5CAY

Envelope glycoprotein gp120 core from HIV type 2 bound to the first two domains of human soluble CD4 receptor

Summary for 5CAY

• Entry DOI: 10.2210/pdb5cay/pdb
• Descriptor: Envelope glycoprotein gp120 core from ST strain of HIV-2, T-cell surface glycoprotein CD4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: hiv-2, gp120, glycoprotein, cd4, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus type 2 (ISOLATE ST); More
• Total number of polymer chains: 2
• Total formula weight: 63966.80

Authors

Davenport, Y.W.,Bjorkman, P.J. (deposition date: 2015-06-30, release date: 2015-12-09, Last modification date: 2024-10-09)

Primary citation

Davenport, Y.W.,West, A.P.,Bjorkman, P.J.
Structure of an HIV-2 gp120 in Complex with CD4.
J.Virol., 90:2112-2118, 2015

PubMed Abstract: HIV-2 is a nonpandemic form of the virus causing AIDS, and the majority of HIV-2-infected patients exhibit long-term nonprogression. The HIV-1 and HIV-2 envelope glycoproteins, the sole targets of neutralizing antibodies, share 30 to 40% identity. As a first step in understanding the reduced pathogenicity of HIV-2, we solved a 3.0-Å structure of an HIV-2 gp120 bound to the host receptor CD4, which reveals structural similarity to HIV-1 gp120 despite divergence in amino acid sequence.

PubMed: 26608312
DOI: 10.1128/JVI.02678-15

Experimental method

X-RAY DIFFRACTION (3 Å)