PDB: 145 件ウェブページステータス検索Chemie searchBIRD

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5LYL	Crystal structure of 1 in complex with tafCPB 分子名称: (2~{S})-2-[[(2~{S})-1-(1-adamantylamino)-3-cyclohexyl-1-oxidanylidene-propan-2-yl]sulfamoylamino]-6-azanyl-hexanoic acid, Carboxypeptidase B, ZINC ION 著者 Schreuder, H, Liesum, A, Loenze, P. 登録日 2016-09-28 公開日 2016-10-26 最終更新日 2016-12-21 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). J. Med. Chem., 59, 2016
5LYI	Crystal structure of 1 in complex with tafCPB 分子名称: (2~{S})-6-azanyl-2-[[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(1~{R},2~{S},4~{R})-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]hexanoic acid, Carboxypeptidase B, ZINC ION 著者 Schreuder, H, Liesum, A, Loenze, P. 登録日 2016-09-28 公開日 2016-10-26 最終更新日 2016-12-21 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). J. Med. Chem., 59, 2016
5LRG	Crystal structure of the porcine carboxypeptidase B - Anabaenopeptin B complex 分子名称: Anabaenopeptin B, Carboxypeptidase B, ZINC ION 著者 Schreuder, H, Liesum, A, Loenze, P. 登録日 2016-08-19 公開日 2016-09-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). Sci Rep, 6, 2016
5LRK	Crystal structure of the porcine carboxypeptidase B - Anabaenopeptin F complex 分子名称: Anabaenopeptin F, Carboxypeptidase B, ZINC ION 著者 Schreuder, H, Liesum, A, Loenze, P. 登録日 2016-08-19 公開日 2016-09-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). Sci Rep, 6, 2016
5LRJ	Crystal structure of the porcine carboxypeptidase B - Anabaenopeptin C complex 分子名称: Anabaenopeptin C, Carboxypeptidase B, ZINC ION 著者 Schreuder, H, Liesum, A, Loenze, P. 登録日 2016-08-19 公開日 2016-09-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). Sci Rep, 6, 2016
5HVH	Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with two Inhibitory Nanobodies 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Carboxypeptidase B2, ... 著者 Zhou, X, Weeks, S.D, Strelkov, S.V, Declerck, P.J. 登録日 2016-01-28 公開日 2016-06-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity. J.Thromb.Haemost., 14, 2016
5HVG	Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-a204) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... 著者 Zhou, X, Weeks, S.D, Strelkov, S.V, Declerck, P.J. 登録日 2016-01-28 公開日 2016-06-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity. J.Thromb.Haemost., 14, 2016
5HVF	Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-i83) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, Carboxypeptidase B2, ... 著者 Zhou, X, Weeks, S.D, Strelkov, S.V, Declerck, P.J. 登録日 2016-01-28 公開日 2016-06-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity. J.Thromb.Haemost., 14, 2016
4UEZ	Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Phe-Y(PO2CH2)-Phe-OH 分子名称: (2S)-3-[(R)-{(1R)-1-[(N-acetyl-L-leucyl)amino]-2-phenylethyl}(hydroxy)phosphoryl]-2-benzylpropanoic acid, HUMAN CARBOXYPEPTIDASE A1, ZINC ION 著者 Gallego, P, Covaleda, G, Costenaro, L, Devel, L, Dive, V, Aviles, F.X, Reverter, D. 登録日 2014-12-22 公開日 2016-01-20 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors To be Published
4UEE	Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Ala-Y(PO2CH2)-homoPhe-OH 分子名称: (2S)-2-{[(R)-{(1R)-1-[(N-acetyl-L-leucyl)amino]ethyl}(hydroxy)phosphoryl]methyl}-4-phenylbutanoic acid, CARBOXYPEPTIDASE A1, ZINC ION 著者 Gallego, P, Covaleda, G, Costenaro, L, Devel, L, Dive, V, Aviles, F.X, Reverter, D. 登録日 2014-12-17 公開日 2016-01-20 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors To be Published
4Z65	Carboxypeptidase B with Sulphamoil Arginine 分子名称: Carboxypeptidase B, N~2~-sulfamoyl-L-arginine, ZINC ION 著者 Timofeev, V.I, Akparov, V.K, Kuranova, I.P. 登録日 2015-04-03 公開日 2015-10-14 最終更新日 2015-10-28 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Structure of the complex of carboxypeptidase B and N-sulfamoyl-L-arginine. Acta Crystallogr.,Sect.F, 71, 2015
4UIB	Crystal structure of 3p in complex with tafCPB 分子名称: (2S)-6-AMINO-2-[[(1R)-1-(CYCLOHEXYLMETHYL)-2-OXO-2-[[(2S)-1,7,7-TRIMETHYLNORBORNAN-2-YL]AMINO]ETHYL]ARBAMOYLAMINO]HEXANOIC ACID, ACETATE ION, CARBOXYPEPTIDASE B, ... 著者 Halland, N, Broenstrup, M, Czech, J, Czechtizky, W, Evers, A, Follmann, M, Kohlmann, M, Schiell, M, Kurz, M, Schreuder, H.A, Kallus, C. 登録日 2015-03-27 公開日 2015-06-03 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (Tafia) from Natural Product Anabaenopeptin. J.Med.Chem., 58, 2015
4UIA	Crystal structure of 3a in complex with tafCPB 分子名称: (2S)-6-azanyl-2-[[(2R)-3-cyclohexyl-1-(3-methylbutylamino)-1-oxidanylidene-propan-2-yl]carbamoylamino]hexanoic acid, CARBOXYPEPTIDASE B, ZINC ION 著者 Halland, N, Broenstrup, M, Czech, J, Czechtizky, W, Evers, A, Follmann, M, Kohlmann, M, Schiell, M, Kurz, M, Schreuder, H.A, Kallus, C. 登録日 2015-03-27 公開日 2015-06-03 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (Tafia) from Natural Product Anabaenopeptin. J.Med.Chem., 58, 2015
4OKO	Crystal structure of Francisella tularensis REP34 (Rapid Encystment Phenotype Protein 34 KDa) 分子名称: ACETATE ION, Rapid Encystment Phenotype Protein 34 KDa, ZINC ION 著者 Feld, G.K, Segelke, B.W, Corzett, M.H, Hunter, M.S, Frank, M, Rasley, A. 登録日 2014-01-22 公開日 2014-09-24 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.053 Å) 主引用文献 Structure and Function of REP34 Implicates Carboxypeptidase Activity in Francisella tularensis Host Cell Invasion. J.Biol.Chem., 289, 2014
4P10	pro-carboxypeptidase U In Complex With 5-(3-aminopropyl)-1-propyl-6,7-dihydro-4H-benzimidazole-5-carboxylic acid 分子名称: (5R)-5-(3-aminopropyl)-1-propyl-4,5,6,7-tetrahydro-1H-benzimidazole-5-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Carboxypeptidase B2, ... 著者 Hallberg, K, Sjogren, T. 登録日 2014-02-21 公開日 2014-08-13 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Design and synthesis of conformationally restricted inhibitors of active thrombin activatable fibrinolysis inhibitor (TAFIa). Bioorg.Med.Chem., 22, 2014
4IHM	G215S, A251G, T257A, D260G, T262D mutant of carboxypeptidase T from Thermoactinomyces vulgaris 分子名称: CALCIUM ION, Carboxypeptidase T, GLYCEROL, ... 著者 Timofeev, V.I, Kuznetsov, S.A, Akparov, V.K, Kuranova, I.P. 登録日 2012-12-19 公開日 2013-12-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 G215S, A251G, T257A, D260G, T262D mutant of carboxypeptidase T from Thermoactinomyces vulgaris To be published
4IK2	G215S, A251G, T257A, D260G, T262D mutant of carboxypeptidase T from Thermoactinomyces vulgaris with N-BOC-L-Leu 分子名称: CALCIUM ION, Carboxypeptidase T, N-(tert-butoxycarbonyl)-L-leucine, ... 著者 Timofeev, V.I, Kuznetsov, S.A, Akparov, V.K, Kuranova, I.P. 登録日 2012-12-25 公開日 2013-12-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 G215S, A251G, T257A, D260G, T262D mutant of carboxypeptidase T from Thermoactinomyces vulgaris with N-BOC-L-Leu To be published
4IAV	G215S, A251G, T257A, D260G, T262D mutant of carboxypeptidase T from Thermoactinomyces vulgaris with N-Sulfamoyl-L-phenylalanine 分子名称: CALCIUM ION, Carboxypeptidase T, GLYCEROL, ... 著者 Timofeev, V.I, Kuznetsov, S.A, Akparov, V.K, Kuranova, I.P. 登録日 2012-12-07 公開日 2013-12-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 G215S, A251G, T257A, D260G, T262D mutant of carboxypeptidase T from Thermoactinomyces vulgaris with N-Sulfamoyl-L-phenylalanine TO BE PUBLISHED
3WC6	Carboxypeptidase B in complex with 2nd zinc 分子名称: ACETATE ION, Carboxypeptidase B, ZINC ION 著者 Yoshimoto, N, Itoh, T, Inaba, Y, Yamamoto, K. 登録日 2013-05-24 公開日 2013-10-02 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme. J.Med.Chem., 56, 2013
3WC5	Carboxypeptidase B in complex with DD9 分子名称: (2R)-7-amino-2-(selanylmethyl)heptanoic acid, CACODYLATE ION, Carboxypeptidase B, ... 著者 Yoshimoto, N, Itoh, T, Inaba, Y, Yamamoto, K. 登録日 2013-05-24 公開日 2013-10-02 最終更新日 2022-08-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme. J.Med.Chem., 56, 2013
3WC7	Carboxypeptidase B in complex with EF6265 分子名称: (2S)-7-amino-2-{[(R)-hydroxy{(1R)-2-methyl-1-[(3-phenylpropanoyl)amino]propyl}phosphoryl]methyl}heptanoic acid, Carboxypeptidase B, ZINC ION 著者 Yoshimoto, N, Itoh, T, Inaba, Y, Yamamoto, K. 登録日 2013-05-24 公開日 2013-10-02 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme. J.Med.Chem., 56, 2013
3WAB	Carboxypeptidase B in complex with DD2 分子名称: (2R)-7-amino-2-(sulfanylmethyl)heptanoic acid, CACODYLATE ION, Carboxypeptidase B, ... 著者 Yoshimoto, N, Itoh, T, Inaba, Y, Yamamoto, K. 登録日 2013-05-01 公開日 2013-10-02 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.154 Å) 主引用文献 Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme. J.Med.Chem., 56, 2013
4GM5	Carboxypeptidase T with Sulphamoil Arginine 分子名称: CALCIUM ION, Carboxypeptidase T, GLYCEROL, ... 著者 Kuznetsov, S.A, Timofeev, V.I, Akparov, V.K, Kuranova, I.P. 登録日 2012-08-15 公開日 2013-08-21 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Carboxypeptidase T with Sulphamoil Arginine To be Published
4BD9	Structure of the complex between SmCI and human carboxypeptidase A4 分子名称: CARBOXYPEPTIDASE A4, CARBOXYPEPTIDASE INHIBITOR SMCI, ZINC ION 著者 Alonso-del-Ribero, M, Reytor, M.L, Trejo, S.A, Chavez, M.A, Aviles, F.X, Reverter, D. 登録日 2012-10-05 公開日 2013-07-17 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A Noncanonical Mechanism of Carboxypeptidase Inhibition Revealed by the Crystal Structure of the Tri-Kunitz Smci in Complex with Human Cpa4. Structure, 21, 2013
4F8Z	Carboxypeptidase T with Boc-Leu 分子名称: CALCIUM ION, Carboxypeptidase T, GLYCEROL, ... 著者 Timofeev, V.I, Kuznetsov, S.A, Akparov, V.K, Kuranova, I.P. 登録日 2012-05-18 公開日 2013-05-22 最終更新日 2015-09-30 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Three-dimensional structure of carboxypeptidase T from Thermoactinomyces vulgaris in complex with N-BOC-L-leucine. Biochemistry Mosc., 78, 2013

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