7AFU

The structure of Artemis variant H33A

Summary for 7AFU

Entry DOI	10.2210/pdb7afu/pdb
Related	6TT5
Descriptor	Protein artemis, ZINC ION, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	artemis, snm1c, dclre1c, nuclease, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	42454.17
Authors	Yosaatmadja, Y.,Goubin, S.,Newman, J.A.,Mukhopadhyay, S.M.M.,Dannerfjord, A.A.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Gileadi, O. (deposition date: 2020-09-20, release date: 2020-10-28, Last modification date: 2024-01-31)
Primary citation	Yosaatmadja, Y.,Baddock, H.T.,Newman, J.A.,Bielinski, M.,Gavard, A.E.,Mukhopadhyay, S.M.M.,Dannerfjord, A.A.,Schofield, C.J.,McHugh, P.J.,Gileadi, O. Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. Nucleic Acids Res., 49:9310-9326, 2021 Cited by PubMed: 34387696 DOI: 10.1093/nar/gkab693 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.56 Å)

Structure validation