5U1F

Initial contact of HIV-1 Env with CD4: Cryo-EM structure of BG505 DS-SOSIP trimer in complex with CD4 and antibody PGT145

Summary for 5U1F

• Entry DOI: 10.2210/pdb5u1f/pdb
• EMDB information: 8427
• Descriptor: BG505 DS-SOSIP gp120, BG505 SOSIP gp41, PGT145 heavy chain, ... (5 entities in total)
• Functional Keywords: hiv-1 entry early intermediate, cd4 binding site, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1 (HIV-1); More
• Total number of polymer chains: 9
• Total formula weight: 323692.03

Authors

Acharya, P.,Kwong, P.D.,Potter, C.S.,Carragher, B. (deposition date: 2016-11-28, release date: 2017-02-22, Last modification date: 2018-10-03)

• Primary citation: Liu, Q.,Acharya, P.,Dolan, M.A.,Zhang, P.,Guzzo, C.,Lu, J.,Kwon, A.,Gururani, D.,Miao, H.,Bylund, T.,Chuang, G.Y.,Druz, A.,Zhou, T.,Rice, W.J.,Wigge, C.,Carragher, B.,Potter, C.S.,Kwong, P.D.,Lusso, P.; Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer.; Nat. Struct. Mol. Biol., 24:370-378, 2017; PubMed: 28218750; DOI: 10.1038/nsmb.3382

Experimental method

ELECTRON MICROSCOPY (6.8 Å)