PDB: 86 件ウェブページステータス検索Chemie searchBIRD

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6WQH	Molecular basis for the ATPase-powered substrate translocation by the Lon AAA+ protease 分子名称: ADENOSINE-5'-DIPHOSPHATE, Ig2 substrate, Lon protease, ... 著者 Zhang, K, Li, S, Hsiehb, K, Sub, S, Pintilie, G, Chiu, W, Chang, C. 登録日 2020-04-28 公開日 2021-06-09 最終更新日 2021-11-17 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease. J.Biol.Chem., 297, 2021
5FQD	Structural basis of Lenalidomide induced CK1a degradation by the crl4crbn ubiquitin ligase 分子名称: CASEIN KINASE I ISOFORM ALPHA, DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, ... 著者 Petzold, G, Fischer, E.S, Thoma, N.H. 登録日 2015-12-09 公開日 2016-02-24 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural Basis of Lenalidomide-Induced Ck1Alpha Degradation by the Crl4(Crbn) Ubiquitin Ligase. Nature, 532, 2016
7LPS	Crystal structure of DDB1-CRBN-ALV1 complex bound to Helios (IKZF2 ZF2) 分子名称: 3-[3-[[1-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2,5-bis(oxidanylidene)pyrrol-3-yl]amino]phenyl]-~{N}-(3-chloranyl-4-methyl-phenyl)propanamide, DNA damage-binding protein 1, Protein cereblon, ... 著者 Nowak, R.P, Fischer, E.S. 登録日 2021-02-12 公開日 2021-06-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.78 Å) 主引用文献 Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat.Chem.Biol., 17, 2021
8G66	Structure with SJ3149 分子名称: (3S)-3-{5-[(1,2-benzoxazol-3-yl)amino]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}piperidine-2,6-dione, Casein kinase I isoform alpha, DNA damage-binding protein 1, ... 著者 Miller, D.J, Young, S.M, Fischer, M. 登録日 2023-02-14 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Structure of ternary complex with molecular glue targeting CK1A for degradation by the CRL4CRBN ubiquitin ligase To Be Published
9CC3	Human Mitochondrial LONP1 Stall State + casein 分子名称: ADENOSINE-5'-DIPHOSPHATE, Endogenous Co-purified substrate modeled as unknown residues, Lon protease homolog, ... 著者 Mindrebo, J.T, Lander, G.C. 登録日 2024-06-20 公開日 2024-08-07 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Structural and mechanistic studies on human LONP1 redefine the hand-over-hand translocation mechanism. Biorxiv, 2024
9CC0	Human Mitochondrial LONP1 Degrading Casein, ATP-bound closed form 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Bound substrate segment undergoing translocation and subsequent degradation, ... 著者 Mindrebo, J.T, Lander, G.C. 登録日 2024-06-20 公開日 2024-08-07 実験手法 ELECTRON MICROSCOPY (3.31 Å) 主引用文献 Structural and mechanistic studies on human LONP1 redefine the hand-over-hand translocation mechanism. Biorxiv, 2024
6U5Z	Cryo-EM structure of E. coli LonA S679A 分子名称: Lon protease 著者 Botos, I, Lountos, G.T, Weimin, W, Wlodawer, A. 登録日 2019-08-28 公開日 2020-02-26 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery Curr Res Struct Biol, 1, 2020
6UML	Structural Basis for Thalidomide Teratogenicity Revealed by the Cereblon-DDB1-SALL4-Pomalidomide Complex 分子名称: DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ... 著者 Clayton, T.L, Matyskiela, M.E, Pagarigan, B.E, Tran, E.T, Chamberlain, P.P. 登録日 2019-10-09 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.58 Å) 主引用文献 Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex. Nat.Struct.Mol.Biol., 27, 2020
7SXO	Yeast Lon (PIM1) with endogenous substrate 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... 著者 Yang, J, Song, A.S, Wiseman, R.L, Lander, G.C. 登録日 2021-11-24 公開日 2022-01-12 最終更新日 2022-07-27 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements. J.Biol.Chem., 298, 2022
7U8F	Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2) and the molecular glue DKY709 分子名称: (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA damage-binding protein 1, ... 著者 Ma, X, Ornelas, E, Clifton, M.C. 登録日 2022-03-08 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. Cell Chem Biol, 30, 2023
6H0F	Structure of DDB1-CRBN-pomalidomide complex bound to IKZF1(ZF2) 分子名称: DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1, DNA-binding protein Ikaros, Protein cereblon, ... 著者 Petzold, G, Bunker, R.D, Thoma, N.H. 登録日 2018-07-09 公開日 2018-11-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science, 362, 2018
6H0G	Structure of the DDB1-CRBN-pomalidomide complex bound to ZNF692(ZF4) 分子名称: DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DDB1 (DNA damage binding protein 1),DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ... 著者 Bunker, R.D, Petzold, G, Thoma, N.H. 登録日 2018-07-09 公開日 2018-11-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (4.25 Å) 主引用文献 Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science, 362, 2018
8OM7	Human Mitochondrial Lon Y186E Mutant ADP Bound 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial 著者 Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E. 登録日 2023-03-31 公開日 2024-04-10 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.74 Å) 主引用文献 Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions. Sci Rep, 14, 2024
8OVF	Human Mitochondrial Lon Y186F Mutant ADP Bound 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial 著者 Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E. 登録日 2023-04-26 公開日 2024-05-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (7.23 Å) 主引用文献 Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions. Sci Rep, 14, 2024
8OVG	Human Mitochondrial Lon Y186E Mutant ADP Bound 分子名称: Lon protease homolog, mitochondrial 著者 Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E. 登録日 2023-04-26 公開日 2024-05-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (8.47 Å) 主引用文献 Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions. Sci Rep, 14, 2024
6BN7	Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET23 PROTAC. 分子名称: Bromodomain-containing protein 4, DNA damage-binding protein 1, Protein cereblon, ... 著者 Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S. 登録日 2017-11-16 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.501 Å) 主引用文献 Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
6BN9	Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET70 PROTAC 分子名称: Bromodomain-containing protein 4, DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, ... 著者 Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S. 登録日 2017-11-16 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.382 Å) 主引用文献 Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
6BNB	Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET57 PROTAC 分子名称: Bromodomain-containing protein 4, DNA damage-binding protein 1, Protein cereblon, ... 著者 Nowak, R.P, DeAngelo, S.L, Buckley, D, Ishoey, M, He, Z, Zhang, T, Bradner, J.E, Fischer, E.S. 登録日 2017-11-16 公開日 2018-05-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (6.343 Å) 主引用文献 Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
6BOY	Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET6 PROTAC. 分子名称: 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(8-{[({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)acetyl]amino}octyl)acetamide, Bromodomain-containing protein 4, DNA damage-binding protein 1, ... 著者 Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S. 登録日 2017-11-21 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.33 Å) 主引用文献 Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
7FD4	A complete three-dimensional structure of the Lon protease translocating a protein substrate (conformation 1) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Alpha-S1-casein, Lon protease, ... 著者 Li, S, Hsieh, K, Kuo, C, Lee, S, Pintilie, G, Zhang, K, Chang, C. 登録日 2021-07-16 公開日 2021-11-03 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Complete three-dimensional structures of the Lon protease translocating a protein substrate. Sci Adv, 7, 2021
7FD5	A complete three-dimensional structure of the Lon protease translocating a protein substrate (conformation 2) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Alpha-S1-casein, Lon protease, ... 著者 Li, S, Hsieh, K, Kuo, C, Lee, S, Pintilie, G, Zhang, K, Chang, C. 登録日 2021-07-16 公開日 2021-11-03 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Complete three-dimensional structures of the Lon protease translocating a protein substrate. Sci Adv, 7, 2021
7FID	Processive cleavage of substrate at individual proteolytic active sites of the Lon proteasecomplex (conformation 1) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. 登録日 2021-07-31 公開日 2021-11-24 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.44 Å) 主引用文献 Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
7FIZ	Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex (conformation 3) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. 登録日 2021-08-01 公開日 2021-11-24 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.28 Å) 主引用文献 Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
7FIE	Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex (conformation 2) 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Li, S, Hsieh, K, Kuo, C, Su, S, Huang, K, Zhang, K, Chang, C.I. 登録日 2021-07-31 公開日 2021-11-24 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.36 Å) 主引用文献 Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv, 7, 2021
8K3Y	The "5+1" heteromeric structure of Lon protease consisting of a spiral pentamer with Y224S mutation and an N-terminal-truncated monomeric E613K mutant 分子名称: ADENOSINE-5'-DIPHOSPHATE, Lon protease 著者 Li, S, Hsieh, K.Y, Kuo, C.I, Zhang, K, Chang, C.I. 登録日 2023-07-17 公開日 2023-10-25 最終更新日 2023-11-29 実験手法 ELECTRON MICROSCOPY (4.42 Å) 主引用文献 A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun, 14, 2023

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