7APF
Crystal structure of JAK3 in complex with FM601 (compound 10a)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase JAK3 | polymer | 294 | 33417.3 | 2 | UniProt (P52333) Pfam (PF07714) | Homo sapiens (Human) | Janus kinase 3,JAK-3,Leukocyte janus kinase,L-JAK |
| 2 | C, J (A, B) | 3-[3-(propanoylamino)phenyl]-1~{H}-pyrrolo[2,3-b]pyridine-5-carboxamide | non-polymer | 308.3 | 2 | Chemie (RQZ) | |||
| 3 | D, K (A, B) | 1-phenylurea | non-polymer | 136.2 | 2 | Chemie (PHU) | |||
| 4 | E, F, G, H, I... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 5 | O, P (A, B) | water | water | 18.0 | 300 | Chemie (HOH) |
Sequence modifications
A, B: 812 - 1103 (UniProt: P52333)
| PDB | External Database | Details |
|---|---|---|
| Ser 810 | - | expression tag |
| Met 811 | - | expression tag |
| Ala 949 | Asp 949 | conflict |
| Ser 1040 | Cys 1040 | conflict |
| Ser 1048 | Cys 1048 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66834.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1385.5 | |
| All* | Total formula weight | 68220.1 |
