7NO0
 
 | | Structure of the mature RSV CA lattice: T=1 CA icosahedron | | 分子名称: | Capsid protein p27, alternate cleaved 1 | | 著者 | Obr, M, Ricana, C.L, Nikulin, N, Feathers, J.-P.R, Klanschnig, M, Thader, A, Johnson, M.C, Vogt, V.M, Schur, F.K.M, Dick, R.A. | | 登録日 | 2021-02-25 | | 公開日 | 2021-04-21 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer.
Nat Commun, 12, 2021
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8RGH
 | | Structure of dynein-2 intermediate chain DYNC2I1 (WDR60) in complex with the dynein-2 heavy chain DYNC2H1. | | 分子名称: | Cytoplasmic dynein 2 intermediate chain 1, Cytoplasmic dynein 2 intermediate chain 2, Cytoplasmic dynein 2 light intermediate chain 1, ... | | 著者 | Mukhopadhyay, A.G, Toropova, K, Daly, L, Wells, J, Vuolo, L, Seda, M, Jenkins, D, Stephens, D.J, Roberts, A.J. | | 登録日 | 2023-12-13 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structure and tethering mechanism of dynein-2 intermediate chains in intraflagellar transport.
Embo J., 43, 2024
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7NO9
 | | Structure of the mature RSV CA lattice: Group I, pentamer-pentamer interface, class 1'1 | | 分子名称: | Capsid protein p27, alternate cleaved 1 | | 著者 | Obr, M, Ricana, C.L, Nikulin, N, Feathers, J.-P.R, Klanschnig, M, Thader, A, Johnson, M.C, Vogt, V.M, Schur, F.K.M, Dick, R.A. | | 登録日 | 2021-02-25 | | 公開日 | 2021-04-21 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (7.6 Å) | | 主引用文献 | Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer.
Nat Commun, 12, 2021
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8IUE
 | | RNA polymerase III pre-initiation complex melting complex 1 | | 分子名称: | DNA (74-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | | 著者 | Hou, H, Jin, Q, Ren, Y, Wang, Q, Xu, Y. | | 登録日 | 2023-03-24 | | 公開日 | 2023-05-24 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structure of the SNAPc-bound RNA polymerase III preinitiation complex.
Cell Res., 33, 2023
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6P2R
 | | Structure of S. cerevisiae protein O-mannosyltransferase Pmt1-Pmt2 complex bound to the sugar donor | | 分子名称: | (3R)-3,31-dimethyl-7,11,15,19,23,27-hexamethylidenedotriacont-31-en-1-yl dihydrogen phosphate, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Bai, L, Li, H. | | 登録日 | 2019-05-21 | | 公開日 | 2019-07-10 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structure of the eukaryotic protein O-mannosyltransferase Pmt1-Pmt2 complex.
Nat.Struct.Mol.Biol., 26, 2019
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6WKR
 | | PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome | | 分子名称: | DNA (314-MER), Histone H2A type 1, Histone H2B 1.1, ... | | 著者 | Kasinath, V, Nogales, E, Beck, C, Sauer, P, Poepsel, S, Kosmatka, J, Faini, M, Toso, D, Aebersold, R. | | 登録日 | 2020-04-16 | | 公開日 | 2021-02-03 | | 最終更新日 | 2025-06-04 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications.
Science, 371, 2021
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7APF
 | | Crystal structure of JAK3 in complex with FM601 (compound 10a) | | 分子名称: | 1,2-ETHANEDIOL, 1-phenylurea, 3-[3-(propanoylamino)phenyl]-1~{H}-pyrrolo[2,3-b]pyridine-5-carboxamide, ... | | 著者 | Chaikuad, A, Forster, M, Gehringer, M, Laufer, S, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2020-10-16 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK.
Int J Mol Sci, 21, 2020
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6TTK
 | | Crystal structure of the kelch domain of human KLHL12 in complex with DVL1 peptide | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DVL1, ... | | 著者 | Chen, Z, Williams, E, Pike, A.C.W, Strain-Damerell, C, Wang, D, Chalk, R, Burgess-Brown, N, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N. | | 登録日 | 2019-12-27 | | 公開日 | 2020-02-12 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.383 Å) | | 主引用文献 | Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12.
Open Biology, 10, 2020
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7ZWD
 | | Structure of SNAPc containing Pol II pre-initiation complex bound to U5 snRNA promoter (CC) | | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... | | 著者 | Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. | | 登録日 | 2022-05-19 | | 公開日 | 2022-11-30 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II.
Nat.Struct.Mol.Biol., 29, 2022
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8RS0
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4ZTN
 | | Irak4-inhibitor co-structure | | 分子名称: | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3R)-piperidin-3-ylamino]pyrimidin-4(3H)-one, Interleukin-1 receptor-associated kinase 4 | | 著者 | Fischmann, T.O. | | 登録日 | 2015-05-14 | | 公開日 | 2015-09-02 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors.
Acs Med.Chem.Lett., 6, 2015
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3FNK
 | | Crystal structure of the second type II cohesin module from the cellulosomal adaptor ScaA scaffoldin of Acetivibrio cellulolyticus | | 分子名称: | 1,2-ETHANEDIOL, 1,3-PROPANDIOL, 1,4-BUTANEDIOL, ... | | 著者 | Noach, I, Frolow, F, Bayer, E.A. | | 登録日 | 2008-12-25 | | 公開日 | 2009-06-23 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Intermodular Linker Flexibility Revealed from Crystal Structures of Adjacent Cellulosomal Cohesins of Acetivibrio cellulolyticus
J.Mol.Biol., 391, 2009
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9L8I
 | | Rhodothermus marines cellobiose 2-epimerase RmCE in complex with mannobiose | | 分子名称: | CHLORIDE ION, Cellobiose 2-epimerase, PHOSPHATE ION, ... | | 著者 | Saburi, W, Muto, H, Jaito, N, Kato, K, Yu, J, Yao, M, Mori, H. | | 登録日 | 2024-12-27 | | 公開日 | 2025-07-23 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Biochemical and structural analysis of the mechanism for the catalysis and specificity of cellobiose 2-epimerase from Rhodothermus marinus.
Biosci.Biotechnol.Biochem., 89, 2025
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5M1M
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9M2F
 | | Structure of neuropeptide FF receptor 1 complex with NPFF | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Pan, B.X, Jiang, Y, Li, X.Z. | | 登録日 | 2025-02-27 | | 公開日 | 2025-07-23 | | 最終更新日 | 2025-09-03 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | Structural basis of peptide recognition and modulation for neuropeptide FF receptors.
Cell Rep, 44, 2025
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9M0R
 | | Structure of neuropeptide FF receptor 1 complex with NPVF | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Pan, B.X, Jiang, Y, Li, X.Z. | | 登録日 | 2025-02-25 | | 公開日 | 2025-07-23 | | 最終更新日 | 2025-09-03 | | 実験手法 | ELECTRON MICROSCOPY (2.47 Å) | | 主引用文献 | Structural basis of peptide recognition and modulation for neuropeptide FF receptors.
Cell Rep, 44, 2025
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3T7A
 | | Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP at pH 5.2 | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... | | 著者 | Wang, H, Falck, J, Hall, T.M.T, Shears, S.B. | | 登録日 | 2011-07-29 | | 公開日 | 2011-12-07 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
Nat.Chem.Biol., 8, 2011
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3EXU
 | | A glycoside hydrolase family 11 xylanase with an extended thumb region | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Endo-1,4-beta-xylanase, GLYCEROL | | 著者 | Vandermarliere, E, Pollet, A, Strelkov, S.V, Delcour, J.A, Courtin, C.M. | | 登録日 | 2008-10-17 | | 公開日 | 2009-08-25 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Crystallographic and activity-based evidence for thumb flexibility and its relevance in glycoside hydrolase family 11 xylanases
Proteins, 77, 2009
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6O96
 | | Dot1L bound to the H2BK120 Ubiquitinated nucleosome | | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | | 著者 | Valencia-Sanchez, M.I, De Ioannes, P.E, Miao, W, Vasilyev, N, Chen, R, Nudler, E, Armache, J.-P, Armache, K.-J. | | 登録日 | 2019-03-13 | | 公開日 | 2019-04-24 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination.
Mol.Cell, 74, 2019
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9HCH
 | | Mouse mitoribosome large subunit assembly intermediate bound to NSUN4, METRF4, GTPBP7 and the MALSU1-L0R8F8-mt-ACP complex, State C1 (SAMC knock-out) | | 分子名称: | 16S rRNA (1584-MER), 5-cytosine rRNA methyltransferase NSUN4, Acyl carrier protein, ... | | 著者 | Singh, V, Rorbach, J, Freyer, C, Amunts, A, Wredenberg, A. | | 登録日 | 2024-11-10 | | 公開日 | 2025-06-18 | | 最終更新日 | 2025-07-16 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | The mitochondrial methylation potential gates mitoribosome assembly.
Nat Commun, 16, 2025
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8RRU
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8RRW
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3F1O
 | | Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains, with an internally-bound artificial ligand | | 分子名称: | 1,2-ETHANEDIOL, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, ... | | 著者 | Scheuermann, T.H, Tomchick, D.R, Machius, M, Guo, Y, Bruick, R.K, Gardner, K.H. | | 登録日 | 2008-10-28 | | 公開日 | 2009-01-20 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.598 Å) | | 主引用文献 | Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.
Proc.Natl.Acad.Sci.USA, 106, 2009
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5XST
 | | novel orally efficacious inhibitors complexed with PARP1 | | 分子名称: | 6-fluoranyl-2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-1~{H}-benzimidazole-4-carboxamide, Poly [ADP-ribose] polymerase 1, SULFATE ION | | 著者 | Liu, Q, Xu, Y. | | 登録日 | 2017-06-15 | | 公開日 | 2018-04-25 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors
Eur J Med Chem, 145, 2018
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8AYE
 | | E. coli 70S ribosome bound to thermorubin and fMet-tRNA | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Sanyal, S, Parajuli, N.P, Emmerich, A.G. | | 登録日 | 2022-09-02 | | 公開日 | 2023-03-01 | | 最終更新日 | 2025-03-12 | | 実験手法 | ELECTRON MICROSCOPY (1.96 Å) | | 主引用文献 | Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria.
Nat Commun, 14, 2023
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