6UML

Structural Basis for Thalidomide Teratogenicity Revealed by the Cereblon-DDB1-SALL4-Pomalidomide Complex

Summary for 6UML

Entry DOI	10.2210/pdb6uml/pdb
Descriptor	DNA damage-binding protein 1, Protein cereblon, Sal-like protein 4, ... (5 entities in total)
Functional Keywords	celmod, cereblon-crl4, ubiquitin ligase, c2h2 zinc finger, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	177358.87
Authors	Clayton, T.L.,Matyskiela, M.E.,Pagarigan, B.E.,Tran, E.T.,Chamberlain, P.P. (deposition date: 2019-10-09, release date: 2020-04-15, Last modification date: 2023-10-11)
Primary citation	Matyskiela, M.E.,Clayton, T.,Zheng, X.,Mayne, C.,Tran, E.,Carpenter, A.,Pagarigan, B.,McDonald, J.,Rolfe, M.,Hamann, L.G.,Lu, G.,Chamberlain, P.P. Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex. Nat.Struct.Mol.Biol., 27:319-322, 2020 Cited by PubMed: 32251415 DOI: 10.1038/s41594-020-0405-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.58 Å)

Structure validation