7NYC
 
 | | cryoEM structure of 3C9-sMAC | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Menny, A, Couves, E.C, Bubeck, D. | | 登録日 | 2021-03-22 | | 公開日 | 2021-10-06 | | 最終更新日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural basis of soluble membrane attack complex packaging for clearance.
Nat Commun, 12, 2021
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7NYD
 | | cryoEM structure of 2C9-sMAC | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Menny, A, Couves, E.C, Bubeck, D. | | 登録日 | 2021-03-22 | | 公開日 | 2021-10-06 | | 最終更新日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis of soluble membrane attack complex packaging for clearance.
Nat Commun, 12, 2021
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5JPM
 | | Structure of the complex of human complement C4 with MASP-2 rebuilt using iMDFF | | 分子名称: | Complement C4-A, Mannan-binding lectin serine protease 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Croll, T.I, Andersen, G.R. | | 登録日 | 2016-05-03 | | 公開日 | 2016-08-10 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.75 Å) | | 主引用文献 | Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4.
Acta Crystallogr D Struct Biol, 72, 2016
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3KLS
 | | Structure of complement C5 in complex with SSL7 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ... | | 著者 | Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R. | | 登録日 | 2009-11-09 | | 公開日 | 2009-11-24 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
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3KM9
 | | Structure of complement C5 in complex with the C-terminal beta-grasp domain of SSL7 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ... | | 著者 | Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R. | | 登録日 | 2009-11-10 | | 公開日 | 2009-12-01 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | | 主引用文献 | Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
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3PVM
 | | Structure of Complement C5 in Complex with CVF | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, Complement C5 | | 著者 | Laursen, N.S, Andersen, K.R, Braren, I, Sottrup-Jensen, L, Spillner, E, Andersen, G.R. | | 登録日 | 2010-12-07 | | 公開日 | 2011-01-19 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | | 主引用文献 | Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Embo J., 30, 2011
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5JPN
 | | Structure of human complement C4 rebuilt using iMDFF | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C4-A, ... | | 著者 | Croll, T.I, Andersen, G.R. | | 登録日 | 2016-05-03 | | 公開日 | 2016-08-10 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4.
Acta Crystallogr D Struct Biol, 72, 2016
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3PRX
 | | Structure of Complement C5 in Complex with CVF and SSL7 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, ... | | 著者 | Laursen, N.S, Andersen, G.R, Sottrup-Jensen, L, Andersen, K.R, Spillner, E, Braren, I. | | 登録日 | 2010-11-30 | | 公開日 | 2011-01-19 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | | 主引用文献 | Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Embo J., 30, 2011
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8HK5
 | | C5aR1-Gi-C5a protein complex | | 分子名称: | C5a anaphylatoxin chemotactic receptor 1, Complement C5, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. | | 登録日 | 2022-11-24 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins.
Nat.Chem.Biol., 19, 2023
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8HK2
 | | C3aR-Gi-C3a protein complex | | 分子名称: | C3a anaphylatoxin, C3a anaphylatoxin chemotactic receptor, CHOLESTEROL, ... | | 著者 | Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. | | 登録日 | 2022-11-24 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins.
Nat.Chem.Biol., 19, 2023
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8COE
 | | complement C5 in complex with the LCP0195 nanobody | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, Complement C5 beta chain, ... | | 著者 | Andersen, G.R, Pedersen, D.V. | | 登録日 | 2023-02-28 | | 公開日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | | 主引用文献 | Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration.
Mol.Immunol., 165, 2023
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8CEM
 | | Structure of bovine native C3, re-refinement | | 分子名称: | Complement C3 alpha chain, Complement C3 beta chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Andersen, G.R, Fredslund, F. | | 登録日 | 2023-02-02 | | 公開日 | 2023-04-05 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The structure of bovine complement component 3 reveals the basis for thioester function.
J Mol Biol, 361, 2006
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8CML
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8IA2
 | | Structure of C5a bound human C5aR1 in complex with Go (Composite map) | | 分子名称: | Antibody fragment - ScFv16, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... | | 著者 | Yadav, M.K, Yadav, R, Maharana, J, Banerjee, R, Shukla, A.K, Gati, C. | | 登録日 | 2023-02-07 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors.
Cell, 186, 2023
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8I9L
 | | Structure of C3a-C3aR-Go complex (Composite map) | | 分子名称: | Antibody fragment - ScFv16, C3a anaphylatoxin, C3a anaphylatoxin chemotactic receptor, ... | | 著者 | Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C. | | 登録日 | 2023-02-07 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors.
Cell, 186, 2023
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8JZZ
 | | Structure of human C5a-desArg bound human C5aR1 in complex with Go | | 分子名称: | Antibody fragment ScFv16, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... | | 著者 | Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C. | | 登録日 | 2023-07-06 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | | 主引用文献 | Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors.
Cell, 186, 2023
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5HCD
 | | Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus microplus RaCI2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, Complement C5, ... | | 著者 | Jore, M.M, Johnson, S, Lea, S.M. | | 登録日 | 2016-01-04 | | 公開日 | 2016-03-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
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5I5K
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5HCC
 | | Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Dermacentor andersoni RaCI3. | | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Jore, M.M, Johnson, S, Lea, S.M. | | 登録日 | 2016-01-04 | | 公開日 | 2016-03-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
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8OQ3
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5HCE
 | | Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus appendiculatus RaCI1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, Complement C5, ... | | 著者 | Jore, M.M, Johnson, S, Lea, S.M. | | 登録日 | 2016-01-04 | | 公開日 | 2016-03-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | | 主引用文献 | Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
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7AD6
 | | Crystal structure of human complement C5 in complex with the K92 bovine knob domain peptide. | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CYSTEINE, ... | | 著者 | Macpherson, A, van den Elsen, J.M.H, Schulze, M.E, Birtley, J.R. | | 登録日 | 2020-09-14 | | 公開日 | 2021-03-10 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | The allosteric modulation of Complement C5 by knob domain peptides.
Elife, 10, 2021
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7AD7
 | | Crystal structure of human complement C5 in complex with the K8 bovine knob domain peptide. | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Macpherson, A, van den Elsen, J.M.H, Schulze, M.E, Birtley, J.R. | | 登録日 | 2020-09-14 | | 公開日 | 2021-03-10 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The allosteric modulation of Complement C5 by knob domain peptides.
Elife, 10, 2021
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7ZGJ
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8AYH
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