6PAR
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6VQU
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3GLB
| Crystal structure of the effector binding domain of a CATM variant (R156H) | 分子名称: | (2Z,4Z)-HEXA-2,4-DIENEDIOIC ACID, GLYCEROL, HTH-type transcriptional regulator catM, ... | 著者 | Ezezika, O.C, Craven, S.H, Neidle, E.L, Momany, C. | 登録日 | 2009-03-11 | 公開日 | 2009-05-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Inducer responses of BenM, a LysR-type transcriptional regulator from Acinetobacter baylyi ADP1. Mol.Microbiol., 72, 2009
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4WKQ
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6PAM
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6PAN
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6PAQ
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6PAO
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8C8B
| Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 48). | 分子名称: | 4-[[(2~{S})-1-(oxidanylamino)-1-oxidanylidene-propan-2-yl]amino]-~{N}-prop-2-enyl-quinazoline-2-carboxamide, DNA cross-link repair 1A protein, ZINC ION | 著者 | Yosaatmadja, Y, Newman, J.A, Baddock, H.T, Bielinski, M, von Delft, F, Bountra, C, McHugh, P.J, Schofield, C.J, Gileadi, O. | 登録日 | 2023-01-19 | 公開日 | 2024-01-31 | 最終更新日 | 2024-09-11 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target. Chem Sci, 15, 2024
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8C8S
| Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 21). | 分子名称: | (2~{R})-3-[6-chloranyl-2-(prop-2-enylamino)quinazolin-4-yl]-2-methyl-~{N}-oxidanyl-propanamide, DNA cross-link repair 1A protein, ZINC ION | 著者 | Yosaatmadja, Y, Newman, J.A, Baddock, H.T, Bielinski, M, von Delft, F, Bountra, C, McHugh, P.J, Schofield, C.J, Gileadi, O. | 登録日 | 2023-01-20 | 公開日 | 2024-01-31 | 最終更新日 | 2024-09-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target. Chem Sci, 15, 2024
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8C8D
| Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 44). | 分子名称: | (2~{R})-3-[6-chloranyl-2-(furan-2-ylmethylamino)quinazolin-4-yl]-2-methyl-~{N}-oxidanyl-propanamide, DNA cross-link repair 1A protein, ZINC ION | 著者 | Yosaatmadja, Y, Newman, J.A, Baddock, H.T, Bielinski, M, von Delft, F, Bountra, C, McHugh, P.J, Schofield, C.J, Gileadi, O. | 登録日 | 2023-01-19 | 公開日 | 2024-01-31 | 最終更新日 | 2024-09-11 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target. Chem Sci, 15, 2024
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6VQT
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7AFS
| The structure of Artemis variant D37A | 分子名称: | 1,2-ETHANEDIOL, NICKEL (II) ION, Protein artemis, ... | 著者 | Yosaatmadja, Y, Goubin, S, Newman, J.A, Mukhopadhyay, S.M.M, Dannerfjord, A.A, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Gileadi, O. | 登録日 | 2020-09-20 | 公開日 | 2020-10-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. Nucleic Acids Res., 49, 2021
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7AGI
| The structure of Artemis variant H35D | 分子名称: | 1,2-ETHANEDIOL, Protein artemis, ZINC ION | 著者 | Yosaatmadja, Y, Goubin, S, Newman, J.A, Mukhopadhyay, S.M.M, Dannerfjord, A.A, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Gileadi, O. | 登録日 | 2020-09-22 | 公開日 | 2020-10-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. Nucleic Acids Res., 49, 2021
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7APV
| Structure of Artemis/DCLRE1C/SNM1C in complex with Ceftriaxone | 分子名称: | 1,2-ETHANEDIOL, Ceftriaxone, NICKEL (II) ION, ... | 著者 | Yosaatmadja, Y, Goubin, S, Newman, J.A, Mukhopadhyay, S.M.M, Dannerfjord, A.A, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Gileadi, O. | 登録日 | 2020-10-20 | 公開日 | 2020-12-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. Nucleic Acids Res., 49, 2021
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7AF1
| The structure of Artemis/SNM1C/DCLRE1C with 2 Zinc ions | 分子名称: | 1,2-ETHANEDIOL, Protein artemis, ZINC ION | 著者 | Yosaatmadja, Y, Goubin, S, Newman, J.A, Mukhopadhyay, S.M.M, Dannerfjord, A.A, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Gileadi, O. | 登録日 | 2020-09-19 | 公開日 | 2020-10-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. Nucleic Acids Res., 49, 2021
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7AFU
| The structure of Artemis variant H33A | 分子名称: | 1,2-ETHANEDIOL, Protein artemis, ZINC ION | 著者 | Yosaatmadja, Y, Goubin, S, Newman, J.A, Mukhopadhyay, S.M.M, Dannerfjord, A.A, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Gileadi, O. | 登録日 | 2020-09-20 | 公開日 | 2020-10-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. Nucleic Acids Res., 49, 2021
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6TT5
| Crystal structure of DCLRE1C/Artemis | 分子名称: | 1,2-ETHANEDIOL, NICKEL (II) ION, Protein artemis, ... | 著者 | Yosaatmadja, Y, Goubin, S, Newman, J.A, Mukhopadhyay, S.M.M, Dannerfjord, A.A, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | 登録日 | 2019-12-23 | 公開日 | 2020-02-12 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. Nucleic Acids Res., 49, 2021
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4JQ4
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4JQ1
| AKR1C2 complex with naproxen | 分子名称: | (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid, 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member C2, ... | 著者 | Yosaatmadja, Y, Flanagan, J.U, Squire, C.J. | 登録日 | 2013-03-19 | 公開日 | 2014-04-02 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural basis of NSAID selectivity for the aldo-keto reductase 1C family To be Published
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4JQ3
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4JQ2
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4JTR
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4JQA
| AKR1C2 complex with mefenamic acid | 分子名称: | 1,2-ETHANEDIOL, 2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID, Aldo-keto reductase family 1 member C2, ... | 著者 | Yosaatmadja, Y, Flanagan, J.U, Squire, C.J. | 登録日 | 2013-03-20 | 公開日 | 2014-04-02 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural basis of NSAID selectivity for the aldo-keto reductase 1C family To be Published
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4JTQ
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