3W22
 
 | | Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-125 | | 分子名称: | 5-[2-(4-tert-butylphenyl)ethyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, COBALT HEXAMMINE(III), Dihydroorotate dehydrogenase (fumarate), ... | | 著者 | Inaoka, D.K, Iida, M, Tabuchi, T, Lee, N, Matsuoka, S, Shiba, T, Sakamoto, K, Suzuki, S, Balogun, E.O, Nara, T, Aoki, T, Inoue, M, Honma, T, Tanaka, A, Harada, S, Kita, K. | | 登録日 | 2012-11-26 | | 公開日 | 2013-11-27 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-3-125
To be Published
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3RD9
 | | Human Cyclophilin D Complexed with a Fragment | | 分子名称: | 3-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide, DI(HYDROXYETHYL)ETHER, Peptidyl-prolyl cis-trans isomerase F, ... | | 著者 | Colliandre, L, Ahmed-Belkacem, H, Bessin, Y, Pawlotsky, J.M, Guichou, J.F. | | 登録日 | 2011-04-01 | | 公開日 | 2012-03-21 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
Nat Commun, 7, 2016
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2C74
 | | 14-3-3 Protein Eta (Human) Complexed to Peptide | | 分子名称: | 14-3-3 PROTEIN ETA, CITRIC ACID, CONSENSUS PEPTIDE MODE 1 FOR 14-3-3 PROTEINS | | 著者 | Elkins, J.M, Yang, X, Smee, C.E.A, Johansson, C, Sundstrom, M, Edwards, A, Weigelt, J, Arrowsmith, C, Doyle, D.A. | | 登録日 | 2005-11-17 | | 公開日 | 2005-12-02 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis for protein-protein interactions in the 14-3-3 protein family.
Proc. Natl. Acad. Sci. U.S.A., 103, 2006
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5WI0
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2XWI
 | | SiaP R147K mutant in complex with Neu5Ac | | 分子名称: | N-acetyl-beta-neuraminic acid, SIALIC ACID-BINDING PERIPLASMIC PROTEIN SIAP | | 著者 | Fischer, M, Hubbard, R.E. | | 登録日 | 2010-11-04 | | 公開日 | 2011-11-23 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.195 Å) | | 主引用文献 | Tripartite ATP-Independent Periplasmic (Trap) Transporters Use an Arginine-Mediated Selectivity Filter for High Affinity Substrate Binding.
J.Biol.Chem., 290, 2015
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2C70
 | | Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins | | 分子名称: | AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, P-NITRO-BENZYLAMINE | | 著者 | Li, M, Binda, C, Mattevi, A, Edmondson, D.E. | | 登録日 | 2005-11-17 | | 公開日 | 2006-04-19 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins
Biochemistry, 45, 2006
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6SS5
 | | Structure of the arginase-2-inhibitory human antigen-binding fragment Fab C0020187 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... | | 著者 | Burschowsky, D, Addyman, A, Fiedler, S, Groves, M, Haynes, S, Seewooruthun, C, Carr, M. | | 登録日 | 2019-09-06 | | 公開日 | 2020-06-10 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation.
Proc.Natl.Acad.Sci.USA, 117, 2020
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5HXR
 | | Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with 2.5 mM Na+ and 10mM Ca2+ | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, PENTADECANE, ... | | 著者 | Liao, J, Jiang, Y.X, Faraldo-Gomez, J.D. | | 登録日 | 2016-01-31 | | 公開日 | 2016-05-11 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.463 Å) | | 主引用文献 | Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger
Nat.Struct.Mol.Biol., 23, 2016
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4PM4
 | | Structure of a putative periplasmic iron siderophore binding protein (Rv0265c) from Mycobacterium tuberculosis H37Rv | | 分子名称: | CHLORIDE ION, Iron complex transporter substrate-binding protein, SULFATE ION | | 著者 | Arbing, M.A, Chan, S, Tran, N, Kuo, E, Lu, J, Harris, L.R, Zhou, T.T, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2014-05-20 | | 公開日 | 2014-06-11 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of a putative periplasmic iron siderophore binding protein (Rv0265c) from Mycobacterium tuberculosis H37Rv
To Be Published
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3W0O
 | | Crystal structure of a thermostable mutant of aminoglycoside phosphotransferase APH(4)-Ia, ternary complex with ADP and hygromycin B | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, HYGROMYCIN B VARIANT, Hygromycin-B 4-O-kinase | | 著者 | Iino, D, Takakura, Y, Fukano, K, Sasaki, Y, Hoshino, T, Ohsawa, K, Nakamura, A, Yajima, S. | | 登録日 | 2012-11-02 | | 公開日 | 2013-08-07 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal structures of the ternary complex of APH(4)-Ia/Hph with hygromycin B and an ATP analog using a thermostable mutant.
J.Struct.Biol., 183, 2013
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4PIQ
 | | Crystal structure of human adenovirus 8 protease with a nitrile inhibitor | | 分子名称: | N-[(3,5-dichlorophenyl)acetyl]-L-threonyl-N-[(2Z)-2-iminoethyl]glycinamide, PVI, Protease | | 著者 | Mac Sweeney, A, Grosche, P, Ellis, D, Combrink, K, Erbel, P, Hughes, N, Sirockin, F, Melkko, S, Bernardi, A, Ramage, P, Jarousse, N, Altmann, E. | | 登録日 | 2014-05-09 | | 公開日 | 2014-09-10 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Discovery and structure-based optimization of adenain inhibitors.
Acs Med.Chem.Lett., 5, 2014
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1JR1
 | | Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid | | 分子名称: | INOSINIC ACID, Inosine-5'-Monophosphate Dehydrogenase 2, MYCOPHENOLIC ACID, ... | | 著者 | Sintchak, M.D, Fleming, M.A, Futer, O, Raybuck, S.A, Chambers, S.P, Caron, P.R, Murcko, M.A, Wilson, K.P. | | 登録日 | 2001-08-09 | | 公開日 | 2001-09-05 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid.
Cell(Cambridge,Mass.), 85, 1996
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2LUU
 | | NMR solution structure of midkine-b, mdkb | | 分子名称: | Midkine-related growth factor Mdk2 | | 著者 | Yang, D, Lim, J, Meng, D. | | 登録日 | 2012-06-21 | | 公開日 | 2013-05-01 | | 最終更新日 | 2024-10-09 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure-function analysis of full-length midkine reveals novel residues important for heparin binding and zebrafish embryogenesis.
Biochem.J., 451, 2013
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8R7Z
 | | transcription factor BARHL2 homodimer with spacing four bp | | 分子名称: | BarH-like 2 homeobox protein, DNA (5'-D(P*AP*CP*CP*GP*TP*TP*TP*AP*G)-3'), DNA (5'-D(P*CP*TP*AP*AP*AP*CP*GP*GP*T)-3'), ... | | 著者 | Morgunova, E, Popov, A, Yin, Y, Taipale, J. | | 登録日 | 2023-11-27 | | 公開日 | 2024-12-04 | | 最終更新日 | 2025-04-23 | | 実験手法 | X-RAY DIFFRACTION (3.26 Å) | | 主引用文献 | DNA-guided transcription factor interactions extend human gene regulatory code.
Nature, 2025
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1NIL
 | | A COMPARISON OF NMR SOLUTION STRUCTURES OF THE RECEPTOR BINDING DOMAINS OF PSEUDOMONAS AERUGINOSA PILI STRAINS PAO, KB7, AND PAK: IMPLICATIONS FOR RECEPTOR BINDING AND SYNTHETIC VACCINE DESIGN | | 分子名称: | PAK PILIN, TRANS | | 著者 | Campbell, A.P, Mcinnes, C, Hodges, R.S, Sykes, B.D. | | 登録日 | 1995-10-05 | | 公開日 | 1996-01-29 | | 最終更新日 | 2024-10-30 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Comparison of NMR solution structures of the receptor binding domains of Pseudomonas aeruginosa pili strains PAO, KB7, and PAK: implications for receptor binding and synthetic vaccine design.
Biochemistry, 34, 1995
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2CCC
 | | Complexes of Dodecin with Flavin and Flavin-like Ligands | | 分子名称: | CHLORIDE ION, LUMIFLAVIN, MAGNESIUM ION, ... | | 著者 | Grininger, M, Zeth, K, Oesterhelt, D. | | 登録日 | 2006-01-13 | | 公開日 | 2006-01-31 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Dodecins: A Family of Lumichrome Binding Proteins.
J.Mol.Biol., 357, 2006
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4FC6
 | | Studies on DCR shed new light on peroxisomal beta-oxidation: Crystal structure of the ternary complex of pDCR | | 分子名称: | HEXANOYL-COENZYME A, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Peroxisomal 2,4-dienoyl-CoA reductase | | 著者 | Hua, T, Wu, D, Wang, J, Shaw, N, Liu, Z.-J. | | 登録日 | 2012-05-24 | | 公開日 | 2012-07-04 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Studies of human 2,4-dienoyl CoA reductase shed new light on peroxisomal beta-oxidation of unsaturated fatty acids
J.Biol.Chem., 287, 2012
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4KVU
 | | Crystal structure of a 6-helix coiled coil CC-Hex-L17C-W224BF | | 分子名称: | 6-helix coiled coil CC-Hex-L17C-W224BF, GLYCEROL | | 著者 | Burton, A.J, Agnew, C, Brady, R.L, Woolfson, D.N. | | 登録日 | 2013-05-23 | | 公開日 | 2013-08-21 | | 最終更新日 | 2025-03-26 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Accessibility, Reactivity, and Selectivity of Side Chains within a Channel of de Novo Peptide Assembly.
J.Am.Chem.Soc., 135, 2013
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2CGL
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3VRV
 | | VDR ligand binding domain in complex with 2-Methylidene-26,27-dimethyl-19,24-dinor-1alpha,25-dihydroxyvitamin D3 | | 分子名称: | (1R,3R,7E,17beta)-17-[(2R)-5-ethyl-5-hydroxyheptan-2-yl]-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, 13-meric peptide from Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor | | 著者 | Yoshimoto, N, Inaba, Y, Itoh, T, Nakabayashi, M, Ito, N, Yamamoto, K. | | 登録日 | 2012-04-14 | | 公開日 | 2012-05-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Butyl pocket formation in the vitamin d receptor strongly affects the agonistic or antagonistic behavior of ligands
J.Med.Chem., 55, 2012
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1JJ7
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2VGL
 | | AP2 CLATHRIN ADAPTOR CORE | | 分子名称: | ADAPTOR PROTEIN COMPLEX AP-2, ALPHA 2 SUBUNIT, AP-2 COMPLEX SUBUNIT BETA-1, ... | | 著者 | Owen, D.J, Collins, B.M, McCoy, A.J, Evans, P.R. | | 登録日 | 2007-11-14 | | 公開日 | 2007-12-25 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Molecular Architecture and Functional Model of the Endocytic Ap2 Complex
Cell(Cambridge,Mass.), 109, 2002
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2M4J
 | | 40-residue beta-amyloid fibril derived from Alzheimer's disease brain | | 分子名称: | Amyloid beta A4 protein | | 著者 | Lu, J, Qiang, W, Meredith, S.C, Yau, W, Schweiters, C.D, Tycko, R. | | 登録日 | 2013-02-05 | | 公開日 | 2013-09-25 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | Molecular Structure of beta-Amyloid Fibrils in Alzheimer's Disease Brain Tissue.
Cell(Cambridge,Mass.), 154, 2013
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2Y2E
 | | crystal structure of AmpD grown at pH 5.5 | | 分子名称: | 1,6-ANHYDRO-N-ACETYLMURAMYL-L-ALANINE AMIDASE AMPD, ZINC ION | | 著者 | Carrasco-Lopez, C, Rojas-Altuve, A, Zhang, W, Hesek, D, Lee, M, Barbe, S, Andre, I, Silva-Martin, N, Martinez-Ripoll, M, Mobashery, S, Hermoso, J.A. | | 登録日 | 2010-12-14 | | 公開日 | 2011-07-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structures of Bacterial Peptidoglycan Amidase Ampd and an Unprecedented Activation Mechanism.
J.Biol.Chem., 286, 2011
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3RL6
 | | Crystal structure of the archaeal asparagine synthetase A complexed with L-Asparagine and Adenosine monophosphate | | 分子名称: | ADENOSINE MONOPHOSPHATE, ASPARAGINE, Archaeal asparagine synthetase A, ... | | 著者 | Blaise, M, Frechin, M, Charron, C, Roy, H, Sauter, C, Lorber, B, Olieric, V, Kern, D. | | 登録日 | 2011-04-19 | | 公開日 | 2011-08-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of the Archaeal Asparagine Synthetase: Interrelation with Aspartyl-tRNA and Asparaginyl-tRNA Synthetases.
J.Mol.Biol., 412, 2011
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