8C8B

Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 48).

Summary for 8C8B

• Entry DOI: 10.2210/pdb8c8b/pdb
• Descriptor: DNA cross-link repair 1A protein, 4-[[(2~{S})-1-(oxidanylamino)-1-oxidanylidene-propan-2-yl]amino]-~{N}-prop-2-enyl-quinazoline-2-carboxamide, ZINC ION, ... (4 entities in total)
• Functional Keywords: exonuclease, snm1a, nuclease inhibition, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 39368.21

Authors

Yosaatmadja, Y.,Newman, J.A.,Baddock, H.T.,Bielinski, M.,von Delft, F.,Bountra, C.,McHugh, P.J.,Schofield, C.J.,Gileadi, O. (deposition date: 2023-01-19, release date: 2024-01-31)

• Primary citation: Yosaatmadja, Y.,Newman, J.A.,Baddock, H.T.,Bielinski, M.,von Delft, F.,Bountra, C.,McHugh, P.J.,Schofield, C.J.,Gileadi, O.; Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 21).; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.46 Å)