PDB: 498 件ウェブページステータス検索Chemie searchBIRD

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3UPN	Structure of penicillin-binding protein A from M. tuberculosis: imipenem acyl-enzyme complex 分子名称: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, Penicillin-binding protein A 著者 Davies, C, Fedorovich, A. 登録日 2011-11-18 公開日 2012-10-24 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis J.Mol.Biol., 418, 2012
3UPP	Structure of penicillin-binding protein A from M. tuberculosis: ceftrixaone acyl-enzyme complex 分子名称: CEFOTAXIME, C3' cleaved, open, ... 著者 Davies, C, Fedorovich, A. 登録日 2011-11-18 公開日 2012-10-24 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis J.Mol.Biol., 418, 2012
1Z6F	Crystal structure of penicillin-binding protein 5 from E. coli in complex with a boronic acid inhibitor 分子名称: GLYCEROL, N1-[(1R)-1-(DIHYDROXYBORYL)ETHYL]-N2-[(TERT-BUTOXYCARBONYL)-D-GAMMA-GLUTAMYL]-N6-[(BENZYLOXY)CARBONYL-L-LYSINAMIDE, Penicillin-binding protein 5 著者 Nicola, G, Peddi, S, Stefanova, M, Nicholas, R.A, Gutheil, W.G, Davies, C. 登録日 2005-03-22 公開日 2005-06-21 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal Structure of Escherichia coli Penicillin-Binding Protein 5 Bound to a Tripeptide Boronic Acid Inhibitor: A Role for Ser-110 in Deacylation. Biochemistry, 44, 2005
3EQU	Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae 分子名称: GLYCEROL, Penicillin-binding protein 2, SULFATE ION 著者 Powell, A.J, Deacon, A.M, Nicholas, R.A, Davies, C. 登録日 2008-10-01 公開日 2008-10-21 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance. J.Biol.Chem., 284, 2009
3VSK	Crystal structure of penicillin-binding protein 3 (PBP3) from methicilin-resistant Staphylococcus aureus in the apo form. 分子名称: Penicillin-binding protein 3 著者 Yoshida, H, Tame, J.R, Park, S.Y. 登録日 2012-04-25 公開日 2012-10-31 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.301 Å) 主引用文献 Crystal Structures of Penicillin-Binding Protein 3 (PBP3) from Methicillin-Resistant Staphylococcus aureus in the Apo and Cefotaxime-Bound Forms. J.Mol.Biol., 423, 2012
1NZU	Wild-type penicillin-binding protein 5 from E. coli modified by beta-mercaptoethanol 分子名称: BETA-MERCAPTOETHANOL, Penicillin-binding protein 5 著者 Nicola, G, Nicholas, R.A, Davies, C. 登録日 2003-02-19 公開日 2004-03-02 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A large displacement of the SXN motif of Cys115-modified penicillin-binding protein 5 from Escherichia coli. Biochem.J., 392, 2005
1SDN	CRYSTAL STRUCTURE OF A DEACYLATION-DEFECTIVE MUTANT OF PENICILLIN-BINDING PROTEIN 5 MODIFIED BY MERCURY 分子名称: MERCURY (II) ION, Penicillin-binding protein 5 著者 Nicola, G, Nicholas, R.A, Davies, C. 登録日 2004-02-13 公開日 2005-02-22 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A large displacement of the SXN motif of Cys115-modified penicillin-binding protein 5 from Escherichia coli. Biochem.J., 392, 2005
2ZC4	Penicillin-binding protein 2X (PBP 2X) acyl-enzyme complex (tebipenem) from Streptococcus pneumoniae 分子名称: (4R,5S)-3-(1-(4,5-dihydrothiazol-2-yl)azetidin-3-ylthio)-5-((2S,3R)-3-hydroxy-1-oxobutan-2-yl)-4-methyl-4,5- dihydro-1H-pyrrole-2-carboxylic acid, Penicillin-binding protein 2X, SULFATE ION 著者 Yamada, M, Watanabe, T, Takeuchi, Y. 登録日 2007-11-02 公開日 2008-04-08 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae Antimicrob.Agents Chemother., 52, 2008
2ZC5	Penicillin-binding protein 1A (PBP 1A) acyl-enzyme complex (biapenem) from Streptococcus pneumoniae 分子名称: (4R,5S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-meth yl-4,5-dihydro-1H-pyrrole-2-carboxylate, Penicillin-binding protein 1A, ZINC ION 著者 Yamada, M, Watanabe, T, Takeuchi, Y. 登録日 2007-11-02 公開日 2008-04-08 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae Antimicrob.Agents Chemother., 52, 2008
2ZC6	Penicillin-binding protein 1A (PBP 1A) acyl-enzyme complex (tebipenem) from Streptococcus pneumoniae 分子名称: (4R,5S)-3-(1-(4,5-dihydrothiazol-2-yl)azetidin-3-ylthio)-5-((2S,3R)-3-hydroxy-1-oxobutan-2-yl)-4-methyl-4,5- dihydro-1H-pyrrole-2-carboxylic acid, Penicillin-binding protein 1A, ZINC ION 著者 Yamada, M, Watanabe, T, Takeuchi, Y. 登録日 2007-11-02 公開日 2008-04-08 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae Antimicrob.Agents Chemother., 52, 2008
2ZC3	Penicillin-binding protein 2X (PBP 2X) acyl-enzyme complex (biapenem) from Streptococcus pneumoniae 分子名称: (4R,5S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-meth yl-4,5-dihydro-1H-pyrrole-2-carboxylate, Penicillin-binding protein 2X, SULFATE ION 著者 Yamada, M, Watanabe, T, Takeuchi, Y. 登録日 2007-11-02 公開日 2008-04-08 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae Antimicrob.Agents Chemother., 52, 2008
7O4C	Crystal structure of PASTA domains of the Penicillin-Binding Protein 1 (PBP1) from Staphylococcus aureus 分子名称: CHLORIDE ION, Penicillin-binding protein 1 著者 Martinez Caballero, S, Hermoso, J.A. 登録日 2021-04-05 公開日 2021-11-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus , an essential component of the divisome machinery. Comput Struct Biotechnol J, 19, 2021
7O4A	Crystal structure of Penicillin-Binding Protein 1 (PBP1) from Staphylococcus aureus in complex with piperacillin 分子名称: Hydrolyzed piperacillin, Penicillin-binding protein 1 著者 Martinez Caballero, S, Hermoso, J.A. 登録日 2021-04-05 公開日 2021-11-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.028 Å) 主引用文献 Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus , an essential component of the divisome machinery. Comput Struct Biotechnol J, 19, 2021
7O49	Crystal structure of Penicillin-Binding Protein 1 (PBP1) from Staphylococcus aureus 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CADMIUM ION, CHLORIDE ION, ... 著者 Martinez Caballero, S, Hermoso, J.A. 登録日 2021-04-05 公開日 2021-11-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.03 Å) 主引用文献 Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus , an essential component of the divisome machinery. Comput Struct Biotechnol J, 19, 2021
5CXW	Structure of the PonA1 protein from Mycobacterium Tuberculosis in complex with penicillin V 分子名称: (2R,4S)-5,5-dimethyl-2-{(1R)-2-oxo-1-[(phenoxyacetyl)amino]ethyl}-1,3-thiazolidine-4-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... 著者 Filippova, E.V, Kiryukhina, O, Kieser, K, Endres, M, Rubin, E, Sacchettini, J, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI) 登録日 2015-07-29 公開日 2016-05-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance. Febs J., 283, 2016
7O4B	Crystal structure of Penicillin-Binding Protein 1 (PBP1) from Staphylococcus aureus in complex with penicillin G 分子名称: CITRIC ACID, OPEN FORM - PENICILLIN G, Penicillin-binding protein 1, ... 著者 Martinez Caballero, S, Hermoso, J.A. 登録日 2021-04-05 公開日 2021-11-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.593 Å) 主引用文献 Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus , an essential component of the divisome machinery. Comput Struct Biotechnol J, 19, 2021
7OK9	Crystal structure of Penicillin-Binding Protein 1 (PBP1) from Staphylococcus aureus in complex with pentaglycine 分子名称: CADMIUM ION, CHLORIDE ION, Penicillin-binding protein 1, ... 著者 Martinez Caballero, S, Hermoso, J.A. 登録日 2021-05-17 公開日 2021-11-03 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.36 Å) 主引用文献 Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus , an essential component of the divisome machinery. Comput Struct Biotechnol J, 19, 2021
5KSH	Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae containing an A501T mutation associated with cephalosporin resistance 分子名称: GLYCEROL, Penicillin-binding protein 2, SULFATE ION 著者 Fedarovich, A, Davies, C. 登録日 2016-07-08 公開日 2017-03-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness. Biochemistry, 56, 2017
2BG1	Active site restructuring regulates ligand recognition in classA Penicillin-binding proteins (PBPs) 分子名称: CHLORIDE ION, PENICILLIN-BINDING PROTEIN 1B, SULFATE ION 著者 Macheboeuf, P, Di Guilmi, A.M, Job, V, Vernet, T, Dideberg, O, Dessen, A. 登録日 2004-12-16 公開日 2005-03-11 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Active Site Restructuring Regulates Ligand Recognition in Class a Penicillin-Binding Proteins Proc.Natl.Acad.Sci.USA, 102, 2005
6MKI	Crystal structure of penicillin-binding protein 4 (PBP4) from Enterococcus faecalis in the ceftaroline-bound form 分子名称: Ceftaroline, bound form, GLYCEROL, ... 著者 D'Andrea, E.D, Moon, T.M, Peti, W, Page, R. 登録日 2018-09-25 公開日 2018-10-31 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.984 Å) 主引用文献 The structures of penicillin-binding protein 4 (PBP4) and PBP5 fromEnterococciprovide structural insights into beta-lactam resistance. J. Biol. Chem., 293, 2018
2UWX	Active site restructuring regulates ligand recognition in class A penicillin-binding proteins 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, PENICILLIN-BINDING PROTEIN 1B, ... 著者 Macheboeuf, P, DiGuilmi, A.M, Job, V, Vernet, T, Dideberg, O, Dessen, A. 登録日 2007-03-23 公開日 2007-04-03 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Active Site Restructuring Regulates Ligand Recognition in Class a Penicillin-Binding Proteins Proc.Natl.Acad.Sci.USA, 102, 2005
2XD1	ACTIVE SITE RESTRUCTURING REGULATES LIGAND RECOGNITION IN CLASS A PENICILLIN-BINDING PROTEINS 分子名称: CEFOTAXIME, C3' cleaved, open, ... 著者 Macheboeuf, P, Di Guilmi, A.M, Job, V, Vernet, T, Dideberg, O, Dessen, A. 登録日 2010-04-28 公開日 2010-05-26 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Active Site Restructuring Regulates Ligand Recognition in Class a Penicillin-Binding Proteins. Proc.Natl.Acad.Sci.USA, 102, 2005
3VSL	Crystal structure of penicillin-binding protein 3 (PBP3) from methicilin-resistant Staphylococcus aureus in the cefotaxime bound form. 分子名称: CEFOTAXIME, C3' cleaved, open, ... 著者 Yoshida, H, Tame, J.R, Park, S.Y. 登録日 2012-04-25 公開日 2012-10-31 最終更新日 2017-03-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structures of Penicillin-Binding Protein 3 (PBP3) from Methicillin-Resistant Staphylococcus aureus in the Apo and Cefotaxime-Bound Forms. J.Mol.Biol., 423, 2012
2Z2M	Cefditoren-Acylated Penicillin-Binding Protein 2X (PBP2X) from Streptococcus pneumoniae 分子名称: (2R)-2-[(1R)-1-{[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-(METHOXYIMINO)ACETYL]AMINO}-2-OXOETHYL]-5-[(Z)-2-(4-METHYL-1,3-THIAZOL-5-YL)VINYL]-3,6-DIHYDRO-2H-1,3-THIAZINE-4-CARBOXYLIC ACID, Penicillin-binding protein 2X, SULFATE ION 著者 Yamada, M, Watanabe, T, Takeuchi, Y. 登録日 2007-05-23 公開日 2007-09-04 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structure of Cefditoren Complexed with Streptococcus pneumoniae Penicillin-Binding Protein 2X: Structural Basis for its High Antimicrobial Activity Antimicrob.Agents Chemother., 51, 2007
2WAD	PENICILLIN-BINDING PROTEIN 2B (PBP-2B) FROM STREPTOCOCCUS PNEUMONIAE (STRAIN 5204) 分子名称: PENICILLIN-BINDING PROTEIN 2B, ZINC ION 著者 Contreras-Martel, C, Dahout-Gonzalez, C, Dos-Santos-Martins, A, Kotnik, M, Dessen, A. 登録日 2009-02-05 公開日 2009-02-24 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Pbp Active Site Flexibility as the Key Mechanism for Beta-Lactam Resistance in Pneumococci J.Mol.Biol., 387, 2009

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