7RQZ
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![BU of 7rqz by Molmil](/molmil-images/mine/7rqz) | Cryo-EM structure of the full-length TRPV1 with RTx at 48 degrees Celsius, in an open state, class alpha | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7RQY
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![BU of 7rqy by Molmil](/molmil-images/mine/7rqy) | Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an open state, class B | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7RQX
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![BU of 7rqx by Molmil](/molmil-images/mine/7rqx) | Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an intermediate-open state, class A | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7RQU
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![BU of 7rqu by Molmil](/molmil-images/mine/7rqu) | Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in a closed state, class I | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, SODIUM ION, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7RQW
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![BU of 7rqw by Molmil](/molmil-images/mine/7rqw) | Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an open state, class III | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7RQV
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![BU of 7rqv by Molmil](/molmil-images/mine/7rqv) | Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an intermediate-closed state, class II | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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2PNN
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6V9Y
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![BU of 6v9y by Molmil](/molmil-images/mine/6v9y) | Structure of TRPA1 bound with A-967079, PMAL-C8 | 分子名称: | Transient receptor potential cation channel subfamily A member 1 | 著者 | Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D. | 登録日 | 2019-12-16 | 公開日 | 2020-05-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature, 585, 2020
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6V9X
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![BU of 6v9x by Molmil](/molmil-images/mine/6v9x) | Structure of TRPA1 modified by iodoacetamide, PMAL-C8 | 分子名称: | Transient receptor potential cation channel subfamily A member 1 | 著者 | Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D. | 登録日 | 2019-12-16 | 公開日 | 2020-05-06 | 最終更新日 | 2020-09-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature, 585, 2020
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7T6M
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![BU of 7t6m by Molmil](/molmil-images/mine/7t6m) | Cryo-EM structure of TRPV5 in nanodiscs with PI(4,5)P2 at pH6 state 1 | 分子名称: | Transient receptor potential cation channel subfamily V member 5, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Fluck, E.C, Yazici, A.T, Rohacs, T, Moiseenkova-Bell, V.Y. | 登録日 | 2021-12-14 | 公開日 | 2022-05-04 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis of TRPV5 regulation by physiological and pathophysiological modulators. Cell Rep, 39, 2022
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7T6J
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7T6K
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![BU of 7t6k by Molmil](/molmil-images/mine/7t6k) | |
7T6R
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![BU of 7t6r by Molmil](/molmil-images/mine/7t6r) | |
7T6Q
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![BU of 7t6q by Molmil](/molmil-images/mine/7t6q) | Cryo-EM structure of TRPV5 T709D with PI(4,5)P2 in nanodiscs | 分子名称: | Transient receptor potential cation channel subfamily V member 5, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | 著者 | Fluck, E.C, Yazici, A.T, Rohacs, T, Moiseenkova-Bell, V.Y. | 登録日 | 2021-12-14 | 公開日 | 2022-05-04 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis of TRPV5 regulation by physiological and pathophysiological modulators. Cell Rep, 39, 2022
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7T6P
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![BU of 7t6p by Molmil](/molmil-images/mine/7t6p) | |
7T6L
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![BU of 7t6l by Molmil](/molmil-images/mine/7t6l) | |
7T6O
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![BU of 7t6o by Molmil](/molmil-images/mine/7t6o) | |
7T6N
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![BU of 7t6n by Molmil](/molmil-images/mine/7t6n) | |
6V9V
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![BU of 6v9v by Molmil](/molmil-images/mine/6v9v) | Structure of TRPA1 modified by Bodipy-iodoacetamide with bound calcium, LMNG | 分子名称: | CALCIUM ION, Transient receptor potential cation channel subfamily A member 1, ~{N}-[[2,2-bis(fluoranyl)-10,12-dimethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9,11-tetraen-4-yl]methyl]ethanamide | 著者 | Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D. | 登録日 | 2019-12-16 | 公開日 | 2020-05-06 | 最終更新日 | 2020-09-16 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature, 585, 2020
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6V9W
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![BU of 6v9w by Molmil](/molmil-images/mine/6v9w) | Structure of TRPA1 (ligand-free) with bound calcium, LMNG | 分子名称: | CALCIUM ION, Transient receptor potential cation channel subfamily A member 1 | 著者 | Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D. | 登録日 | 2019-12-16 | 公開日 | 2020-05-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature, 585, 2020
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2NYJ
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8JQR
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![BU of 8jqr by Molmil](/molmil-images/mine/8jqr) | Structure of human TRPV1 in complex with antagonist | 分子名称: | 4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile, CHOLESTEROL, Transient receptor potential cation channel subfamily V member 1,PreScission Site,Green fluorescent protein | 著者 | Fan, J, Lei, X. | 登録日 | 2023-06-14 | 公開日 | 2024-08-14 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | 主引用文献 | Structural basis of TRPV1 inhibition by SAF312 and cholesterol. Nat Commun, 15, 2024
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8X94
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7AOV
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![BU of 7aov by Molmil](/molmil-images/mine/7aov) | Crystal Structure of a TRPM2 Domain | 分子名称: | Transient receptor potential cation channel subfamily M member 2, ZINC ION | 著者 | Sander, S, Tidow, H. | 登録日 | 2020-10-15 | 公開日 | 2022-03-02 | 最終更新日 | 2022-08-17 | 実験手法 | X-RAY DIFFRACTION (2.00001621 Å) | 主引用文献 | The crystal structure of TRPM2 MHR1/2 domain reveals a conserved Zn 2+ -binding domain essential for structural integrity and channel activity. Protein Sci., 31, 2022
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6X2J
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![BU of 6x2j by Molmil](/molmil-images/mine/6x2j) | Structure of human TRPA1 in complex with agonist GNE551 | 分子名称: | 5-amino-1-[(4-bromo-2-fluorophenyl)methyl]-N-(2,5-dimethoxyphenyl)-1H-1,2,3-triazole-4-carboxamide, Transient receptor potential cation channel subfamily A member 1 | 著者 | Rohou, A, Rouge, L, Chen, H. | 登録日 | 2020-05-20 | 公開日 | 2020-11-18 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel. Neuron, 109, 2021
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