8C8D

Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 44).

Summary for 8C8D

• Entry DOI: 10.2210/pdb8c8d/pdb
• Descriptor: DNA cross-link repair 1A protein, (2~{R})-3-[6-chloranyl-2-(furan-2-ylmethylamino)quinazolin-4-yl]-2-methyl-~{N}-oxidanyl-propanamide, ZINC ION, ... (4 entities in total)
• Functional Keywords: exonuclease, snm1a, nuclease inhibition, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 39774.48

Authors

Yosaatmadja, Y.,Newman, J.A.,Baddock, H.T.,Bielinski, M.,von Delft, F.,Bountra, C.,McHugh, P.J.,Schofield, C.J.,Gileadi, O. (deposition date: 2023-01-19, release date: 2024-01-31)

• Primary citation: Yosaatmadja, Y.,Newman, J.A.,Baddock, H.T.,Bielinski, M.,von Delft, F.,Bountra, C.,McHugh, P.J.,Schofield, C.J.,Gileadi, O.; Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 44).; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.46 Å)