4UIA
Crystal structure of 3a in complex with tafCPB
Summary for 4UIA
Entry DOI | 10.2210/pdb4uia/pdb |
Related | 4UIB |
Descriptor | CARBOXYPEPTIDASE B, ZINC ION, (2S)-6-azanyl-2-[[(2R)-3-cyclohexyl-1-(3-methylbutylamino)-1-oxidanylidene-propan-2-yl]carbamoylamino]hexanoic acid, ... (4 entities in total) |
Functional Keywords | hydrolase, tafi, carboxypeptidase, thrombosis, fibrinolysis, drug discovery |
Biological source | SUS SCROFA (PIG) |
Cellular location | Secreted: P09955 |
Total number of polymer chains | 1 |
Total formula weight | 35468.76 |
Authors | Halland, N.,Broenstrup, M.,Czech, J.,Czechtizky, W.,Evers, A.,Follmann, M.,Kohlmann, M.,Schiell, M.,Kurz, M.,Schreuder, H.A.,Kallus, C. (deposition date: 2015-03-27, release date: 2015-06-03, Last modification date: 2015-08-26) |
Primary citation | Halland, N.,Bronstrup, M.,Czech, J.,Czechtizky, W.,Evers, A.,Follmann, M.,Kohlmann, M.,Schiell, M.,Kurz, M.,Schreuder, H.A.,Kallus, C. Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (Tafia) from Natural Product Anabaenopeptin. J.Med.Chem., 58:4839-, 2015 Cited by PubMed: 25990761DOI: 10.1021/JM501840B PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.18 Å) |
Structure validation
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