3PN1

Novel Bacterial NAD+-dependent DNA Ligase Inhibitors with Broad Spectrum Potency and Antibacterial Efficacy In Vivo

Summary for 3PN1

Entry DOI	10.2210/pdb3pn1/pdb
Descriptor	DNA ligase, 2-(butylsulfanyl)adenosine, 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, ... (4 entities in total)
Functional Keywords	atp grasp fold, ligase, dna, bacteria, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Haemophilus influenzae
Total number of polymer chains	1
Total formula weight	36411.29
Authors	Mills, S.,Eakin, A.,Buurman, E.,Newman, J.,Gao, N.,Huynh, H.,Johnson, K.,Lahiri, S.,Shapiro, A.,Walkup, G.,Wei, Y.,Stokes, S. (deposition date: 2010-11-18, release date: 2011-01-12, Last modification date: 2024-02-21)
Primary citation	Mills, S.D.,Eakin, A.E.,Buurman, E.T.,Newman, J.V.,Gao, N.,Huynh, H.,Johnson, K.D.,Lahiri, S.,Shapiro, A.B.,Walkup, G.K.,Yang, W.,Stokes, S.S. Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo. Antimicrob.Agents Chemother., 55:1088-1096, 2011 Cited by PubMed: 21189350 DOI: 10.1128/AAC.01181-10 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation