8W7H

Purine Nucleoside Phosphorylase in complex with MMV000848

Summary for 8W7H

Entry DOI	10.2210/pdb8w7h/pdb
Descriptor	Purine nucleoside phosphorylase, (2R)-1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	protein binding, transferase-inhibitor complex, transferase/inhibitor
Biological source	Plasmodium falciparum 3D7
Total number of polymer chains	1
Total formula weight	28302.55
Authors	Chung, Z.,Lin, J.Q.,Lescar, J. (deposition date: 2023-08-30, release date: 2024-01-17, Last modification date: 2024-01-31)
Primary citation	Chung, Z.,Lin, J.,Wirjanata, G.,Dziekan, J.M.,El Sahili, A.,Preiser, P.R.,Bozdech, Z.,Lescar, J. Identification and structural validation of purine nucleoside phosphorylase from Plasmodium falciparum as a target of MMV000848. J.Biol.Chem., 300:105586-105586, 2023 Cited by PubMed: 38141766 DOI: 10.1016/j.jbc.2023.105586 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation