6UML
Structural Basis for Thalidomide Teratogenicity Revealed by the Cereblon-DDB1-SALL4-Pomalidomide Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | DNA damage-binding protein 1 | polymer | 1140 | 127097.5 | 1 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) In PDB | Homo sapiens (Human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
| 2 | C | Protein cereblon | polymer | 406 | 46596.6 | 1 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) In PDB | Homo sapiens (Human) | |
| 3 | E | Sal-like protein 4 | polymer | 28 | 3260.8 | 1 | UniProt (Q9UJQ4) Pfam (PF00096) In PDB | Homo sapiens (Human) | Zinc finger protein 797,Zinc finger protein SALL4 |
| 4 | C, E | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | C | S-Pomalidomide | non-polymer | 273.2 | 1 | Chemie (Y70) |
Sequence modifications
C: 40 - 442 (UniProt: Q96SW2)
| PDB | External Database | Details |
|---|---|---|
| Gly 37 | - | expression tag |
| Ser 38 | - | expression tag |
| Met 39 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 176954.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 404.1 | |
| All* | Total formula weight | 177358.9 |
