5LYI
Crystal structure of 1 in complex with tafCPB
Summary for 5LYI
Entry DOI | 10.2210/pdb5lyi/pdb |
Related | 5LYL |
Descriptor | Carboxypeptidase B, ZINC ION, (2~{S})-6-azanyl-2-[[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(1~{R},2~{S},4~{R})-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]hexanoic acid, ... (4 entities in total) |
Functional Keywords | tafinized carboxypeptidase b, hydrolase |
Biological source | Sus scrofa (Pig) |
Cellular location | Secreted : P09955 |
Total number of polymer chains | 1 |
Total formula weight | 35570.92 |
Authors | Schreuder, H.,Liesum, A.,Loenze, P. (deposition date: 2016-09-28, release date: 2016-10-26, Last modification date: 2016-12-21) |
Primary citation | Halland, N.,Czech, J.,Czechtizky, W.,Evers, A.,Follmann, M.,Kohlmann, M.,Schreuder, H.A.,Kallus, C. Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). J. Med. Chem., 59:9567-9573, 2016 Cited by PubMed: 27749053DOI: 10.1021/acs.jmedchem.6b01276 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.64 Å) |
Structure validation
Download full validation report