7LPS

Crystal structure of DDB1-CRBN-ALV1 complex bound to Helios (IKZF2 ZF2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000781	cellular_component	chromosome, telomeric region
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0006281	biological_process	DNA repair
A	0006289	biological_process	nucleotide-excision repair
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0007056	biological_process	spindle assembly involved in female meiosis
A	0010498	biological_process	proteasomal protein catabolic process
A	0016055	biological_process	Wnt signaling pathway
A	0016567	biological_process	protein ubiquitination
A	0019076	biological_process	viral release from host cell
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
A	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
A	0032991	cellular_component	protein-containing complex
A	0034644	biological_process	cellular response to UV
A	0035234	biological_process	ectopic germ cell programmed cell death
A	0035861	cellular_component	site of double-strand break
A	0042752	biological_process	regulation of circadian rhythm
A	0043066	biological_process	negative regulation of apoptotic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0044725	biological_process	epigenetic programming in the zygotic pronuclei
A	0044877	molecular_function	protein-containing complex binding
A	0045070	biological_process	positive regulation of viral genome replication
A	0045722	biological_process	positive regulation of gluconeogenesis
A	0045732	biological_process	positive regulation of protein catabolic process
A	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
A	0048511	biological_process	rhythmic process
A	0051093	biological_process	negative regulation of developmental process
A	0051702	biological_process	biological process involved in interaction with symbiont
A	0070062	cellular_component	extracellular exosome
A	0070914	biological_process	UV-damage excision repair
A	0071987	molecular_function	WD40-repeat domain binding
A	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
A	0097602	molecular_function	cullin family protein binding
A	0160072	molecular_function	ubiquitin ligase complex scaffold activity
A	1901990	biological_process	regulation of mitotic cell cycle phase transition
A	2000242	biological_process	negative regulation of reproductive process
D	0000781	cellular_component	chromosome, telomeric region
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0003684	molecular_function	damaged DNA binding
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0006281	biological_process	DNA repair
D	0006289	biological_process	nucleotide-excision repair
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006915	biological_process	apoptotic process
D	0006974	biological_process	DNA damage response
D	0007056	biological_process	spindle assembly involved in female meiosis
D	0010498	biological_process	proteasomal protein catabolic process
D	0016055	biological_process	Wnt signaling pathway
D	0016567	biological_process	protein ubiquitination
D	0019076	biological_process	viral release from host cell
D	0030674	molecular_function	protein-macromolecule adaptor activity
D	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
D	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
D	0032991	cellular_component	protein-containing complex
D	0034644	biological_process	cellular response to UV
D	0035234	biological_process	ectopic germ cell programmed cell death
D	0035861	cellular_component	site of double-strand break
D	0042752	biological_process	regulation of circadian rhythm
D	0043066	biological_process	negative regulation of apoptotic process
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0044725	biological_process	epigenetic programming in the zygotic pronuclei
D	0044877	molecular_function	protein-containing complex binding
D	0045070	biological_process	positive regulation of viral genome replication
D	0045722	biological_process	positive regulation of gluconeogenesis
D	0045732	biological_process	positive regulation of protein catabolic process
D	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
D	0048511	biological_process	rhythmic process
D	0051093	biological_process	negative regulation of developmental process
D	0051702	biological_process	biological process involved in interaction with symbiont
D	0070062	cellular_component	extracellular exosome
D	0070914	biological_process	UV-damage excision repair
D	0071987	molecular_function	WD40-repeat domain binding
D	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
D	0097602	molecular_function	cullin family protein binding
D	0160072	molecular_function	ubiquitin ligase complex scaffold activity
D	1901990	biological_process	regulation of mitotic cell cycle phase transition
D	2000242	biological_process	negative regulation of reproductive process
G	0000781	cellular_component	chromosome, telomeric region
G	0003676	molecular_function	nucleic acid binding
G	0003677	molecular_function	DNA binding
G	0003684	molecular_function	damaged DNA binding
G	0005515	molecular_function	protein binding
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0006281	biological_process	DNA repair
G	0006289	biological_process	nucleotide-excision repair
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006915	biological_process	apoptotic process
G	0006974	biological_process	DNA damage response
G	0007056	biological_process	spindle assembly involved in female meiosis
G	0010498	biological_process	proteasomal protein catabolic process
G	0016055	biological_process	Wnt signaling pathway
G	0016567	biological_process	protein ubiquitination
G	0019076	biological_process	viral release from host cell
G	0030674	molecular_function	protein-macromolecule adaptor activity
G	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
G	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
G	0032991	cellular_component	protein-containing complex
G	0034644	biological_process	cellular response to UV
G	0035234	biological_process	ectopic germ cell programmed cell death
G	0035861	cellular_component	site of double-strand break
G	0042752	biological_process	regulation of circadian rhythm
G	0043066	biological_process	negative regulation of apoptotic process
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0044725	biological_process	epigenetic programming in the zygotic pronuclei
G	0044877	molecular_function	protein-containing complex binding
G	0045070	biological_process	positive regulation of viral genome replication
G	0045722	biological_process	positive regulation of gluconeogenesis
G	0045732	biological_process	positive regulation of protein catabolic process
G	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
G	0048511	biological_process	rhythmic process
G	0051093	biological_process	negative regulation of developmental process
G	0051702	biological_process	biological process involved in interaction with symbiont
G	0070062	cellular_component	extracellular exosome
G	0070914	biological_process	UV-damage excision repair
G	0071987	molecular_function	WD40-repeat domain binding
G	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
G	0097602	molecular_function	cullin family protein binding
G	0160072	molecular_function	ubiquitin ligase complex scaffold activity
G	1901990	biological_process	regulation of mitotic cell cycle phase transition
G	2000242	biological_process	negative regulation of reproductive process
J	0000781	cellular_component	chromosome, telomeric region
J	0003676	molecular_function	nucleic acid binding
J	0003677	molecular_function	DNA binding
J	0003684	molecular_function	damaged DNA binding
J	0005515	molecular_function	protein binding
J	0005615	cellular_component	extracellular space
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005730	cellular_component	nucleolus
J	0005737	cellular_component	cytoplasm
J	0006281	biological_process	DNA repair
J	0006289	biological_process	nucleotide-excision repair
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0006915	biological_process	apoptotic process
J	0006974	biological_process	DNA damage response
J	0007056	biological_process	spindle assembly involved in female meiosis
J	0010498	biological_process	proteasomal protein catabolic process
J	0016055	biological_process	Wnt signaling pathway
J	0016567	biological_process	protein ubiquitination
J	0019076	biological_process	viral release from host cell
J	0030674	molecular_function	protein-macromolecule adaptor activity
J	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
J	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
J	0032991	cellular_component	protein-containing complex
J	0034644	biological_process	cellular response to UV
J	0035234	biological_process	ectopic germ cell programmed cell death
J	0035861	cellular_component	site of double-strand break
J	0042752	biological_process	regulation of circadian rhythm
J	0043066	biological_process	negative regulation of apoptotic process
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0044725	biological_process	epigenetic programming in the zygotic pronuclei
J	0044877	molecular_function	protein-containing complex binding
J	0045070	biological_process	positive regulation of viral genome replication
J	0045722	biological_process	positive regulation of gluconeogenesis
J	0045732	biological_process	positive regulation of protein catabolic process
J	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
J	0048511	biological_process	rhythmic process
J	0051093	biological_process	negative regulation of developmental process
J	0051702	biological_process	biological process involved in interaction with symbiont
J	0070062	cellular_component	extracellular exosome
J	0070914	biological_process	UV-damage excision repair
J	0071987	molecular_function	WD40-repeat domain binding
J	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
J	0097602	molecular_function	cullin family protein binding
J	0160072	molecular_function	ubiquitin ligase complex scaffold activity
J	1901990	biological_process	regulation of mitotic cell cycle phase transition
J	2000242	biological_process	negative regulation of reproductive process

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cnq..CgasFtqkgnllrHikl..H

Chain	Residue	Details
C	CYS142-HIS162

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	ZN_FING: C2H2-type 2 => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
C	PHE140-HIS162
F	PHE140-HIS162
I	PHE140-HIS162
L	PHE140-HIS162
H	HIS378
H	TRP380
H	TRP386
H	CYS391
H	CYS394
K	CYS323
K	CYS326
K	HIS378
K	TRP380
K	TRP386
K	CYS391
K	CYS394
B	TRP386
B	CYS391
B	CYS394
E	CYS323
E	CYS326
E	HIS378
E	TRP380
E	TRP386
E	CYS391
E	CYS394
H	CYS323
H	CYS326

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site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
D	LYS1067
G	LYS1067
J	LYS1067
A	LYS1067

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9ESW0

Chain	Residue	Details
D	THR1125
G	THR1125
J	THR1125
A	THR1125

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site_id	SWS_FT_FI4
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
D	LYS1121
G	LYS1121
J	LYS1121
A	LYS1121

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