PDB: 658 件ウェブページステータス検索Chemie searchBIRD

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2DRD	Crystal structure of a multidrug transporter reveal a functionally rotating mechanism 分子名称: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, ACRB 著者 Murakami, S, Nakashima, R, Yamashita, E, Matsumoto, T. 登録日 2006-06-08 公開日 2006-08-22 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal structures of a multidrug transporter reveal a functionally rotating mechanism Nature, 443, 2006
2DR6	Crystal structure of a multidrug transporter reveal a functionally rotating mechanism 分子名称: ACRB, DOXORUBICIN 著者 Murakami, S, Nakashima, R, Yamashita, E, Matsumoto, T. 登録日 2006-06-08 公開日 2006-08-22 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Crystal structures of a multidrug transporter reveal a functionally rotating mechanism Nature, 443, 2006
2DHH	Crystal structure of a multidrug transporter reveal a functionally rotating mechanism 分子名称: ACRB 著者 Murakami, S, Nakashima, R, Yamashita, E, Matsumoto, T. 登録日 2006-03-23 公開日 2006-08-22 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structures of a multidrug transporter reveal a functionally rotating mechanism Nature, 443, 2006
5JMN	Fusidic acid bound AcrB 分子名称: 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15-PENTAOXAHEPTADECANE, DARPin, ... 著者 Oswald, C, Tam, H.K, Pos, K.M. 登録日 2016-04-29 公開日 2016-12-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB. Nat Commun, 7, 2016
5KPD	Mouse pgp 34 linker deleted double EQ mutant 分子名称: Multidrug resistance protein 1A 著者 Xia, D, Esser, L, Zhou, F. 登録日 2016-07-03 公開日 2016-11-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292, 2017
5KPI	Mouse native PGP 分子名称: Multidrug resistance protein 1A 著者 Xia, D, Esser, L, Zhou, F. 登録日 2016-07-04 公開日 2016-11-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.01 Å) 主引用文献 Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292, 2017
5KPJ	Mouse pgp methylated protein 分子名称: Multidrug resistance protein 1A 著者 Xia, D, Esser, L, Zhou, F. 登録日 2016-07-04 公開日 2016-11-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292, 2017
8BWR	Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (in complex with prostaglandin E2) 分子名称: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, ATP-binding cassette sub-family C member 4 著者 Raj, I, Bloch, M, Pape, T.H, Taylor, N.M.I. 登録日 2022-12-07 公開日 2023-08-30 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4. Structure, 31, 2023
8BJF	Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (inward-facing conformation) 分子名称: ATP-binding cassette sub-family C member 4, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE 著者 Raj, I, Bloch, M, Pape, T.H, Taylor, N.M.I. 登録日 2022-11-04 公開日 2023-08-30 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4. Structure, 31, 2023
8BWQ	Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (in complex with topotecan) 分子名称: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ATP-binding cassette sub-family C member 4 著者 Raj, I, Bloch, M, Pape, T.H, Taylor, N.M.I. 登録日 2022-12-07 公開日 2023-08-30 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4. Structure, 31, 2023
8BWP	Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (in complex with methotrexate) 分子名称: ATP-binding cassette sub-family C member 4, METHOTREXATE 著者 Raj, I, Bloch, M, Pape, T.H, Taylor, N.M.I. 登録日 2022-12-07 公開日 2023-08-30 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4. Structure, 31, 2023
8BWO	Cryo-EM structure of nanodisc-reconstituted human MRP4 with E1202Q mutation (outward-facing occluded conformation) 分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 4, MAGNESIUM ION 著者 Raj, I, Bloch, M, Pape, T.H, Taylor, N.M.I. 登録日 2022-12-07 公開日 2023-08-30 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4. Structure, 31, 2023
6T1Z	LmrP from L. lactis, in an outward-open conformation, bound to Hoechst 33342 分子名称: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE, 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, DODECYL-ALPHA-D-MALTOSIDE, ... 著者 Hutchin, A, Debruycker, V, Masureel, M, Legrand, P, Remaut, H, Govaerts, C. 登録日 2019-10-07 公開日 2020-07-29 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity. Nat.Struct.Mol.Biol., 27, 2020
3B5D	EmrE multidrug transporter in complex with TPP, C2 crystal form 分子名称: Multidrug transporter emrE, TETRAPHENYLPHOSPHONIUM 著者 Chang, G, Chen, Y.J. 登録日 2007-10-25 公開日 2007-12-04 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 X-ray structure of EmrE supports dual topology model. Proc.Natl.Acad.Sci.Usa, 104, 2007
3B61	EmrE multidrug transporter, apo crystal form 分子名称: Multidrug transporter emrE 著者 Chang, G, Chen, Y.J. 登録日 2007-10-26 公開日 2007-12-04 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 X-ray structure of EmrE supports dual topology model. Proc.Natl.Acad.Sci.Usa, 104, 2007
3B62	EmrE multidrug transporter in complex with P4P, P21 crystal form 分子名称: Multidrug transporter emrE, TETRAPHENYLPHOSPHONIUM 著者 Chang, G, Chen, Y.J. 登録日 2007-10-26 公開日 2007-12-04 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (4.4 Å) 主引用文献 X-ray structure of EmrE supports dual topology model. Proc.Natl.Acad.Sci.Usa, 104, 2007
2HYD	Multidrug ABC transporter SAV1866 分子名称: ABC transporter homolog, ADENOSINE-5'-DIPHOSPHATE, SODIUM ION 著者 Dawson, R.J.P, Locher, K.P. 登録日 2006-08-05 公開日 2006-09-05 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of a bacterial multidrug ABC transporter. Nature, 443, 2006
5KO2	Mouse pgp 34 linker deleted mutant Hg derivative 分子名称: MERCURY (II) ION, Multidrug resistance protein 1A 著者 Xia, D, Esser, L, Zhou, F. 登録日 2016-06-29 公開日 2016-11-30 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292, 2017
5KOY	Mouse pgp 34 linker deleted bound with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Multidrug resistance protein 1A 著者 Xia, D, Esser, L, Zhou, F. 登録日 2016-07-01 公開日 2016-12-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.85 Å) 主引用文献 Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292, 2017
5NIV	Crystal structure of 5D3 Fab 分子名称: Heavy chain of 5D3 Fab, Light chain of 5D3 Fab 著者 Manolaridis, I, Locher, K.P. 登録日 2017-03-27 公開日 2017-06-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.498 Å) 主引用文献 Structure of the human multidrug transporter ABCG2. Nature, 546, 2017
8BHT	ABCG2 turnover-1 state with tariquidar bound 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ... 著者 Yu, Q, Kowal, J, Tajkhorshid, E, Locher, K.P. 登録日 2022-10-31 公開日 2023-01-11 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2. Proc.Natl.Acad.Sci.USA, 120, 2023
8BI0	ABCG2 turnover-2 state with tariquidar bound 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ... 著者 Yu, Q, Kowal, J, Tajkhorshid, E, Locher, K.P. 登録日 2022-11-01 公開日 2023-01-11 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2. Proc.Natl.Acad.Sci.USA, 120, 2023
7A69	Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and vincristine 分子名称: CHOLESTEROL, MRK16 Fab-fragment heavy chain, MRK16 Fab-fragment light chain, ... 著者 Nosol, K, Locher, K.P. 登録日 2020-08-25 公開日 2020-10-21 最終更新日 2020-10-28 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1. Proc.Natl.Acad.Sci.USA, 117, 2020
7A6F	Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and zosuquidar 分子名称: CHOLESTEROL, MRK16 Fab-fragment heavy chain, MRK16 Fab-fragment light chain, ... 著者 Nosol, K, Locher, K.P. 登録日 2020-08-25 公開日 2020-10-14 最終更新日 2020-10-28 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1. Proc.Natl.Acad.Sci.USA, 117, 2020
7A65	Nanodisc reconstituted, drug-free human ABCB1 in complex with MRK16 Fab 分子名称: CHOLESTEROL, MRK16 Fab-fragment heavy chain, MRK16 Fab-fragment light chain, ... 著者 Nosol, K, Locher, K.P. 登録日 2020-08-25 公開日 2020-10-14 最終更新日 2020-10-28 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1. Proc.Natl.Acad.Sci.USA, 117, 2020

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