7LPS

Crystal structure of DDB1-CRBN-ALV1 complex bound to Helios (IKZF2 ZF2)

Summary for 7LPS

Entry DOI	10.2210/pdb7lps/pdb
Descriptor	DNA damage-binding protein 1, Protein cereblon, Zinc finger protein Helios, ... (5 entities in total)
Functional Keywords	crbn, ddb1, ikzf2, alv, degradation, e3 ligase, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	703337.26
Authors	Nowak, R.P.,Fischer, E.S. (deposition date: 2021-02-12, release date: 2021-06-02, Last modification date: 2023-10-18)
Primary citation	Wang, E.S.,Verano, A.L.,Nowak, R.P.,Yuan, J.C.,Donovan, K.A.,Eleuteri, N.A.,Yue, H.,Ngo, K.H.,Lizotte, P.H.,Gokhale, P.C.,Gray, N.S.,Fischer, E.S. Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat.Chem.Biol., 17:711-717, 2021 Cited by PubMed: 34035522 DOI: 10.1038/s41589-021-00802-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.78 Å)

Structure validation