5U1F
Initial contact of HIV-1 Env with CD4: Cryo-EM structure of BG505 DS-SOSIP trimer in complex with CD4 and antibody PGT145
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (C, D, A) | BG505 DS-SOSIP gp120 | polymer | 501 | 55875.5 | 3 | UniProt (Q2N0S6) Pfam (PF00516) | Human immunodeficiency virus 1 (HIV-1) | |
| 2 | D, E, F (B, E, F) | BG505 SOSIP gp41 | polymer | 178 | 20202.2 | 3 | UniProt (Q2N0S6) Pfam (PF00517) | Human immunodeficiency virus 1 (HIV-1) | |
| 3 | G (H) | PGT145 heavy chain | polymer | 267 | 28953.3 | 1 | Homo sapiens (Human) | ||
| 4 | H (L) | PGT145 light chain | polymer | 239 | 26050.3 | 1 | Homo sapiens (Human) | ||
| 5 | I (M) | T-cell surface glycoprotein CD4 | polymer | 363 | 40455.5 | 1 | UniProt (P01730) Pfam (PF00047) Pfam (PF05790) Pfam (PF09191) | Homo sapiens (Human) | T-cell surface antigen T4/Leu-3 |
Sequence modifications
C, D, A: 30 - 505 (UniProt: Q2N0S6)
B, E, F: 511 - 664 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Ser 3 | - | expression tag |
| Arg 4 | - | expression tag |
| Ala 5 | - | expression tag |
| Thr 6 | - | expression tag |
| Met 7 | - | expression tag |
| Pro 8 | - | expression tag |
| Met 9 | - | expression tag |
| Gly 10 | - | expression tag |
| Ser 11 | - | expression tag |
| Leu 12 | - | expression tag |
| Gln 13 | - | expression tag |
| Pro 14 | - | expression tag |
| Leu 15 | - | expression tag |
| Ala 16 | - | expression tag |
| Thr 17 | - | expression tag |
| Leu 18 | - | expression tag |
| Tyr 19 | - | expression tag |
| Leu 20 | - | expression tag |
| Leu 21 | - | expression tag |
| Gly 22 | - | expression tag |
| Met 23 | - | expression tag |
| Leu 24 | - | expression tag |
| Val 25 | - | expression tag |
| Ala 26 | - | expression tag |
| Ser 27 | - | expression tag |
| Val 28 | - | expression tag |
| Leu 29 | - | expression tag |
| Cys 201 | Ile 200 | conflict |
| Asn 332 | Thr 330 | conflict |
| Cys 433 | Ala 430 | conflict |
| Cys 501 | Ala 498 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Val 504 | - | expression tag |
| Gly 505 | - | expression tag |
| Arg 506 | - | expression tag |
| Arg 507 | - | expression tag |
| Arg 508 | - | expression tag |
| Arg 509 | - | expression tag |
| Arg 510 | - | expression tag |
| Pro 559 | Ile 556 | conflict |
| Cys 605 | Thr 602 | conflict |
| Gly 665 | - | expression tag |
| Ser 666 | - | expression tag |
| Ala 667 | - | expression tag |
| Pro 668 | - | expression tag |
| Thr 669 | - | expression tag |
| Lys 670 | - | expression tag |
| Ala 671 | - | expression tag |
| Lys 672 | - | expression tag |
| Arg 673 | - | expression tag |
| Arg 674 | - | expression tag |
| Val 675 | - | expression tag |
| Val 676 | - | expression tag |
| Gln 677 | - | expression tag |
| Arg 678 | - | expression tag |
| Glu 679 | - | expression tag |
| Lys 680 | - | expression tag |
| Arg 681 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 323692.0 | |
| All* | Total formula weight | 323692.0 |
