PDB: 285 件ウェブページステータス検索Chemie searchBIRD

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6OIU	X-ray crystal structure of the ectodomain of the Toxoplasma gondii ME49 Aminopeptidase N (TGME49_224350) 分子名称: Aminopeptidase N, GLYCEROL, ZINC ION 著者 McGowan, S, Drinkwater, N. 登録日 2019-04-09 公開日 2020-09-30 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 X-ray crystal structure and specificity of the Toxoplasma gondii ME49 TgAPN2. Biochem.J., 477, 2020
1Z1W	Crystal structures of the tricorn interacting facor F3 from Thermoplasma acidophilum, a zinc aminopeptidase in three different conformations 分子名称: SULFATE ION, Tricorn protease interacting factor F3, ZINC ION 著者 Kyrieleis, O.J.P, Goettig, P, Kiefersauer, R, Huber, R, Brandstetter, H. 登録日 2005-03-07 公開日 2005-05-31 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal Structures of the Tricorn Interacting Factor F3 from Thermoplasma acidophilum, a Zinc Aminopeptidase in Three Different Conformations J.MOL.BIOL., 394, 2005
2HPT	Crystal Structure of E. coli PepN (Aminopeptidase N)in complex with Bestatin 分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, Aminopeptidase N, GLYCEROL, ... 著者 Addlagatta, A, Matthews, B.W, Gay, L. 登録日 2006-07-17 公開日 2006-08-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site. Proc.Natl.Acad.Sci.Usa, 103, 2006
2HPO	Structure of Aminopeptidase N from E. coli Suggests a Compartmentalized, Gated Active Site 分子名称: Aminopeptidase N, GLYCEROL, ZINC ION 著者 Addlagatta, A, Matthews, B.W, Gay, L. 登録日 2006-07-17 公開日 2006-08-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site. Proc.Natl.Acad.Sci.Usa, 103, 2006
2DQM	Crystal Structure of Aminopeptidase N complexed with bestatin 分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, Aminopeptidase N, SULFATE ION, ... 著者 Onohara, Y, Nakajima, Y, Ito, K, Yoshimoto, T. 登録日 2006-05-29 公開日 2006-08-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli: Crystal structure and conformational change of the methionine 260 residue involved in substrate recognition J.Biol.Chem., 281, 2006
7NUP	Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxamic and sulfonyl ligand 分子名称: (3~{S})-4-(4-hydroxyphenyl)-~{N}-oxidanyl-3-[5-[[(5-phenylthiophen-2-yl)sulfonylamino]methyl]-1,2,3-triazol-1-yl]butanamide, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Mpakali, A, Giastas, P, Stratikos, E. 登録日 2021-03-12 公開日 2022-06-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Endoplasmic reticulum aminopeptidase 2 complexed with a mixed hydroxamic and sulfonyl ligand To Be Published
7NSK	Endoplasmic reticulum aminopeptidase 2 complexed with a hydroxamic ligand 分子名称: (2~{S})-3-(4-hydroxyphenyl)-~{N}-oxidanyl-2-[4-[[(5-pyridin-2-ylthiophen-2-yl)sulfonylamino]methyl]-1,2,3-triazol-1-yl]propanamide, 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ... 著者 Mpakali, A, Giastas, P, Stratikos, E. 登録日 2021-03-08 公開日 2022-06-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Endoplasmic reticulum aminopeptidase 2 in complex with a phosphinic ligand To Be Published
7P7P	Crystal structure of ERAP2 aminopeptidase in complex with phosphinic pseudotripeptide((1R)-1-Amino-3-phenylpropyl){(2S)-3-[((2S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino]-2-{[3-(2-hydroxyphenyl)-isoxazol-5-yl]methyl}-3-oxopropyl}phosphinic acid 分子名称: 1,2-ETHANEDIOL, 1,3-PROPANDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... 著者 Giastas, P, Stratikos, E, Mpakali, A. 登録日 2021-07-20 公開日 2022-01-26 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Inhibitor-Dependent Usage of the S1' Specificity Pocket of ER Aminopeptidase 2. Acs Med.Chem.Lett., 13, 2022
1H19	STRUCTURE OF [E271Q]LEUKOTRIENE A4 HYDROLASE 分子名称: ACETIC ACID, IMIDAZOLE, LEUKOTRIENE A-4 HYDROLASE, ... 著者 Rudberg, P.C, Tholander, F, Thunnissen, M.M.G.M, Haeggstrom, J.Z. 登録日 2002-07-04 公開日 2002-08-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Leukotriene A4 Hydrolase/Aminopeptidase, Glutamate 271 is a Catalyticresidue with Specific Roles in Two Distinct Enzyme Mechanisms J.Biol.Chem., 277, 2002
1GW6	STRUCTURE OF LEUKOTRIENE A4 HYDROLASE D375N MUTANT 分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ACETATE ION, IMIDAZOLE, ... 著者 Rudberg, P.C, Tholander, F, Thunnissen, M.M.G.M, Samuelsson, B, Haeggstrom, J.Z. 登録日 2002-03-07 公開日 2003-03-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Leukotriene A4 Hydrolase: Selective Abrogation of Leukotriene B4 Formation by Mutation of Aspartic Acid 375 Proc.Natl.Acad.Sci.USA, 99, 2002
1HS6	STRUCTURE OF LEUKOTRIENE A4 HYDROLASE COMPLEXED WITH BESTATIN. 分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ACETATE ION, IMIDAZOLE, ... 著者 Thunnissen, M.M.G.M, Nordlund, P.N, Haeggstrom, J.Z. 登録日 2000-12-24 公開日 2001-06-24 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation. Nat.Struct.Biol., 8, 2001
4FYS	Human aminopeptidase N (CD13) in complex with angiotensin IV 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... 著者 Wong, A.H, Rini, J.M. 登録日 2012-07-05 公開日 2012-09-05 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing. J.Biol.Chem., 287, 2012
4FYT	Human aminopeptidase N (CD13) in complex with amastatin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AMASTATIN, ... 著者 Wong, A.H, Rini, J.M. 登録日 2012-07-05 公開日 2012-09-05 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing. J.Biol.Chem., 287, 2012
4GAA	Structure of Leukotriene A4 hydrolase from Xenopus laevis complexed with inhibitor bestatin 分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, MGC78867 protein, ZINC ION 著者 Stsiapanava, A, Kumar, R.B, Haeggstrom, J.Z, Rinaldo-Matthis, A. 登録日 2012-07-25 公開日 2013-06-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Product formation controlled by substrate dynamics in leukotriene A4 hydrolase. Biochim.Biophys.Acta, 1844, 2014
4FYR	Human aminopeptidase N (CD13) in complex with bestatin 分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Wong, A.H, Rini, J.M. 登録日 2012-07-05 公開日 2012-09-05 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing. J.Biol.Chem., 287, 2012
7AV1	LTA4 hydrolase in complex with fragment2 分子名称: 2-[5-(4-methoxyphenyl)-1,2,3,4-tetrazol-2-yl]ethanamine, ACETATE ION, IMIDAZOLE, ... 著者 Srinivas, H. 登録日 2020-11-03 公開日 2021-02-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase. J.Med.Chem., 64, 2021
7AUZ	LTA4 hydrolase in complex with compound LYS006 分子名称: (3~{S})-3-azanyl-4-[5-[4-(5-chloranyl-3-fluoranyl-pyridin-2-yl)oxyphenyl]-1,2,3,4-tetrazol-2-yl]butanoic acid, ACETATE ION, IMIDAZOLE, ... 著者 Srinivas, H. 登録日 2020-11-03 公開日 2021-02-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase. J.Med.Chem., 64, 2021
7AV0	LTA4 hydrolase in complex with compound R(13) 分子名称: (3~{R})-3-azanyl-4-[5-[4-(4-chloranylphenoxy)phenyl]-1,2,3,4-tetrazol-2-yl]butanoic acid, ACETATE ION, IMIDAZOLE, ... 著者 Srinivas, H. 登録日 2020-11-03 公開日 2021-02-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase. J.Med.Chem., 64, 2021
7AV2	LTA4 hydrolase in complex with fragment1 分子名称: (4-phenoxyphenyl)methanol, ACETATE ION, IMIDAZOLE, ... 著者 Srinivas, H. 登録日 2020-11-03 公開日 2021-02-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase. J.Med.Chem., 64, 2021
2VJ8	Complex of human leukotriene A4 hydrolase with a hydroxamic acid inhibitor 分子名称: 6-[{(2S)-2-AMINO-3-[4-(BENZYLOXY)PHENYL]PROPYL}(HYDROXY)AMINO]-6-OXOHEXANOIC ACID), ACETATE ION, IMIDAZOLE, ... 著者 Thunnissen, M.M.G.M, Andersson, B, Wong, C.-H, Samuelsson, B, Haeggstrom, J.Z. 登録日 2007-12-07 公開日 2008-01-15 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structures of Leukotriene A4 Hydrolase in Complex with Captopril and Two Competitive Tight-Binding Inhibitors Faseb J., 16, 2002
2XQ0	Structure of yeast LTA4 hydrolase in complex with Bestatin 分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, CHLORIDE ION, LEUKOTRIENE A-4 HYDROLASE, ... 著者 Helgstrand, C, Hasan, M, Usyal, H, Haeggstrom, J.Z, Thunnissen, M.M.G.M. 登録日 2010-08-31 公開日 2010-12-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.955 Å) 主引用文献 A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding. J.Mol.Biol., 406, 2011
2XPY	Structure of Native Leukotriene A4 Hydrolase from Saccharomyces cerevisiae 分子名称: GLUTATHIONE, GLYCEROL, LEUKOTRIENE A-4 HYDROLASE, ... 著者 Helgstrand, C, Hasan, M, Usyal, H, Haeggstrom, J.Z, Thunnissen, M.M.G.M. 登録日 2010-08-31 公開日 2010-12-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.73 Å) 主引用文献 A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding. J.Mol.Biol., 406, 2011
2XPZ	Structure of native yeast LTA4 hydrolase 分子名称: (R,R)-2,3-BUTANEDIOL, LEUKOTRIENE A-4 HYDROLASE, POLYETHYLENE GLYCOL (N=34), ... 著者 Helgstrand, C, Hasan, M, Usyal, H, Haeggstrom, J.Z, Thunnissen, M.M.G.M. 登録日 2010-08-31 公開日 2010-12-29 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding. J.Mol.Biol., 406, 2011
3Q7J	Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development 分子名称: L-phenylalanyl-N6-[(benzyloxy)carbonyl]-N1-hydroxy-L-lysinamide, Tricorn protease-interacting factor F3, ZINC ION 著者 Su, J, Wang, Q, Feng, J, Zhang, C, Zhu, D, We, T, Xu, W, Gu, L. 登録日 2011-01-05 公開日 2011-07-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development Bioorg.Med.Chem., 19, 2011
3QNF	Crystal structure of the open state of human endoplasmic reticulum aminopeptidase 1 ERAP1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Endoplasmic reticulum aminopeptidase 1, ZINC ION, ... 著者 Vollmar, M, Kochan, G, Krojer, T, Harvey, D, Chaikuad, A, Allerston, C, Muniz, J.R.C, Raynor, J, Ugochukwu, E, Berridge, G, Wordsworth, B.P, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Kavanagh, K, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2011-02-08 公開日 2011-02-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming. Proc.Natl.Acad.Sci.USA, 108, 2011

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