1IK9
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![BU of 1ik9 by Molmil](/molmil-images/mine/1ik9) | CRYSTAL STRUCTURE OF A XRCC4-DNA LIGASE IV COMPLEX | 分子名称: | DNA LIGASE IV, DNA REPAIR PROTEIN XRCC4 | 著者 | Sibanda, B.L, Critchlow, S.E, Begun, J, Pei, X.Y, Jackson, S.P, Blundell, T.L, Pellegrini, L. | 登録日 | 2001-05-03 | 公開日 | 2001-11-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of an Xrcc4-DNA ligase IV complex. Nat.Struct.Biol., 8, 2001
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4GLW
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![BU of 4glw by Molmil](/molmil-images/mine/4glw) | DNA ligase A in complex with inhibitor | 分子名称: | 7-methoxy-6-methylpteridine-2,4-diamine, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase, ... | 著者 | Prade, L, Lange, R, Tidten-Luksch, N, Chambovey, A. | 登録日 | 2012-08-15 | 公開日 | 2012-10-10 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity. Bioorg.Med.Chem.Lett., 22, 2012
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6WH1
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![BU of 6wh1 by Molmil](/molmil-images/mine/6wh1) | Structure of the complex of human DNA ligase III-alpha and XRCC1 BRCT domains | 分子名称: | DNA ligase 3 alpha, X-ray repair cross complementing protein 1 variant | 著者 | Pourfarjam, Y, Ellenberger, T, Tainer, J.A, Tomkinson, A.E, Kim, I.K. | 登録日 | 2020-04-07 | 公開日 | 2020-12-02 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase III alpha within a flexible DNA repair complex. Nucleic Acids Res., 49, 2021
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4D05
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![BU of 4d05 by Molmil](/molmil-images/mine/4d05) | Structure and activity of a minimal-type ATP-dependent DNA ligase from a psychrotolerant bacterium | 分子名称: | ADENOSINE MONOPHOSPHATE, ATP-DEPENDENT DNA LIGASE, MAGNESIUM ION, ... | 著者 | Williamson, A, Rothweiler, U, Leiros, H.-K.S. | 登録日 | 2014-04-24 | 公開日 | 2014-11-12 | 最終更新日 | 2019-06-26 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Enzyme-Adenylate Structure of a Bacterial ATP-Dependent DNA Ligase with a Minimized DNA-Binding Surface Acta Crystallogr.,Sect.D, 70, 2014
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1TA8
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![BU of 1ta8 by Molmil](/molmil-images/mine/1ta8) | |
1ZAU
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![BU of 1zau by Molmil](/molmil-images/mine/1zau) | |
3VNN
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![BU of 3vnn by Molmil](/molmil-images/mine/3vnn) | Crystal Structure of a sub-domain of the nucleotidyltransferase (adenylation) domain of human DNA ligase IV | 分子名称: | DNA ligase 4 | 著者 | Ochi, T, Wu, Q, Chirgadze, D.Y, Grossmann, J.G, Bolanos-Garcia, V.M, Blundell, T.L. | 登録日 | 2012-01-17 | 公開日 | 2012-06-20 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.903 Å) | 主引用文献 | Structural insights into the role of domain flexibility in human DNA ligase IV Structure, 20, 2012
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3PN1
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![BU of 3pn1 by Molmil](/molmil-images/mine/3pn1) | Novel Bacterial NAD+-dependent DNA Ligase Inhibitors with Broad Spectrum Potency and Antibacterial Efficacy In Vivo | 分子名称: | 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 2-(butylsulfanyl)adenosine, DNA ligase | 著者 | Mills, S, Eakin, A, Buurman, E, Newman, J, Gao, N, Huynh, H, Johnson, K, Lahiri, S, Shapiro, A, Walkup, G, Wei, Y, Stokes, S. | 登録日 | 2010-11-18 | 公開日 | 2011-01-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo. Antimicrob.Agents Chemother., 55, 2011
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1DGS
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![BU of 1dgs by Molmil](/molmil-images/mine/1dgs) | CRYSTAL STRUCTURE OF NAD+-DEPENDENT DNA LIGASE FROM T. FILIFORMIS | 分子名称: | ADENOSINE MONOPHOSPHATE, DNA LIGASE, ZINC ION | 著者 | Lee, J.Y, Chang, C, Song, H.K, Kwon, S.T, Suh, S.W. | 登録日 | 1999-11-25 | 公開日 | 2000-11-27 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structure of NAD(+)-dependent DNA ligase: modular architecture and functional implications. EMBO J., 19, 2000
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5FRQ
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![BU of 5frq by Molmil](/molmil-images/mine/5frq) | |
6KKV
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![BU of 6kkv by Molmil](/molmil-images/mine/6kkv) | |
1IMO
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![BU of 1imo by Molmil](/molmil-images/mine/1imo) | |
1IN1
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![BU of 1in1 by Molmil](/molmil-images/mine/1in1) | |
2OWO
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![BU of 2owo by Molmil](/molmil-images/mine/2owo) | Last Stop on the Road to Repair: Structure of E.coli DNA Ligase Bound to Nicked DNA-Adenylate | 分子名称: | 26-MER, 5'-D(*AP*CP*AP*AP*TP*TP*GP*CP*GP*AP*CP*(OMC)P*C)-3', 5'-D(*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*AP*TP*G)-3', ... | 著者 | Shuman, S, Nandakumar, J, Nair, P.A. | 登録日 | 2007-02-16 | 公開日 | 2007-05-15 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Last Stop on the Road to Repair: Structure of E. coli DNA Ligase Bound to Nicked DNA-Adenylate. Mol.Cell, 26, 2007
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1X9N
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![BU of 1x9n by Molmil](/molmil-images/mine/1x9n) | Crystal Structure of Human DNA Ligase I bound to 5'-adenylated, nicked DNA | 分子名称: | 5'-phosphorylated DNA, ADENOSINE MONOPHOSPHATE, DNA ligase I, ... | 著者 | Pascal, J.M, O'Brien, P.J, Tomkinson, A.E, Ellenberger, T. | 登録日 | 2004-08-23 | 公開日 | 2004-11-30 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Human DNA ligase I completely encircles and partially unwinds nicked DNA. Nature, 432, 2004
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2Q2U
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![BU of 2q2u by Molmil](/molmil-images/mine/2q2u) | Structure of Chlorella virus DNA ligase-product DNA complex | 分子名称: | 5'-D(*AP*TP*TP*GP*CP*GP*AP*CP*(OMC)P*CP*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*A)-3', 5'-D(*TP*TP*CP*CP*GP*AP*TP*AP*GP*TP*GP*GP*GP*GP*TP*CP*GP*CP*AP*AP*T)-3', Chlorella virus DNA ligase | 著者 | Lima, C.D, Nandakumar, J, Nair, P.A, Smith, P, Shuman, S. | 登録日 | 2007-05-29 | 公開日 | 2007-07-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis for nick recognition by a minimal pluripotent DNA ligase. Nat.Struct.Mol.Biol., 14, 2007
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2Q2T
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![BU of 2q2t by Molmil](/molmil-images/mine/2q2t) | Structure of Chlorella virus DNA ligase-adenylate bound to a 5' phosphorylated nick | 分子名称: | 5'-D(*AP*TP*TP*GP*CP*GP*AP*CP*(OMC)P*C)-3', 5'-D(*TP*TP*CP*CP*GP*AP*TP*AP*GP*TP*GP*GP*GP*GP*TP*CP*GP*CP*AP*AP*T)-3', 5'-D(P*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*A)-3', ... | 著者 | Lima, C.D, Nandakumar, J, Nair, P.A, Smith, P, Shuman, S. | 登録日 | 2007-05-29 | 公開日 | 2007-07-10 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for nick recognition by a minimal pluripotent DNA ligase. Nat.Struct.Mol.Biol., 14, 2007
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6LW8
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![BU of 6lw8 by Molmil](/molmil-images/mine/6lw8) | Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis | 分子名称: | (4R)-4-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine, DNA ligase A, GLYCEROL, ... | 著者 | Ramachandran, R, Afsar, M, Shukla, A. | 登録日 | 2020-02-07 | 公開日 | 2021-02-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | 主引用文献 | Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A. J.Struct.Biol., 213, 2021
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4UFZ
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![BU of 4ufz by Molmil](/molmil-images/mine/4ufz) | Synthesis of Novel NAD Dependant DNA Ligase Inhibitors via Negishi Cross-Coupling: Development of SAR and Resistance Studies | 分子名称: | 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 5,7-bis(azanyl)-2-tert-butyl-4-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidine-6-carbonitrile, DNA LIGASE | 著者 | Murphy-Benenato, K.E, Boriack-Sjodin, P.A, Martinez-Botella, G, Carcanague, D, Gingipali, L, Gowravaram, M, Harang, J, Hale, M, Ioannidis, G, Jahic, H, Johnstone, M, Kutschke, A, Laganas, V.A, Loch, J, Oguto, H, Patel, S.J. | 登録日 | 2015-03-20 | 公開日 | 2015-10-28 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Negishi Cross-Coupling Enabled Synthesis of Novel Nad(+)-Dependent DNA Ligase Inhibitors and Sar Development. Bioorg.Med.Chem.Lett., 25, 2015
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3W1G
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![BU of 3w1g by Molmil](/molmil-images/mine/3w1g) | |
3W5O
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![BU of 3w5o by Molmil](/molmil-images/mine/3w5o) | Crystal Structure of Human DNA ligase IV | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA ligase 4, SULFATE ION | 著者 | Gu, X, Ochi, T, Blundell, T.L. | 登録日 | 2013-02-02 | 公開日 | 2013-04-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Structure of the catalytic region of DNA ligase IV in complex with an artemis fragment sheds light on double-strand break repair Structure, 21, 2013
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3W1B
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![BU of 3w1b by Molmil](/molmil-images/mine/3w1b) | |
5WFY
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![BU of 5wfy by Molmil](/molmil-images/mine/5wfy) | |
1FVI
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![BU of 1fvi by Molmil](/molmil-images/mine/1fvi) | CRYSTAL STRUCTURE OF CHLORELLA VIRUS DNA LIGASE-ADENYLATE | 分子名称: | ADENOSINE MONOPHOSPHATE, CHLORELLA VIRUS DNA LIGASE-ADENYLATE, SULFATE ION | 著者 | Odell, M, Sriskanda, V, Shuman, S, Nikolov, D.B. | 登録日 | 2000-09-20 | 公開日 | 2000-11-22 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of eukaryotic DNA ligase-adenylate illuminates the mechanism of nick sensing and strand joining. Mol.Cell, 6, 2000
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3L2P
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![BU of 3l2p by Molmil](/molmil-images/mine/3l2p) | Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching Between Two DNA Bound States | 分子名称: | 5'-D(*GP*CP*CP*AP*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*CP*CP*G)-3', 5'-D(*GP*TP*CP*GP*GP*AP*CP*TP*G)-3', 5'-D(P*CP*GP*GP*GP*AP*TP*GP*CP*GP*TP*C)-3', ... | 著者 | Cotner-Gohara, E.A, Kim, I.K, Hammel, M, Tainer, J.A, Tomkinson, A, Ellenberger, T. | 登録日 | 2009-12-15 | 公開日 | 2010-07-14 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching between Two DNA-Bound States. Biochemistry, 49, 2010
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