5W1R
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![BU of 5w1r by Molmil](/molmil-images/mine/5w1r) | Cryo-EM structure of DNAPKcs | 分子名称: | DNA-dependent protein kinase catalytic subunit | 著者 | Sharif, H, Li, Y, Wu, H. | 登録日 | 2017-06-04 | 公開日 | 2017-07-19 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Cryo-EM structure of the DNA-PK holoenzyme. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8BHV
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![BU of 8bhv by Molmil](/molmil-images/mine/8bhv) | |
8BH3
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![BU of 8bh3 by Molmil](/molmil-images/mine/8bh3) | |
6IG9
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![BU of 6ig9 by Molmil](/molmil-images/mine/6ig9) | |
7LT3
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![BU of 7lt3 by Molmil](/molmil-images/mine/7lt3) | NHEJ Long-range synaptic complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (30-MER), DNA (31-MER), ... | 著者 | He, Y, Chen, S. | 登録日 | 2021-02-18 | 公開日 | 2021-04-14 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Structural basis of long-range to short-range synaptic transition in NHEJ. Nature, 593, 2021
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7OWG
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![BU of 7owg by Molmil](/molmil-images/mine/7owg) | human DEPTOR in a complex with mutant human mTORC1 A1459P | 分子名称: | DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ... | 著者 | Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L. | 登録日 | 2021-06-18 | 公開日 | 2021-09-08 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace. Elife, 10, 2021
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7WZR
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![BU of 7wzr by Molmil](/molmil-images/mine/7wzr) | Cryo-EM structure of Mec1-HU | 分子名称: | DNA damage checkpoint protein LCD1, Serine/threonine-protein kinase MEC1 | 著者 | Zhang, Q, Zhang, Q. | 登録日 | 2022-02-19 | 公開日 | 2023-03-08 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Structures of Mec1/ATR kinase endogenously stimulated by different genotoxins. Cell Discov, 8, 2022
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5YZ0
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![BU of 5yz0 by Molmil](/molmil-images/mine/5yz0) | Cryo-EM Structure of human ATR-ATRIP complex | 分子名称: | ATR-interacting protein, Serine/threonine-protein kinase ATR | 著者 | Rao, Q, Liu, M, Tian, Y, Wu, Z, Wang, H, Wang, J, Xu, Y. | 登録日 | 2017-12-11 | 公開日 | 2018-01-31 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Cryo-EM structure of human ATR-ATRIP complex. Cell Res., 28, 2018
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5Y81
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![BU of 5y81 by Molmil](/molmil-images/mine/5y81) | NuA4 TEEAA sub-complex | 分子名称: | Actin, Actin-related protein 4, Chromatin modification-related protein EAF1, ... | 著者 | Wang, X, Cai, G. | 登録日 | 2017-08-18 | 公開日 | 2018-04-18 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex Nat Commun, 9, 2018
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5ZCS
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![BU of 5zcs by Molmil](/molmil-images/mine/5zcs) | 4.9 Angstrom Cryo-EM structure of human mTOR complex 2 | 分子名称: | Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... | 著者 | Chen, X, Liu, M, Tian, Y, Wang, H, Wang, J, Xu, Y. | 登録日 | 2018-02-20 | 公開日 | 2018-03-21 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | 主引用文献 | Cryo-EM structure of human mTOR complex 2. Cell Res., 28, 2018
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8BHY
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6SB0
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![BU of 6sb0 by Molmil](/molmil-images/mine/6sb0) | cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ... | 著者 | Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. | 登録日 | 2019-07-18 | 公開日 | 2019-10-16 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | 主引用文献 | Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
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8EZ9
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![BU of 8ez9 by Molmil](/molmil-images/mine/8ez9) | Dimeric complex of DNA-PKcs | 分子名称: | DNA-dependent protein kinase catalytic subunit, unknown region of DNA-PKcs | 著者 | Chen, S, He, Y. | 登録日 | 2022-10-31 | 公開日 | 2023-06-14 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (5.67 Å) | 主引用文献 | Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. Sci Adv, 9, 2023
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5NP0
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![BU of 5np0 by Molmil](/molmil-images/mine/5np0) | Closed dimer of human ATM (Ataxia telangiectasia mutated) | 分子名称: | Serine-protein kinase ATM | 著者 | Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L. | 登録日 | 2017-04-13 | 公開日 | 2017-05-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | 主引用文献 | Structures of closed and open conformations of dimeric human ATM. Sci Adv, 3, 2017
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5OEJ
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![BU of 5oej by Molmil](/molmil-images/mine/5oej) | Structure of Tra1 subunit within the chromatin modifying complex SAGA | 分子名称: | Tra1 subunit within the chromatin modifying complex SAGA | 著者 | Sharov, G, Voltz, K, Durand, A, Kolesnikova, O, Papai, G, Myasnikov, A.G, Dejaegere, A, Ben-Shem, A, Schultz, P. | 登録日 | 2017-07-07 | 公開日 | 2017-08-02 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | 主引用文献 | Structure of the transcription activator target Tra1 within the chromatin modifying complex SAGA. Nat Commun, 8, 2017
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5NP1
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![BU of 5np1 by Molmil](/molmil-images/mine/5np1) | Open protomer of human ATM (Ataxia telangiectasia mutated) | 分子名称: | Serine-protein kinase ATM | 著者 | Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L. | 登録日 | 2017-04-13 | 公開日 | 2017-05-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | 主引用文献 | Structures of closed and open conformations of dimeric human ATM. Sci Adv, 3, 2017
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5FLC
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![BU of 5flc by Molmil](/molmil-images/mine/5flc) | Architecture of human mTOR Complex 1 - 5.9 Angstrom reconstruction | 分子名称: | FKBP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, REGULATORY-ASSOCIATED PROTEIN OF MTOR, ... | 著者 | Aylett, C.H.S, Sauer, E, Imseng, S, Boehringer, D, Hall, M.N, Ban, N, Maier, T. | 登録日 | 2015-10-23 | 公開日 | 2015-12-30 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | Architecture of Human Mtor Complex 1 Science, 351, 2016
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4D0M
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![BU of 4d0m by Molmil](/molmil-images/mine/4d0m) | Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3 | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE, ... | 著者 | Burke, J.E, Inglis, A.J, Perisic, O, Masson, G.R, McLaughlin, S.H, Rutaganira, F, Shokat, K.M, Williams, R.L. | 登録日 | 2014-04-29 | 公開日 | 2014-05-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (6 Å) | 主引用文献 | Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors. Science, 344, 2014
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6SB2
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![BU of 6sb2 by Molmil](/molmil-images/mine/6sb2) | cryo-EM structure of mTORC1 bound to active RagA/C GTPases | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Ras-related GTP-binding protein A, ... | 著者 | Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. | 登録日 | 2019-07-18 | 公開日 | 2019-10-16 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | 主引用文献 | Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
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5Y3R
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![BU of 5y3r by Molmil](/molmil-images/mine/5y3r) | Cryo-EM structure of Human DNA-PK Holoenzyme | 分子名称: | DNA (34-MER), DNA (36-MER), DNA-dependent protein kinase catalytic subunit, ... | 著者 | Yin, X, Liu, M, Tian, Y, Wang, J, Xu, Y. | 登録日 | 2017-07-29 | 公開日 | 2017-09-06 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | 主引用文献 | Cryo-EM structure of human DNA-PK holoenzyme Cell Res., 27, 2017
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9C82
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![BU of 9c82 by Molmil](/molmil-images/mine/9c82) | Structure of human ULK1C:PI3KC3-C1 supercomplex | 分子名称: | Beclin 1-associated autophagy-related key regulator, Beclin-1, Phosphatidylinositol 3-kinase catalytic subunit type 3, ... | 著者 | Chen, M, Hurley, J.H. | 登録日 | 2024-06-11 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (6.84 Å) | 主引用文献 | Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex bioRxiv, 2023
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6ZHE
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![BU of 6zhe by Molmil](/molmil-images/mine/6zhe) | Cryo-EM structure of DNA-PK dimer | 分子名称: | DNA (25-MER), DNA (26-MER), DNA (27-MER), ... | 著者 | Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. | 登録日 | 2020-06-23 | 公開日 | 2020-10-21 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (7.24 Å) | 主引用文献 | Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021
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8BOT
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6K9K
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![BU of 6k9k by Molmil](/molmil-images/mine/6k9k) | Monomeric human ATM (Ataxia telangiectasia mutated) kinase | 分子名称: | Serine-protein kinase ATM | 著者 | Xiao, J, Liu, M, Qi, Y, Yuriy, C, Zhang, P, Xu, Y. | 登録日 | 2019-06-16 | 公開日 | 2019-12-25 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (7.82 Å) | 主引用文献 | Structural insights into the activation of ATM kinase. Cell Res., 29, 2019
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6EMK
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![BU of 6emk by Molmil](/molmil-images/mine/6emk) | Cryo-EM Structure of Saccharomyces cerevisiae Target of Rapamycin Complex 2 | 分子名称: | Serine/threonine-protein kinase TOR2, Target of rapamycin complex 2 subunit AVO1, Target of rapamycin complex 2 subunit AVO2, ... | 著者 | Karuppasamy, M, Kusmider, B, Oliveira, T.M, Gaubitz, C, Prouteau, M, Loewith, R, Schaffitzel, C. | 登録日 | 2017-10-02 | 公開日 | 2017-12-06 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (7.9 Å) | 主引用文献 | Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2. Nat Commun, 8, 2017
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