PDB: 79 件ウェブページステータス検索Chemie searchBIRD

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8FYJ	Structure of HIV-1 BG505 SOSIP-HT2 in complex with two CD4 molecules (class I) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... 著者 Fan, C, Dam, K.A, Bjorkman, P.J. 登録日 2023-01-26 公開日 2023-10-18 最終更新日 2023-12-13 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Intermediate conformations of CD4-bound HIV-1 Env heterotrimers. Nature, 623, 2023
4H8W	Crystal structure of non-neutralizing and ADCC-potent antibody N5-i5 in complex with HIV-1 clade A/E gp120 and sCD4. 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB HEAVY CHAIN OF ADCC AND NON-NEUTRALIZING ANTI-HIV-1 ANTIBODY N5-I5, ... 著者 Tolbert, W.D, Acharya, P, Kwong, P.D, Pazgier, M. 登録日 2012-09-24 公開日 2014-04-09 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection. J.Virol., 88, 2014
4JM2	Crystal Structure of PGT 135 Fab in Complex with gp120 Core Protein from HIV-1 Strain JR-FL Bound to CD4 and 17b Fab 分子名称: 17b Heavy chain, 17b Light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kong, L, Wilson, I.A. 登録日 2013-03-13 公開日 2013-05-29 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120. Nat.Struct.Mol.Biol., 20, 2013
1CDJ	STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4 分子名称: T-CELL SURFACE GLYCOPROTEIN CD4 著者 Wu, H, Myszka, D, Tendian, S.W, Brouillette, C.G, Sweet, R.W, Chaiken, I.M, Hendrickson, W.A. 登録日 1996-11-11 公開日 1997-04-01 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding. Proc.Natl.Acad.Sci.USA, 93, 1996
1CDH	STRUCTURES OF AN HIV AND MHC BINDING FRAGMENT FROM HUMAN CD4 AS REFINED IN TWO CRYSTAL LATTICES 分子名称: T CELL SURFACE GLYCOPROTEIN CD4 著者 Ryu, S.E, Truneh, A, Sweet, R.W, Hendrickson, W.A. 登録日 1994-01-26 公開日 1994-04-30 最終更新日 2019-08-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices. Structure, 2, 1994
6L1Y	structure of gp120/CD4 with a non-canonical surface 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, T-cell surface glycoprotein CD4, ... 著者 Liu, X, Ning, W. 登録日 2019-10-01 公開日 2020-05-20 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.469 Å) 主引用文献 A non-canonical binding interface in the crystal structure of HIV-1 gp120 core in complex with CD4. Sci Rep, 7, 2017
6U0N	Asymmetrically open conformational state (Class II) of HIV-1 Env trimer BG505 SOSIP.664 in complex with sCD4 and E51 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, E51 Fab heavy chain, ... 著者 Yang, Z, Bjorkman, P.J. 登録日 2019-08-14 公開日 2019-12-11 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody. Nat.Struct.Mol.Biol., 26, 2019
5CAY	Envelope glycoprotein gp120 core from HIV type 2 bound to the first two domains of human soluble CD4 receptor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120 core from ST strain of HIV-2, ... 著者 Davenport, Y.W, Bjorkman, P.J. 登録日 2015-06-30 公開日 2015-12-09 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of an HIV-2 gp120 in Complex with CD4. J.Virol., 90, 2015
6TYB	Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... 著者 Gorman, J, Kwong, P.D. 登録日 2019-08-08 公開日 2019-10-02 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.301 Å) 主引用文献 Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields. Immunity, 51, 2019
5U1F	Initial contact of HIV-1 Env with CD4: Cryo-EM structure of BG505 DS-SOSIP trimer in complex with CD4 and antibody PGT145 分子名称: BG505 DS-SOSIP gp120, BG505 SOSIP gp41, PGT145 heavy chain, ... 著者 Acharya, P, Kwong, P.D, Potter, C.S, Carragher, B. 登録日 2016-11-28 公開日 2017-02-22 最終更新日 2018-10-03 実験手法 ELECTRON MICROSCOPY (6.8 Å) 主引用文献 Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer. Nat. Struct. Mol. Biol., 24, 2017
6U0L	Asymmetrically open conformational state (Class I) of HIV-1 Env trimer BG505 SOSIP.664 in complex with sCD4 and E51 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, E51 Fab heavy chain, ... 著者 Yang, Z, Bjorkman, P.J. 登録日 2019-08-14 公開日 2019-12-11 最終更新日 2022-02-16 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody. Nat.Struct.Mol.Biol., 26, 2019
3T0E	Crystal structure of a complete ternary complex of T cell receptor, peptide-MHC and CD4 分子名称: HLA class II histocompatibility antigen, DR alpha chain, DRB1-4 beta chain, ... 著者 Yin, Y, Mariuzza, R.A. 登録日 2011-07-20 公開日 2012-03-07 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4. Proc.Natl.Acad.Sci.USA, 109, 2012
6MET	Structural basis of coreceptor recognition by HIV-1 envelope spike 分子名称: 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Shaik, M.M, Chen, B. 登録日 2018-09-07 公開日 2018-12-12 最終更新日 2024-10-09 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Structural basis of coreceptor recognition by HIV-1 envelope spike. Nature, 565, 2018
5THR	Cryo-EM structure of a BG505 Env-sCD4-17b-8ANC195 complex 分子名称: 17b Fab VH domain, 17b Fab VL domain, 8ANC195 G52K5 VH domain, ... 著者 Wang, H, Bjorkman, P.J. 登録日 2016-09-30 公開日 2016-11-16 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (8.9 Å) 主引用文献 Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop. Proc.Natl.Acad.Sci.USA, 113, 2016
5A8H	cryo-ET subtomogram averaging of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB OF BROADLY NEUTRALIZING ANTIBODY 17B, FAB OF BROADLY NEUTRALIZING ANTIBODY 8ANC195 VARIANT G52K5, ... 著者 Scharf, L, Wang, H, Gao, H, Chen, S, McDowall, A, Bjorkman, P. 登録日 2015-07-15 公開日 2015-08-05 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (23 Å) 主引用文献 Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env. Cell, 162, 2015
5A7X	negative stain EM of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB OF BROADLY NEUTRALIZING ANTIBODY 17B, FAB OF BROADLY NEUTRALIZING ANTIBODY 8ANC195, ... 著者 Scharf, L, Wang, H, Gao, H, Chen, S, McDowall, A, Bjorkman, P. 登録日 2015-07-10 公開日 2015-08-05 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (17 Å) 主引用文献 Broadly Neutralizing Antibody 8Anc195 Recognizes Closed and Open States of HIV-1 Env. Cell(Cambridge,Mass.), 162, 2015
6MEO	Structural basis of coreceptor recognition by HIV-1 envelope spike 分子名称: 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Shaik, M.M, Chen, B. 登録日 2018-09-06 公開日 2018-12-12 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural basis of coreceptor recognition by HIV-1 envelope spike. Nature, 565, 2018
3S4S	Crystal structure of CD4 mutant bound to HLA-DR1 分子名称: GLYCEROL, HLA class II histocompatibility antigen, DR alpha chain, ... 著者 Li, Y. 登録日 2011-05-20 公開日 2011-09-21 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex. Proc.Natl.Acad.Sci.USA, 108, 2011
5VN3	Cryo-EM model of B41 SOSIP.664 in complex with soluble CD4 (D1-D2) and fragment antigen binding variable domain of 17b 分子名称: 17b Fab heavy chain, 17b Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Ozorowski, G, Pallesen, J, Ward, A.B. 登録日 2017-04-28 公開日 2017-07-12 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike. Nature, 547, 2017
3S5L	Crystal structure of CD4 mutant bound to HLA-DR1 分子名称: GLYCEROL, HA peptide, HLA class II histocompatibility antigen DR beta chain, ... 著者 Li, Y. 登録日 2011-05-23 公開日 2011-09-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex. Proc.Natl.Acad.Sci.USA, 108, 2011
1CDU	STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4 MUTANT WITH PHE 43 REPLACED BY VAL 分子名称: T-CELL SURFACE GLYCOPROTEIN CD4 著者 Wu, H, Myszka, D, Tendian, S.W, Brouillette, C.G, Sweet, R.W, Chaiken, I.M, Hendrickson, W.A. 登録日 1996-11-11 公開日 1997-04-01 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding. Proc.Natl.Acad.Sci.USA, 93, 1996
1CDI	STRUCTURES OF AN HIV AND MHC BINDING FRAGMENT FROM HUMAN CD4 AS REFINED IN TWO CRYSTAL LATTICES 分子名称: T CELL SURFACE GLYCOPROTEIN CD4 著者 Ryu, S.E, Truneh, A, Sweet, R.W, Hendrickson, W.A. 登録日 1994-01-26 公開日 1994-04-30 最終更新日 2019-08-14 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices. Structure, 2, 1994
1CDY	STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4 MUTANT WITH GLY 47 REPLACED BY SER 分子名称: T-CELL SURFACE GLYCOPROTEIN CD4 著者 Wu, H, Myszka, D, Tendian, S.W, Brouillette, C.G, Sweet, R.W, Chaiken, I.M, Hendrickson, W.A. 登録日 1996-11-11 公開日 1997-04-01 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding. Proc.Natl.Acad.Sci.USA, 93, 1996
6OPO	Symmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with DDM 分子名称: 17b Fab heavy chain, 17b Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Ozorowski, G, Torres, J.L, Ward, A.B. 登録日 2019-04-25 公開日 2020-10-21 最終更新日 2024-10-09 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide. Cell Rep, 33, 2020
6OPN	CD4- and 17-bound HIV-1 Env B41 SOSIP in complex with small molecule GO35 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... 著者 Ozorowski, G, Torres, J.L, Ward, A.B. 登録日 2019-04-25 公開日 2020-10-21 最終更新日 2020-12-09 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide. Cell Rep, 33, 2020

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