2C5N
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![BU of 2c5n by Molmil](/molmil-images/mine/2c5n) | Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design | 分子名称: | CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINE | 著者 | Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M. | 登録日 | 2005-10-30 | 公開日 | 2006-03-01 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006
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2CCI
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![BU of 2cci by Molmil](/molmil-images/mine/2cci) | Crystal structure of phospho-CDK2 Cyclin A in complex with a peptide containing both the substrate and recruitment sites of CDC6 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6 homolog, Cyclin-A2, ... | 著者 | Cheng, K.Y, Noble, M.E.M, Skamnaki, V, Brown, N.R, Lowe, E.D, Kontogiannis, L, Shen, K, Cole, P.A, Siligardi, G, Johnson, L.N. | 登録日 | 2006-01-16 | 公開日 | 2006-05-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition. J. Biol. Chem., 281, 2006
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4L43
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![BU of 4l43 by Molmil](/molmil-images/mine/4l43) | Crystal structures of human p70S6K1-T389A (form I) | 分子名称: | 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole, RPS6KB1 protein | 著者 | Wang, J, Zhong, C, Ding, J. | 登録日 | 2013-06-07 | 公開日 | 2013-07-24 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif Biochem.J., 454, 2013
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2CJM
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![BU of 2cjm by Molmil](/molmil-images/mine/2cjm) | Mechanism of CDK inhibition by active site phosphorylation: CDK2 Y15p T160p in complex with cyclin A structure | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ... | 著者 | Welburn, J.P.I, Tucker, J, Johnson, T, Lindert, L, Morgan, M, Willis, A, Noble, M.E.M, Endicott, J.A. | 登録日 | 2006-04-05 | 公開日 | 2006-04-24 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | How Tyrosine 15 Phosphorylation Inhibits the Activity of Cyclin-Dependent Kinase 2-Cyclin A. J.Biol.Chem., 282, 2007
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4L9I
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2CMW
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![BU of 2cmw by Molmil](/molmil-images/mine/2cmw) | Structure of Human Casein kinase 1 gamma-1 in complex with 2-(2- Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | 分子名称: | 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE, ACETATE ION, CASEIN KINASE I ISOFORM GAMMA-1, ... | 著者 | Bunkoczi, G, Rellos, P, Das, S, Savitsky, P, Niesen, F, Sobott, F, Fedorov, O, Pike, A.C.W, von Delft, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Weigelt, J, Knapp, S. | 登録日 | 2006-05-15 | 公開日 | 2006-06-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structure of Human Casein Kinase 1 Gamma-1 in Complex with 2-(2-Hydroxyethylamino)-6-(3-Chloroanilino)-9-Isopropylpurine (Casp Target) To be Published
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2CCH
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![BU of 2cch by Molmil](/molmil-images/mine/2cch) | The crystal structure of CDK2 cyclin A in complex with a substrate peptide derived from CDC modified with a gamma-linked ATP analogue | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION CONTROL PROTEIN 6 HOMOLOG, CELL DIVISION PROTEIN KINASE 2, ... | 著者 | Cheng, K.Y, Noble, M.E.M, Skamnaki, V, Brown, N.R, Lowe, E.D, Kontogiannis, L, Shen, K, Cole, P.A, Siligardi, G, Johnson, L.N. | 登録日 | 2006-01-16 | 公開日 | 2006-05-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The Role of the Phospho-Cdk2/Cyclin a Recruitment Site in Substrate Recognition J.Biol.Chem., 281, 2006
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2CHL
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![BU of 2chl by Molmil](/molmil-images/mine/2chl) | Structure of casein kinase 1 gamma 3 | 分子名称: | 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, CASEIN KINASE I ISOFORM GAMMA-3, SULFATE ION | 著者 | Bunkoczi, G, Salah, E, Rellos, P, Das, S, Fedorov, O, Savitsky, P, Gileadi, O, Sundstrom, M, Edwards, A, Arrowsmith, C, Ugochukwu, E, Weigelt, J, von Delft, F, Knapp, S. | 登録日 | 2006-03-15 | 公開日 | 2006-03-22 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure of Casein Kinase 1 Gamma 3 To be Published
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4M69
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![BU of 4m69 by Molmil](/molmil-images/mine/4m69) | Crystal structure of the mouse RIP3-MLKL complex | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Mixed lineage kinase domain-like protein, ... | 著者 | Xie, T, Peng, W, Yan, C, Wu, J, Shi, Y. | 登録日 | 2013-08-09 | 公開日 | 2013-10-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.497 Å) | 主引用文献 | Structural Insights into RIP3-Mediated Necroptotic Signaling Cell Rep, 5, 2013
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4MD7
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4MNE
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![BU of 4mne by Molmil](/molmil-images/mine/4mne) | Crystal structure of the BRAF:MEK1 complex | 分子名称: | 7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-{[(2S)-2-hydroxypropyl]oxy}furo[3,2-c]pyridine-2-carboxamide, CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Sudhamsu, J, Haling, J.R, Morales, T, Brandhuber, B, Hymowitz, S.G. | 登録日 | 2013-09-10 | 公開日 | 2014-06-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8483 Å) | 主引用文献 | Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling. Cancer Cell, 26, 2014
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2C4G
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![BU of 2c4g by Molmil](/molmil-images/mine/2c4g) | STRUCTURE OF CDK2-CYCLIN A WITH PHA-533514 | 分子名称: | (3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ... | 著者 | Cameron, A, Fogliatto, G, Pevarello, P, Fancelli, D, Vulpetti, A, Amici, R, Villa, M, Pittala, V, Ciomei, M, Mercurio, C, Bischoff, J.R, Roletto, F, Varasi, M, Brasca, M.G. | 登録日 | 2005-10-19 | 公開日 | 2005-11-23 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | 3-Amino-1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazoles: A New Class of Cdk2 Inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
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4M84
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4MD9
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2C5X
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![BU of 2c5x by Molmil](/molmil-images/mine/2c5x) | Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design | 分子名称: | CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUM | 著者 | Kontopidis, G, Mcinnes, C, Pandalaneni, S.R, Mcnae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M. | 登録日 | 2005-11-03 | 公開日 | 2006-03-01 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006
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4L67
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![BU of 4l67 by Molmil](/molmil-images/mine/4l67) | Crystal Structure of Catalytic Domain of PAK4 | 分子名称: | Serine/threonine-protein kinase PAK 4 | 著者 | Wang, W, Song, J. | 登録日 | 2013-06-12 | 公開日 | 2013-08-14 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | NMR binding and crystal structure reveal that intrinsically-unstructured regulatory domain auto-inhibits PAK4 by a mechanism different for that of PAK1 Biochem.Biophys.Res.Commun., 438, 2013
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4MVF
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![BU of 4mvf by Molmil](/molmil-images/mine/4mvf) | Crystal Structure of Plasmodium falciparum CDPK2 complexed with inhibitor staurosporine | 分子名称: | CALCIUM ION, Calcium-dependent protein kinase 2, GLYCEROL, ... | 著者 | Lauciello, L, Pernot, L, Scapozza, L, Perozzo, R. | 登録日 | 2013-09-24 | 公開日 | 2014-09-03 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | P. falciparum Calcium-Dependent Protein Kinase 2 (PfCDPK2): First Crystal Structure and Virtual Ligand Screening To be Published
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4MK0
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![BU of 4mk0 by Molmil](/molmil-images/mine/4mk0) | |
4LQS
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![BU of 4lqs by Molmil](/molmil-images/mine/4lqs) | Crystal structure of the Cbk1-Mob2 kinase-coactivator complex | 分子名称: | CBK1 kinase activator protein MOB2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase CBK1 | 著者 | Gogl, G, Remenyi, A. | 登録日 | 2013-07-19 | 公開日 | 2014-07-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism. Plos Biol., 13, 2015
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4M97
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![BU of 4m97 by Molmil](/molmil-images/mine/4m97) | |
4LQP
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2BFY
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![BU of 2bfy by Molmil](/molmil-images/mine/2bfy) | Complex of Aurora-B with INCENP and Hesperadin. | 分子名称: | AURORA KINASE B-A, INNER CENTROMERE PROTEIN A, N-[2-OXO-3-((E)-PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]IMINO}METHYL)-2,6-DIHYDRO-1H-INDOL-5-YL]ETHANESULFONAMIDE | 著者 | Sessa, F, Mapelli, M, Ciferri, C, Tarricone, C, Areces, L.B, Schneider, T.R, Stukenberg, P.T, Musacchio, A. | 登録日 | 2004-12-15 | 公開日 | 2005-05-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin Mol.Cell, 18, 2005
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2BFX
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![BU of 2bfx by Molmil](/molmil-images/mine/2bfx) | Mechanism of Aurora-B activation by INCENP and inhibition by Hesperadin. | 分子名称: | AURORA KINASE B-A, INNER CENTROMERE PROTEIN A | 著者 | Sessa, F, Mapelli, M, Ciferri, C, Tarricone, C, Areces, L.B, Schneider, T.R, Stukenberg, P.T, Musacchio, A. | 登録日 | 2004-12-15 | 公開日 | 2005-05-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanism of Aurora B Activation by Incenp and Inhibition by Hesperadin Mol.Cell, 18, 2005
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2C6T
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![BU of 2c6t by Molmil](/molmil-images/mine/2c6t) | Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor | 分子名称: | 4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2 | 著者 | Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. | 登録日 | 2005-11-11 | 公開日 | 2005-12-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar. Bioorg.Med.Chem.Lett., 16, 2006
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4LGD
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![BU of 4lgd by Molmil](/molmil-images/mine/4lgd) | Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5 | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ras association domain family member 5, ... | 著者 | Luo, X, Ni, L, Tomchick, D.R. | 登録日 | 2013-06-27 | 公開日 | 2013-09-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5. Structure, 21, 2013
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