PDB: 142 件ウェブページステータス検索Chemie searchBIRD

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5TX2	Miniature TGF-beta2 3-mutant monomer 分子名称: Transforming growth factor beta-2 著者 Taylor, A.B, Kim, S.K, Hart, P.J, Hinck, A.P. 登録日 2016-11-15 公開日 2017-03-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling. J. Biol. Chem., 292, 2017
5UHM	Apo-Structure of Mature Growth Differentiation Factor 11 分子名称: Growth/differentiation factor 11 著者 Goebel, E, Thompson, T. 登録日 2017-01-11 公開日 2017-03-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for potency differences between GDF8 and GDF11. BMC Biol., 15, 2017
5MR9	Ligand-receptor complex. 分子名称: Neurturin 著者 Sandmark, J, Oster, L, Aagaard, A, Roth, R.G, Dahl, G. 登録日 2016-12-21 公開日 2018-01-17 最終更新日 2019-10-16 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure and biophysical characterisation of the human complex - a role for heparan sulfate To Be Published
2GYR	Crystal structure of human artemin 分子名称: Neurotrophic factor artemin, isoform 3 著者 Wang, X.Q. 登録日 2006-05-09 公開日 2006-06-27 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure, 14, 2006
2GYZ	Crystal structure of human artemin 分子名称: neurotrophic factor artemin isoform 3 著者 Wang, X.Q, Garcia, K.C. 登録日 2006-05-10 公開日 2006-06-27 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure, 14, 2006
5NMZ	human Neurturin (97-197) 分子名称: GLYCEROL, Neurturin 著者 Bigalke, J.M, Sandmark, J, Roth, R. 登録日 2017-04-07 公開日 2018-02-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling. J. Biol. Chem., 293, 2018
7RCO	Crystal structure of human TGF-beta-2 bound to 4A11.V2 Fab 分子名称: 4A11.V2 Fab Heavy Chain, 4A11.V2 Fab Light Chain, Transforming growth factor beta-2 著者 Yin, J, Lupardus, P.J, Sudhamsu, J. 登録日 2021-07-07 公開日 2021-09-29 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Dramatic activation of an antibody by a single amino acid change in framework. Sci Rep, 11, 2021
6OMO	Human BMP6 homodimer 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bone morphogenetic protein 6, ... 著者 Juo, Z.S, Seeherman, H. 登録日 2019-04-19 公開日 2019-05-08 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix. Sci Transl Med, 11, 2019
6OMN	Glycosylated BMP2 homodimer 分子名称: Bone morphogenetic protein 2, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Juo, Z.S, Seeherman, H. 登録日 2019-04-19 公開日 2019-05-08 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix. Sci Transl Med, 11, 2019
1KLA	SOLUTION STRUCTURE OF TGF-B1, NMR, MODELS 1-17 OF 33 STRUCTURES 分子名称: TRANSFORMING GROWTH FACTOR-BETA 1 著者 Hinck, A.P, Archer, S.J, Qian, S.W, Roberts, A.B, Sporn, M.B, Weatherbee, J.A, Tsang, M.L.-S, Lucas, R, Zhang, B.-L, Wenker, J, Torchia, D.A. 登録日 1996-01-16 公開日 1996-08-17 最終更新日 2017-11-29 実験手法 SOLUTION NMR 主引用文献 Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2. Biochemistry, 35, 1996
1KLC	SOLUTION STRUCTURE OF TGF-B1, NMR, MINIMIZED AVERAGE STRUCTURE 分子名称: TRANSFORMING GROWTH FACTOR-BETA 1 著者 Hinck, A.P, Archer, S.J, Qian, S.W, Roberts, A.B, Sporn, M.B, Weatherbee, J.A, Tsang, M.L.-S, Lucas, R, Zhang, B.-L, Wenker, J, Torchia, D.A. 登録日 1996-01-16 公開日 1996-08-17 最終更新日 2017-11-29 実験手法 SOLUTION NMR 主引用文献 Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2. Biochemistry, 35, 1996
1KLD	SOLUTION STRUCTURE OF TGF-B1, NMR, MODELS 18-33 OF 33 STRUCTURES 分子名称: TRANSFORMING GROWTH FACTOR-BETA 1 著者 Hinck, A.P, Archer, S.J, Qian, S.W, Roberts, A.B, Sporn, M.B, Weatherbee, J.A, Tsang, M.L.-S, Lucas, R, Zhang, B.-L, Wenker, J, Torchia, D.A. 登録日 1996-01-16 公開日 1996-08-17 最終更新日 2017-11-29 実験手法 SOLUTION NMR 主引用文献 Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2. Biochemistry, 35, 1996
1LXI	Refinement of BMP7 crystal structure 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, BONE MORPHOGENETIC PROTEIN 7 著者 Greenwald, J, Groppe, J, Kwiatkowski, W, Choe, S. 登録日 2002-06-05 公開日 2003-04-01 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The BMP7/ActRII Extracellular Domain Complex Provides New Insights into the Cooperative Nature of Receptor Assembly Mol.Cell, 11, 2003
1REU	Structure of the bone morphogenetic protein 2 mutant L51P 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, bone morphogenetic protein 2 著者 Keller, S, Nickel, J, Zhang, J.-L, Sebald, W, Mueller, T.D. 登録日 2003-11-07 公開日 2004-05-04 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Molecular recognition of BMP-2 and BMP receptor IA. Nat.Struct.Mol.Biol., 11, 2004
1TGK	HUMAN TRANSFORMING GROWTH FACTOR BETA 3, CRYSTALLIZED FROM PEG 4000 分子名称: TRANSFORMING GROWTH FACTOR BETA 3 著者 Mittl, P.R.E, Priestle, J.P, Gruetter, M.G. 登録日 1996-07-10 公開日 1997-03-12 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding. Protein Sci., 5, 1996
1TFG	AN UNUSUAL FEATURE REVEALED BY THE CRYSTAL STRUCTURE AT 2.2 ANGSTROMS RESOLUTION OF HUMAN TRANSFORMING GROWTH FACTOR-BETA2 分子名称: TRANSFORMING GROWTH FACTOR, BETA 2 著者 Gruetter, M, Schlunegger, M. 登録日 1992-11-17 公開日 1993-10-31 最終更新日 2019-08-14 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 An unusual feature revealed by the crystal structure at 2.2 A resolution of human transforming growth factor-beta 2. Nature, 358, 1992
1TGJ	HUMAN TRANSFORMING GROWTH FACTOR-BETA 3, CRYSTALLIZED FROM DIOXANE 分子名称: 1,4-DIETHYLENE DIOXIDE, TRANSFORMING GROWTH FACTOR-BETA 3 著者 Mittl, P.R.E, Priestle, J.P, Gruetter, M.G. 登録日 1996-07-09 公開日 1997-01-11 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding. Protein Sci., 5, 1996
5E4G	Crystal structure of human growth differentiation factor 11 (GDF-11) 分子名称: Growth/differentiation factor 11, TETRAETHYLENE GLYCOL 著者 Padyana, A.K, Vaidialingam, B, Hayes, D.B, Gupta, P, Franti, M, Farrow, N.A. 登録日 2015-10-06 公開日 2016-03-09 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal structure of human GDF11. Acta Crystallogr.,Sect.F, 72, 2016
5F3H	Structure of myostatin in complex with humanized RK35 antibody 分子名称: Growth/differentiation factor 8, humanized RK35 antibody heavy chain, humanized RK35 antibody light chain 著者 Parris, K.D, Mosyak, L. 登録日 2015-12-02 公開日 2016-09-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody. Mabs, 8, 2016
5F3B	Structure of myostatin in complex with chimeric RK35 antibody 分子名称: GLYCEROL, Growth/differentiation factor 8, RK35 Chimeric antibody heavy chain, ... 著者 Parris, K.D, Mosyak, L. 登録日 2015-12-02 公開日 2016-09-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody. Mabs, 8, 2016
5I05	Crystal structure of human BMP9 at 1.87 A resolution 分子名称: GLYCEROL, Growth/differentiation factor 2 著者 Saito, T, Bokhove, M, Jovine, L. 登録日 2016-02-03 公開日 2017-06-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1. Cell Rep, 19, 2017
6XM2	The structure of the 4A11.v7 antibody in complex with human TGFb2 分子名称: 4A11.v7 heavy chain Fab (VH-CH1) IgG1 humanized, 4A11.v7 kappa light chain Fab (VL-CL) humanized, Transforming growth factor beta-2 著者 Lupardus, P.J, Yin, J.P. 登録日 2020-06-29 公開日 2021-07-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 TGF beta 2 and TGF beta 3 isoforms drive fibrotic disease pathogenesis. Sci Transl Med, 13, 2021
6Y6O	Structure of mature activin A with small molecule 42 分子名称: (3~{R})-4-ethyl-3-methyl-3-propyl-1~{H}-1,4-benzodiazepine-2,5-dione, Inhibin beta A chain, SULFATE ION 著者 McLoughlin, J.D, Brear, P.B, Reinhardt, T, Spring, D.R, Hyvonen, M. 登録日 2020-02-26 公開日 2021-02-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion Chem Sci, 11, 2020
6Y6N	Structure of mature activin A with small molecule 2 分子名称: (3~{R})-3,4-dimethyl-3-propyl-1~{H}-1,4-benzodiazepine-2,5-dione, Inhibin beta A chain, SULFATE ION 著者 McLoughlin, J.D, Brear, P.B, Reinhardt, T, Spring, D.R, Hyvonen, M. 登録日 2020-02-26 公開日 2021-01-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion Chem Sci, 11, 2020
2QCQ	Crystal structure of Bone Morphogenetic Protein-3 (BMP-3) 分子名称: Bone morphogenetic protein 3 著者 Allendorph, G.P. 登録日 2007-06-19 公開日 2007-10-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 BMP-3 and BMP-6 Structures Illuminate the Nature of Binding Specificity with Receptors. Biochemistry, 46, 2007

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