7P7P

Crystal structure of ERAP2 aminopeptidase in complex with phosphinic pseudotripeptide((1R)-1-Amino-3-phenylpropyl){(2S)-3-[((2S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino]-2-{[3-(2-hydroxyphenyl)-isoxazol-5-yl]methyl}-3-oxopropyl}phosphinic acid

Summary for 7P7P

Entry DOI	10.2210/pdb7p7p/pdb
Related	5AB0 5AB2 5CU5
Descriptor	Endoplasmic reticulum aminopeptidase 2, TRIETHYLENE GLYCOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (16 entities in total)
Functional Keywords	erap2, transition state analogues, antigen presentation, hydrolase, phosphinic pseudotripeptides, aminopeptidase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	230750.79
Authors	Giastas, P.,Stratikos, E.,Mpakali, A. (deposition date: 2021-07-20, release date: 2022-01-26, Last modification date: 2024-01-31)
Primary citation	Mpakali, A.,Georgiadis, D.,Stratikos, E.,Giastas, P. Inhibitor-Dependent Usage of the S1' Specificity Pocket of ER Aminopeptidase 2. Acs Med.Chem.Lett., 13:218-224, 2022 Cited by PubMed: 35178178 DOI: 10.1021/acsmedchemlett.1c00582 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation