PDB: 541 件ウェブページステータス検索Chemie searchBIRD

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4G82	Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element 分子名称: DNA (5'-D(P*GP*AP*AP*CP*AP*TP*GP*TP*TP*C)-3'), Tumor protein p73, ZINC ION 著者 Ethayathulla, A.S, Viadiu, H. 登録日 2012-07-20 公開日 2013-01-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element J.Biol.Chem., 2013
4GUO	structure of p73 DNA binding domain complex with 12 bp DNA 分子名称: DNA (5'-D(*CP*GP*GP*GP*CP*AP*AP*GP*CP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*GP*CP*TP*TP*GP*CP*CP*CP*G)-3'), Tumor protein p73, ... 著者 Ethayathulla, A.S, Viadiu, H. 登録日 2012-08-29 公開日 2013-11-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.19 Å) 主引用文献 structure of p73 DNA binding domain complex with 12 bp DNA To be Published
5VK0	Crystal structure of human MDM2 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI 分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, Lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI 著者 Tolbert, W.D, Gohain, N, Pazgier, M. 登録日 2017-04-20 公開日 2018-04-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design. Chem Sci, 10, 2019
3S7J	Structural Basis of Substrate Methylation and Inhibition of SMYD2 分子名称: N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ZINC ION 著者 Ferguson, A.D. 登録日 2011-05-26 公開日 2011-08-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.04 Å) 主引用文献 Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure, 19, 2011
1D5F	STRUCTURE OF E6AP: INSIGHTS INTO UBIQUITINATION PATHWAY 分子名称: E6AP HECT CATALYTIC DOMAIN, E3 LIGASE 著者 Huang, L, Kinnucan, E, Wang, G, Beaudenon, S, Howley, P.M, Huibregtse, J.M, Pavletich, N.P. 登録日 1999-10-07 公開日 1999-11-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Science, 286, 1999
3S7B	Structural Basis of Substrate Methylation and Inhibition of SMYD2 分子名称: (R,R)-2,3-BUTANEDIOL, N-cyclohexyl-N~3~-[2-(3,4-dichlorophenyl)ethyl]-N-(2-{[2-(5-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}ethyl)-beta-alaninamide, N-lysine methyltransferase SMYD2, ... 著者 Ferguson, A.D. 登録日 2011-05-26 公開日 2011-08-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure, 19, 2011
6HKP	Factor Inhibiting HIF (FIH) in complex with zinc, NOG and ASPP2 (970-992) 分子名称: Apoptosis-stimulating of p53 protein 2, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ... 著者 Leissing, T.M, Clifton, I.J, Lu, X, Schofield, C.J. 登録日 2018-09-07 公開日 2019-09-18 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Factor Inhibiting HIF (FIH) in complex with zinc, NOG and ASPP2 (970-992) To Be Published
7VOV	The crystal structure of human forkhead box protein in complex with DNA 2 分子名称: DNA (5'-D(P*AP*AP*AP*TP*AP*TP*TP*TP*AP*TP*TP*AP*TP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*AP*TP*AP*AP*TP*AP*AP*AP*TP*AP*TP*T)-3'), Forkhead box protein L2 著者 Choi, Y, Yoon, H.J, Lee, H.H. 登録日 2021-10-15 公開日 2022-08-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations. Nucleic Acids Res., 50, 2022
7VOU	The crystal structure of human forkhead box protein in complex with DNA 1 分子名称: DNA (5'-D(*AP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*T)-3'), Forkhead box protein L2 著者 Choi, Y, Yoon, H.J, Lee, H.H. 登録日 2021-10-14 公開日 2022-08-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations. Nucleic Acids Res., 50, 2022
7VOX	The crystal structure of human forkhead box protein A in complex with DNA 2 分子名称: DNA (5'-D(P*AP*AP*AP*TP*AP*TP*TP*TP*AP*TP*TP*AP*TP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*AP*TP*AP*AP*TP*AP*AP*AP*TP*AP*TP*TP*T)-3'), Hepatocyte nuclear factor 3-alpha, ... 著者 Choi, Y, Yoon, H.J, Lee, H.H. 登録日 2021-10-15 公開日 2022-08-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations. Nucleic Acids Res., 50, 2022
5DKR	Crystal Structure of Calcium-loaded S100B bound to SBi29 分子名称: 2-[4-(4-carbamimidoylphenoxy)phenyl]-1H-indole-6-carboximidamide, CALCIUM ION, Protein S100-B 著者 Cavalier, M.C, Ansari, M.I, Pierce, A.D, Wilder, P.T, McKnight, L.E, Raman, E.P, Neau, D.B, Bezawada, P, Alasady, M.J, Varney, K.M, Toth, E.A, MacKerell Jr, A.D, Coop, A, Weber, D.J. 登録日 2015-09-03 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.742 Å) 主引用文献 Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations. J.Med.Chem., 59, 2016
5DKQ	Crystal Structure of Calcium-loaded S100B bound to SBi4214 分子名称: 2,2'-[pentane-1,5-diylbis(oxybenzene-4,1-diyl)]di-1,4,5,6-tetrahydropyrimidine, CALCIUM ION, Protein S100-B 著者 Cavalier, M.C, Ansari, M.I, Pierce, A.D, Wilder, P.T, McKnight, L.E, Raman, E.P, Neau, D.B, Bezawada, P, Alasady, M.J, Varney, K.M, Toth, E.A, MacKerell Jr, A.D, Coop, A, Weber, D.J. 登録日 2015-09-03 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.591 Å) 主引用文献 Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations. J.Med.Chem., 59, 2016
5DKN	Crystal Structure of Calcium-loaded S100B bound to SBi4225 分子名称: 2,2'-[heptane-1,7-diylbis(oxybenzene-4,1-diyl)]bis(1H-imidazole), CALCIUM ION, Protein S100-B 著者 Cavalier, M.C, Ansari, M.I, Pierce, A.D, Wilder, P.T, McKnight, L.E, Raman, E.P, Neau, D.B, Bezawada, P, Alasady, M.J, Varney, K.M, Toth, E.A, MacKerell Jr, A.D, Coop, A, Weber, D.J. 登録日 2015-09-03 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.528 Å) 主引用文献 Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations. J.Med.Chem., 59, 2016
2L84	Solution NMR structures of CBP bromodomain with small molecule j28 分子名称: 5-[(E)-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid, CREB-binding protein 著者 Borah, J.C, Mujtaba, S, Karakikes, I, Zeng, L, Muller, M, Patel, J, Moshkina, N, Morohashi, K, Zhang, W, Gerona-Navarro, G, Hajjar, R.J, Zhou, M. 登録日 2011-01-03 公開日 2011-01-19 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes. Chem.Biol., 18, 2011
2L85	Solution NMR structures of CBP bromodomain with small molecule of HBS 分子名称: 4-[(E)-(4-hydroxyphenyl)diazenyl]benzenesulfonic acid, CREB-binding protein 著者 Borah, J.C, Mujtaba, S, Karakikes, I, Zeng, L, Muller, M, Patel, J, Moshkina, N, Morohashi, K, Zhang, W, Gerona-Navarro, G, Hajjar, R.J, Zhou, M. 登録日 2011-01-04 公開日 2011-01-19 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes. Chem.Biol., 18, 2011
5FA5	Crystal Structure of PRMT5:MEP50 in complex with MTA and H4 peptide 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Histone H4, Methylosome protein 50, ... 著者 Sprague, E.R, McNamara, J.T. 登録日 2015-12-10 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5. Science, 351, 2016
2C6B	Solution structure of the C4 zinc-finger domain of HDM2 分子名称: UBIQUITIN-PROTEIN LIGASE E3 MDM2, ZINC ION 著者 Yu, G.W, Allen, M.D, Andreeva, A, Fersht, A.R, Bycroft, M. 登録日 2005-11-08 公開日 2006-01-04 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution Structure of the C4 Zinc Finger Domain of Hdm2. Protein Sci., 15, 2006
5KJK	SMYD2 in complex with AZ370 分子名称: (R,R)-2,3-BUTANEDIOL, 2-[2-[1-[2-(3,4-dichlorophenyl)ethyl]azetidin-3-yl]oxyphenyl]-~{N}-(3-pyrrolidin-1-ylpropyl)pyridine-4-carboxamide, N-lysine methyltransferase SMYD2, ... 著者 Ferguson, A. 登録日 2016-06-20 公開日 2016-12-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors. J. Med. Chem., 59, 2016
5KJL	SMYD2 in complex with AZ378 分子名称: N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ZINC ION 著者 Ferguson, A. 登録日 2016-06-20 公開日 2016-12-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors. J. Med. Chem., 59, 2016
5KJN	SMYD2 in complex with AZ506 分子名称: (R,R)-2,3-BUTANEDIOL, 5-[2-[4-[2-(1~{H}-indol-3-yl)ethyl]piperazin-1-yl]phenyl]-~{N}-(3-pyrrolidin-1-ylpropyl)pyridine-3-carboxamide, N-lysine methyltransferase SMYD2, ... 著者 Ferguson, A. 登録日 2016-06-20 公開日 2016-12-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors. J. Med. Chem., 59, 2016
2C6A	Solution structure of the C4 zinc-finger domain of HDM2 分子名称: UBIQUITIN-PROTEIN LIGASE E3 MDM2, ZINC ION 著者 Yu, G.W, Allen, M.D, Andreeva, A, Fersht, A.R, Bycroft, M. 登録日 2005-11-08 公開日 2006-01-04 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution Structure of the C4 Zinc Finger Domain of Hdm2. Protein Sci., 15, 2006
5KJM	SMYD2 in complex with AZ931 分子名称: 6-[2-[4-[2-(3,4-dichlorophenyl)ethyl]piperazin-1-yl]phenyl]-~{N}-(3-pyrrolidin-1-ylpropyl)-2~{H}-pyrazolo[3,4-b]pyridine-4-carboxamide, N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ... 著者 Ferguson, A. 登録日 2016-06-20 公開日 2016-12-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors. J. Med. Chem., 59, 2016
2FK4	Solution structure of the C-terminal zinc binding domain of the HPV16 E6 oncoprotein 分子名称: Protein E6, ZINC ION 著者 Nomine, Y, Charbonnier, S. 登録日 2006-01-04 公開日 2006-01-24 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Structural and functional analysis of E6 oncoprotein: insights in the molecular pathways of human papillomavirus-mediated pathogenesis Mol.Cell, 21, 2006
1NB8	Structure of the catalytic domain of USP7 (HAUSP) 分子名称: Ubiquitin carboxyl-terminal hydrolase 7 著者 Hu, M, Li, P, Li, M, Li, W, Yao, T, Wu, J.-W, Gu, W, Cohen, R.E, Shi, Y. 登録日 2002-12-02 公開日 2003-01-07 最終更新日 2018-04-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde Cell(Cambridge,Mass.), 111, 2002
8P0D	Human 14-3-3 sigma in complex with human MDM2 peptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Roversi, P, Ward, J, Doveston, R, Kwon, H, Romartinez Alonso, B. 登録日 2023-05-10 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Characterizing the protein-protein interaction between MDM2 and 14-3-3 sigma ; proof of concept for small molecule stabilization. J.Biol.Chem., 300, 2024

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