5OM9
Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with a thiirane mechanism-based inhibitor
Replaces: 4UF4Summary for 5OM9
Entry DOI | 10.2210/pdb5om9/pdb |
Descriptor | Carboxypeptidase A1, (2~{R})-4-methyl-2-[(1~{S})-1-sulfanylethyl]pentanoic acid, ZINC ION, ... (4 entities in total) |
Functional Keywords | hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P15085 |
Total number of polymer chains | 2 |
Total formula weight | 94928.83 |
Authors | Gallego, P.,Granados, C.,Fernandez, D.,Pallares, I.,Covaleda, G.,Aviles, F.X.,Vendrell, J.,Reverter, D. (deposition date: 2017-07-28, release date: 2017-08-09, Last modification date: 2024-01-17) |
Primary citation | Testero, S.A.,Granados, C.,Fernandez, D.,Gallego, P.,Covaleda, G.,Reverter, D.,Vendrell, J.,Aviles, F.X.,Pallares, I.,Mobashery, S. Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library. ACS Med Chem Lett, 8:1122-1127, 2017 Cited by PubMed: 29057062DOI: 10.1021/acsmedchemlett.7b00346 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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