | CSA10 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| J | CYS187 | |
| J | HIS257 | |
| J | GLU79 | |
| J | ASP219 | |
| J | ASP255 | |
| J | SER217 |
| site_id | CSA11 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| K | CYS187 | |
| K | HIS257 | |
| K | GLU79 | |
| K | ASP219 | |
| K | ASP255 | |
| K | SER217 |
| site_id | CSA12 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| L | CYS187 | |
| L | HIS257 | |
| L | GLU79 | |
| L | ASP219 | |
| L | ASP255 | |
| L | SER217 |
| site_id | CSA13 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| M | CYS187 | |
| M | HIS257 | |
| M | GLU79 | |
| M | ASP219 | |
| M | ASP255 | |
| M | SER217 |
| site_id | CSA14 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| N | CYS187 | |
| N | HIS257 | |
| N | GLU79 | |
| N | ASP219 | |
| N | ASP255 | |
| N | SER217 |
| site_id | CSA15 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| O | CYS187 | |
| O | HIS257 | |
| O | GLU79 | |
| O | ASP219 | |
| O | ASP255 | |
| O | SER217 |
| site_id | CSA16 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| P | CYS187 | |
| P | HIS257 | |
| P | GLU79 | |
| P | ASP219 | |
| P | ASP255 | |
| P | SER217 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| B | CYS187 | |
| B | HIS257 | |
| B | GLU79 | |
| B | ASP219 | |
| B | ASP255 | |
| B | SER217 |
| site_id | CSA3 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| C | CYS187 | |
| C | HIS257 | |
| C | GLU79 | |
| C | ASP219 | |
| C | ASP255 | |
| C | SER217 |
| site_id | CSA4 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| D | CYS187 | |
| D | HIS257 | |
| D | GLU79 | |
| D | ASP219 | |
| D | ASP255 | |
| D | SER217 |
| site_id | CSA5 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| E | CYS187 | |
| E | HIS257 | |
| E | GLU79 | |
| E | ASP219 | |
| E | ASP255 | |
| E | SER217 |
| site_id | CSA6 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| F | CYS187 | |
| F | HIS257 | |
| F | GLU79 | |
| F | ASP219 | |
| F | ASP255 | |
| F | SER217 |
| site_id | CSA7 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| G | CYS187 | |
| G | HIS257 | |
| G | GLU79 | |
| G | ASP219 | |
| G | ASP255 | |
| G | SER217 |
| site_id | CSA8 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| H | CYS187 | |
| H | HIS257 | |
| H | GLU79 | |
| H | ASP219 | |
| H | ASP255 | |
| H | SER217 |
| site_id | CSA9 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1lcb |
| Chain | Residue | Details |
| I | CYS187 | |
| I | HIS257 | |
| I | GLU79 | |
| I | ASP219 | |
| I | ASP255 | |
| I | SER217 |
