7APF
Crystal structure of JAK3 in complex with FM601 (compound 10a)
Summary for 7APF
Entry DOI | 10.2210/pdb7apf/pdb |
Descriptor | Tyrosine-protein kinase JAK3, 3-[3-(propanoylamino)phenyl]-1~{H}-pyrrolo[2,3-b]pyridine-5-carboxamide, 1-phenylurea, ... (5 entities in total) |
Functional Keywords | kinase, jak3, inhibitor, covalent inhibitor, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 68220.08 |
Authors | Chaikuad, A.,Forster, M.,Gehringer, M.,Laufer, S.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-10-16, release date: 2020-12-02, Last modification date: 2024-01-31) |
Primary citation | Forster, M.,Liang, X.J.,Schroder, M.,Gerstenecker, S.,Chaikuad, A.,Knapp, S.,Laufer, S.,Gehringer, M. Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK. Int J Mol Sci, 21:-, 2020 Cited by PubMed: 33291717DOI: 10.3390/ijms21239269 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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